ID A0A2D0QR39_ICTPU Unreviewed; 2043 AA.
AC A0A2D0QR39;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Myoferlin isoform X2 {ECO:0000313|RefSeq:XP_017319940.1};
GN Name=myofl {ECO:0000313|RefSeq:XP_017319940.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017319940.1};
RN [1] {ECO:0000313|RefSeq:XP_017319940.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017319940.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004483}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004483}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the ferlin family.
CC {ECO:0000256|ARBA:ARBA00007561}.
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DR RefSeq; XP_017319940.1; XM_017464451.3.
DR Ensembl; ENSIPUT00000038028; ENSIPUP00000036597; ENSIPUG00000024482.
DR GeneID; 108263542; -.
DR CTD; 559066; -.
DR OrthoDB; 991411at2759; -.
DR Proteomes; UP000221080; Chromosome 3.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08373; C2A_Ferlin; 1.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 7.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037726; C2A_Ferlin.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012560; Ferlin_A-domain.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF33; SPERM VESICLE FUSION PROTEIN FER-1; 1.
DR Pfam; PF00168; C2; 7.
DR Pfam; PF08165; FerA; 1.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 7.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM01200; FerA; 1.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 7.
DR PROSITE; PS50004; C2; 7.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2010..2031
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..101
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 188..305
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 344..480
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1114..1242
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1274..1404
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1522..1640
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1756..1906
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 129..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1962..1982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1962..1977
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2043 AA; 230715 MW; FED2468EC0E482AC CRC64;
MLKVVVECAK AIPKKTLGNP DPITAVLFKG EKKKTKAIPS ELNPVWNEIL EFDLKGSPLD
SSSFIDVVVK DYETIGKDKF IGSAKISLRD LAGGQTKSLP SRNVPLANEK KQDIGATISL
VITYEPPASA IPNPNAQVDG DASAGETGVS SAGNEGGDEE TTDWGGPRAP GETSAPGQPG
KTPQKMIRTG QKRQKALSNK PQDFQIRIRV IEGRQLPGNN IKPVVKVSVC GQTHRTRIRR
GNNPFFDEIF FYNMNMLPSE LLDENIYIRV YNSSSLRSDS LLGEFKLDVG FIYDEPAHAI
MKKWLLLSDP DDSSAGARGY LKVNMIIVGT GDEPPAEKKE YNEEQDDIES NLLLPAGVTM
RSAILSLKVY RAEDMPQMDD AFAQTVKSIF GGEGDKKNLV DPFLEVSFAG KKLCTKIIEK
NANPEWNQLI QLMVKFPSMC ERIKLTMFDW DRFTSNDTVG TTYLNLSKIS SSGGEIEAGS
LNENGLPGSD VDRNGTEVGF LPAFGPCYLN LYGSTREFSD LPDPYVELNL GQGEGVAYRG
RVLIELSTRL DDKIDKKVDD LNNDDVLVAQ KYQRKRKFSL CAVLHSACML QEPGEPIQFE
ISIGNYGNKM DSTCKPLAST TQYSCAVFDG NHYYYLPWAD TKPVVILNSF WEDISHRLDS
VNIILFIADR LQANITTLKT AILAKVTETR LAEIWLKLIT QLIEDLTNYR LPDMEAKPNV
TALDVQIKKL RDKTVINIRD AACHMRDEAT DVKATLTDIE DWLDRLQQIT EEPQNSMPDI
IIWMLRGEKR LAYARIPANE VLFSTHSEEA TGKYCGKTQT IFMKYPMDKN KGVKIPVQLR
LNMWLGLSAH EKKFNSFAEG TFSVYAEMYE NQAQVFGKWG TTGLVGRHRF SDVTGKVKLK
QEYFLPPRGW EWEGDWYVDP ENCLLTEADA GHTEFTDEVY ENESRYPGGE WKPATENYTD
VNGEKAQKPS EIECPPGWKV IQDWSFDSNR AVDEKGWEYG ITIPPGDKPS SWVAAEKMYH
VHRRKRLIRL RKKIANAPAS EKKEAGDGWE YSSLIGWKFH RKERSSDTFR RRRWRRKMAP
SDRVGASAIF QLEGAMGGEV DEKDSKKEAA KLFGANTPTV SCNFSRSYMY HLRVYVYQAR
NLLPMDKDSF SDPYCHVSFL HVSKTTEIIK ANLNPTFDQT LIFNDIEIYG DPQTVAQNPP
SIVLELFDSD QVGKDEAMGR CTCPPVVKLN PSTPLSPKLL WFPITMKGRS AGQMLVAAEL
LLKDRAAETE LPLVPPRRGE NLYMVPQGIR PVVQLTAIEI LAWGLRNMKA YQLAAVSSPS
LIVECGGQIV QTTVIKNIKK NPNFPGSVLF LKVLLPKEEM YTPPIVLKVI DHRPFGRKPI
VGQCTIDSLE EYRCDPNMGT SEVSRTARVS MMVATSRDVI INIEDKIPIV HSQVDEAVDW
WSKFYASIGE HEKYGPYLQK GYSTLTVYET ELESVFHGLT DFCNTFKLYR GKSDDGEEDP
SVVGEFKGSF RIYPLSDDPG VQAPPRQFRE LPESGPQECL VRIYVLRCID LQPKDNNGLC
DPYLKITLGK KTIEDRDNYK PNTLNPEFGR VFELSCFLPQ DKDLKISVYD FDLLSRDEKV
GDTVIDLENR LLSRFSAHCG LSQSYCVSGV NQWRDQLKPS QILDNLAKLR GVPPPQIAED
GSSLSFEGRD YNLQDLEASK VLHQHLGPAK ERICLHVLRK QGLVPEHVET RTLYSSFQPT
LSQGKVQMWV DIFPKSLGSP GPPVDISPRK AKKYYLRAVI WNTTDVILDE TSITGEKMSD
IYVKGWMPGM EQDKQKTDVH YRSLDGDGNF NWRFVFGFDY LPAEQLCLVS KKEHFWSLDK
TEFRIPPKLT IQIWDNDKFS LDDYLGTVEL DLNNLIPPTK TSEKCSLDML IQGTNRSIPS
KSLFAQKCVR GWWPCAMEED GKKVLTGKVE MTLEIVDEKE VDERPAGKGR DEPNMNPKLD
PPNRPDTSFL WFTNPCKSLK FIVWRRFKCL FILIIILILV GLFVGILLYS LPNYISMKIV
KPF
//
