ID A0A2D0QM74_ICTPU Unreviewed; 255 AA.
AC A0A2D0QM74;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Dickkopf-related protein 2 {ECO:0000313|RefSeq:XP_017318816.1};
GN Name=dkk2 {ECO:0000313|RefSeq:XP_017318816.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017318816.1};
RN [1] {ECO:0000313|RefSeq:XP_017318816.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017318816.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the dickkopf family.
CC {ECO:0000256|ARBA:ARBA00010842}.
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DR RefSeq; XP_017318816.1; XM_017463327.3.
DR AlphaFoldDB; A0A2D0QM74; -.
DR STRING; 7998.ENSIPUP00000012185; -.
DR Ensembl; ENSIPUT00000012695; ENSIPUP00000012185; ENSIPUG00000008298.
DR GeneID; 108262966; -.
DR KEGG; ipu:108262966; -.
DR CTD; 27123; -.
DR OMA; XICIPVT; -.
DR OrthoDB; 4329885at2759; -.
DR Proteomes; UP000221080; Chromosome 3.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR CDD; cd23015; Dkk2_Cys1; 1.
DR CDD; cd23273; Dkk2_Cys2; 1.
DR Gene3D; 2.10.80.10; Lipase, subunit A; 1.
DR InterPro; IPR006796; Dickkopf_N.
DR InterPro; IPR048500; DIKK1/2/4_C-subdom1.
DR InterPro; IPR048499; DIKK1/2/4_C-subdom2.
DR InterPro; IPR039863; DKK1-4.
DR InterPro; IPR047303; Dkk2_Cys1.
DR InterPro; IPR047302; Dkk2_Cys2.
DR PANTHER; PTHR12113:SF12; DICKKOPF-RELATED PROTEIN 2; 1.
DR PANTHER; PTHR12113; DICKKOPF3-LIKE 3; 1.
DR Pfam; PF04706; Dickkopf_N; 1.
DR Pfam; PF21481; DIKK1-2-4_C-subdom1; 1.
DR Pfam; PF21479; DIKK1-2-4_C-subdom2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..255
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012248884"
FT DOMAIN 82..133
FT /note="Dickkopf N-terminal cysteine-rich"
FT /evidence="ECO:0000259|Pfam:PF04706"
FT DOMAIN 175..204
FT /note="Dickkopf-related protein 1/2/4 C-terminal subdomain
FT 1"
FT /evidence="ECO:0000259|Pfam:PF21481"
FT DOMAIN 207..254
FT /note="Dickkopf-related protein 1/2/4 C-terminal subdomain
FT 2"
FT /evidence="ECO:0000259|Pfam:PF21479"
FT REGION 50..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 255 AA; 28170 MW; 769AC841CCFDF5EF CRC64;
MLALTRSSCC CCCWLLALLL SHAGVKAANH NKNINSIKTA PLGEAPTATA AAAAASTHPG
SVAHAPAKKS NVPVQEYSGE KQCSNDKDCP VSSYCHSTQH APSRCLTCRR RKKRCHRDAM
CCPGNRCSNF ICVPFPENLM THHISSLKEQ KKLSKDKAWK KSGKVQTKVS LKGHEGDACL
RSSDCSEGYC CARHFWTKIC KPVLRQGEVC TKQRKKGSHN LEIFQRCDCA KGLVCKVWKD
ATSYSRSRLH MCQRT
//
