ID A0A2D0QN80_ICTPU Unreviewed; 928 AA.
AC A0A2D0QN80;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Potassium voltage-gated channel subfamily KQT member 5 isoform X9 {ECO:0000313|RefSeq:XP_017319847.1};
GN Name=kcnq5a {ECO:0000313|RefSeq:XP_017319847.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017319847.1};
RN [1] {ECO:0000313|RefSeq:XP_017319847.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017319847.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_017319847.1; XM_017464358.3.
DR AlphaFoldDB; A0A2D0QN80; -.
DR Ensembl; ENSIPUT00000037595; ENSIPUP00000036178; ENSIPUG00000024247.
DR GeneID; 108263500; -.
DR CTD; 556841; -.
DR OrthoDB; 2911641at2759; -.
DR Proteomes; UP000221080; Chromosome 3.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR PANTHER; PTHR47735:SF8; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 5; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 92..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 92..321
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 412..599
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 903..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..857
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 928 AA; 102791 MW; BC3B1285494013E9 CRC64;
MPRDHGGDES TSGLWMKTSP GRRAENYGLK DVEGGRGGMS SAESARRARG ARLSLLGKPL
AYGAQSGRRN VRYRKLQNYL YNVLERPRAW AFVYHAFVFI LVFGCLVLSV FSTIPDHMDL
SNHCLLILEF VMIVVFGLEY IIRIWSAGCC CRYRGWQGRL RFARKPFCVI DIIVLIASIA
VVSAGSQGNI FAASALRSLR FLQILRMVRM DRRGGTWKLL GSVVYAHSKE LVTAWYIGFL
VLIFSSFLVY LVEKDLNTQF NTYADALWWG TITLTTIGYG DKTPQTWPGR LLSAGFALLG
ISFFALPAGI LGSGFALKVQ EQHRQKHFEK RRNPAASLIQ CVWRSYAADE NSVSIATWKP
HLKALHTCSP TKKDQGESTT SQKLSFKERV RMASPRGQSI KSRQTSLNDR RSPVTEVATE
GSSPAKVQKS WSFNDRTRFR PSLRLKSQSR TMPEADSLGG EECFDEKGCH CDVTVEDLSA
SLRAVIRAVR IMKFHVAKKK FKETLRPYDV KDVIEQYSAG HLDMLCRIKS LQTRVDQILG
KGQIPMDRKM RDRILPEGES LDHDMSMLGR VCKVERQVQS IESKLDSLLD IYRQVLKKGS
SSVLGLSALP LFELEQTSDY HSSIQSKDIS STQLSRSGIS RSVSDNLPCG LQLVLAPSEL
NVGTGFPASS SSFSPSSLLQ NPPSSPDSVY PASPPPILTP NNLSRAHSNF PELTRPLPMT
TPNTHTLQLP TVAPLPPSRP SSMISETLQE SNPNACLLNT QTEPVSDTDA KCSESTVQLR
SRPERSPKEE GSWRRHLSLE INPLSLTSSA AVNPLQVDRA LGKSLSAQNL MLPSGTECHP
NLSARSSGSS NNESNDREML TDWGETELFI TDKELATSKG NFNLLSQQST DTSFTTELVQ
MVGSGPTQSQ TRPSGSSESL SLPHVLLN
//
