ID A0A2D0QP17_ICTPU Unreviewed; 1081 AA.
AC A0A2D0QP17;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Inactive tyrosine-protein kinase 7 {ECO:0000313|RefSeq:XP_017320147.1};
GN Name=ptk7b {ECO:0000313|RefSeq:XP_017320147.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017320147.1};
RN [1] {ECO:0000313|RefSeq:XP_017320147.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017320147.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_017320147.1; XM_017464658.3.
DR AlphaFoldDB; A0A2D0QP17; -.
DR STRING; 7998.ENSIPUP00000028664; -.
DR Ensembl; ENSIPUT00000029834; ENSIPUP00000028664; ENSIPUG00000019376.
DR GeneID; 108263634; -.
DR KEGG; ipu:108263634; -.
DR CTD; 100150035; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000221080; Chromosome 3.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05046; PTK_CCK4; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR PANTHER; PTHR45080; CONTACTIN 5; 1.
DR PANTHER; PTHR45080:SF21; INACTIVE TYROSINE-PROTEIN KINASE 7; 1.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 3.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PIRSF; PIRSF000615; TyrPK_CSF1-R; 7.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00409; IG; 7.
DR SMART; SM00408; IGc2; 7.
DR SUPFAM; SSF48726; Immunoglobulin; 7.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50835; IG_LIKE; 7.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR000615-2};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Kinase {ECO:0000313|RefSeq:XP_017320147.1};
KW Magnesium {ECO:0000256|PIRSR:PIRSR000615-3};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000615-3};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000615-2};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Transferase {ECO:0000313|RefSeq:XP_017320147.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 716..737
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 75..147
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 157..236
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 245..331
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 354..420
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 425..511
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 520..601
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 606..681
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 807..1077
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT ACT_SITE 941
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
FT BINDING 814..821
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-2"
FT BINDING 841
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-2"
FT BINDING 887..893
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-2"
FT BINDING 945
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-2"
FT BINDING 946
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
SQ SEQUENCE 1081 AA; 121062 MW; 53122F9A9E68B81F CRC64;
MDISDTSDTL ARIATQHRGA SRSSTSFRNR RRWTLFPVRM NSLLAIIIFC TNVLCVQSLS
LHFSKEPQSQ DALHGRSAML RCEVSEAAGV RYSWLQDGQP VQGSERRFIE DGSLKFTAVD
RHLDTGNFQC VATSLTSGEV ATSTNASFNI KWLDSGPVTL KEPASVEEID DAEQIVLQCQ
IDGHPRPNSK WYKDGVLLSV KERSITLRNP VPGDSGTYSC CARNGAGQLC SNSNFTLNII
DKTIPRVVVA PEDQVVFRNE EAVFHCQFSA KPPPVIEWLH ESEPVINKPR VLVYDNGTLR
ITQVKPRNTG RYTCVVRYGT DRQLNVEATL HIAEIEDMGG RLFRYFSANN MERISCVPPH
GHPKPVVWWE KDGARVPTKG RVHQQDMDLI FNPAVVGDSG TYVCMAQNKA GQRRQEVTVT
VAGPPEWVNR PQDTEMEEGQ PGYLHCRIQA TPPAQVTWYR NMQEISEEKS QYKLFPNGTL
RINSVEVYDG LVYNCVCKTA SGILNGQAKV YVLEKLKFTP APQSPQCLQL DKEASVQCSA
TGRETPTIHW TKADGSAIPA HVKQINGTLQ FEKVTRSDAG NFTCVASNRP QGEIRAYVSL
TVGVYTEFKV EPEYTTVYQG HTATMHCQAT GDPQPYIQWI VKDKTLSVSN TRFQELPNGS
LIIRDVTTAD TGKYTCIAGN SCGIRHRVAQ LYVVEKPKHD RDSDEGKTPY KMIQTIGLSV
GAAVAYIIAV LGLMFYCKKR RNAKRLQKGQ DGEEPEMECL NGGAMQHNGQ TTAEIQEEVA
LTNLETVSTA EKHHSNTDKF HFPRADLQTI TTLGKGEFGE VLLAKARGIE EGEEQTVVLV
KSLLSRDELS QAEFRRQVDM FSKLNHTNIV RLLGLCKDTE PHYMILEYID LGDLKQFLRI
SRSKDENLKP QPISTKTKVS ICAQVAAGME HLSNQRFVHK DLATRNCLIS GERHVKISAL
GLSKDVYNSE YYHYRQNWIP LRWLPAESVF ENDFSTKSDV WAFGVLMWEV FSHGELPYSS
LSHEDVLEGL QAGTLKLSAP EVCPSKVYKL MSRCWAPSLK ERPSFSELIQ VLGDIPLDSK
V
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