ID A0A2D0QHC6_ICTPU Unreviewed; 546 AA.
AC A0A2D0QHC6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Wiskott-Aldrich syndrome protein family member {ECO:0000256|RuleBase:RU367034};
DE Short=WASP family protein member {ECO:0000256|RuleBase:RU367034};
GN Name=wasf1 {ECO:0000313|RefSeq:XP_017317659.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017317659.1};
RN [1] {ECO:0000313|RefSeq:XP_017317659.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017317659.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Downstream effector molecule involved in the transmission of
CC signals from tyrosine kinase receptors and small GTPases to the actin
CC cytoskeleton. Promotes formation of actin filaments. Part of the WAVE
CC complex that regulates lamellipodia formation. The WAVE complex
CC regulates actin filament reorganization via its interaction with the
CC Arp2/3 complex. {ECO:0000256|RuleBase:RU367034}.
CC -!- SUBUNIT: Binds actin and the Arp2/3 complex.
CC {ECO:0000256|RuleBase:RU367034}.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU367034}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the SCAR/WAVE family.
CC {ECO:0000256|ARBA:ARBA00006993, ECO:0000256|RuleBase:RU367034}.
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DR RefSeq; XP_017317659.1; XM_017462170.3.
DR RefSeq; XP_017317664.1; XM_017462175.1.
DR AlphaFoldDB; A0A2D0QHC6; -.
DR STRING; 7998.ENSIPUP00000009995; -.
DR Ensembl; ENSIPUT00000010448; ENSIPUP00000010011; ENSIPUG00000006830.
DR GeneID; 108261263; -.
DR KEGG; ipu:108261263; -.
DR CTD; 8936; -.
DR OrthoDB; 616448at2759; -.
DR Proteomes; UP000221080; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:UniProtKB-UniRule.
DR CDD; cd22071; WH2_WAVE-1; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 6.10.280.150; -; 2.
DR InterPro; IPR028288; SCAR/WAVE_fam.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR12902; WASP-1; 1.
DR PANTHER; PTHR12902:SF8; WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY MEMBER 1; 1.
DR Pfam; PF02205; WH2; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM00246; WH2; 1.
DR PROSITE; PS51082; WH2; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|RuleBase:RU367034};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cytoplasm {ECO:0000256|RuleBase:RU367034};
KW Cytoskeleton {ECO:0000256|RuleBase:RU367034};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
SQ SEQUENCE 546 AA; 60860 MW; 203574157EA8546D CRC64;
MPLVKRSIEP RHLCHTALPC SIKNELECVT NISLANVIRQ LSSLSKYAED LFGELFNEAH
AFSFRVNSLQ ERVDRLSISV TQLDPKEEEL SLQDITMRKA FRSSTIQDQQ LFDRESLPIP
MQETFDLCEQ PPPLNILSPY RDDGKQALKF YTNPSYFFDL WREKMLQDTE DKRKEKRKQK
LQDPRLYDQV YKYLDLPGQL KNIDRPAEPE KVPRAPHDRK KEWQKLALGA ELAEDDTEEK
HKDTSNGLAP YHDPRQMYMD HLDGSFSLAA LPYSQMSELL NRTGERMYGR PHEPPPPPPS
HPADIKPASA ISSSSGFSDS RPQSPARTPV FLNPNAPPPP PPPLPPPPPP LPSTVSGSSM
RSTPPPPIPP LPSQLPLAIP PPPAPLQIAP GVLHPAPPPV APPLHSSPAR LQQDKVLLPG
MGDGTVLPPP PPPPPLPHPG ARSSPPCQPP GPPPVPSFPV SSPPTHSGHE VKRHPSNLPP
ISDARSVLLE AIRKGIQLRK VEEQREQEAK HERVGNDVAT ILSRRIAVEY SDSEDDSEFD
EVDWME
//
