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Database: UniProt
Entry: A0A2D0QUC8_ICTPU
LinkDB: A0A2D0QUC8_ICTPU
Original site: A0A2D0QUC8_ICTPU 
ID   A0A2D0QUC8_ICTPU        Unreviewed;      5083 AA.
AC   A0A2D0QUC8;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   16-JAN-2019, entry version 4.
DE   SubName: Full=ryanodine receptor 1-like isoform X6 {ECO:0000313|RefSeq:XP_017322033.1};
GN   Name=LOC108264731 {ECO:0000313|RefSeq:XP_017322033.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|Proteomes:UP000221080, ECO:0000313|RefSeq:XP_017322033.1};
RN   [1] {ECO:0000313|RefSeq:XP_017322033.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017322033.1};
RG   RefSeq;
RL   Submitted (NOV-2017) to UniProtKB.
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DR   RefSeq; XP_017322033.1; XM_017466544.1.
DR   UniGene; Ipu.41538; -.
DR   GeneID; 108264731; -.
DR   OrthoDB; 5161at2759; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000221080};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_017322033.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221080};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4371   4391       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4604   4624       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4686   4708       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4822   4842       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4882   4904       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4963   4986       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      103    158       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      165    210       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    273       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      279    334       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      344    401       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      593    803       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1019   1215       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1349   1561       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      466    486       {ECO:0000256|SAM:Coils}.
FT   COILED     1905   1925       {ECO:0000256|SAM:Coils}.
FT   COILED     1936   1956       {ECO:0000256|SAM:Coils}.
FT   COILED     3697   3724       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5083 AA;  576257 MW;  E88A9714A358D816 CRC64;
     MAEGEGGDEE IQFLRTDDTV VLQCTATILK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICAFILE QSLSVRALQE MLANTMEMEA VDLDQWSSQG GGHRTLLYGH AILLRHSHSG
     MYLSCLTTSR SLTDKLAFDV GLQEDSTGEA CWWTIHPASK QRSEGEKVRV GDDLILVSVS
     SERYLHLSYA SGDLMVDASF MQTLWNMNPV CSGCELAEGY LTGGHVLRLF HGHMDECLAI
     PPPDQGEDQR KIAQYESGAV CSQARSLWRL EPLRISWSGG HMKWGQPFRI RHITTGRYIC
     LNEEKGLMVL DPEKANTKQS AFCFRASKEK VEVVKKRDVE GMGIAEIKYG ESMCFVQHVS
     TGLWLTYAAL DAKAARLGTL KRKVTLHQEG HMDDALVMSR SQTEESQAAR MIYSTTGLFK
     QFIKGLDSLS GKNRAAGPVS LPLDGVVLSL QDLIHYFQPP EEELEHEEKQ TKLRSLRNRQ
     NLFQEEGMIT IVLECVDRLN VYNTAAHFSE FAGEEAAESW KEIVNLLYEL LASLIRGNRA
     NCALFCDNLD WLVSKLDRLE ASSGILEVLY CILIESPEVL NIIQENHIKS IISLLDKHGR
     NHKVLDVLRS LCVCNGVAVR SNQNLITENL LPRRELLLQT NIVNYVSSVR PNIFLGTCEG
     STQYKKWYYE MIVDYVEPFV SAQATHLRVG WALTEGYSPY PGGGEGWGSN GVGDDLYSYG
     FDGLHLWSGH VARQVASPNQ HILAADDVVS CCLDLSVPSI SFRINGHPVQ GMFENFNLDG
     LFFPVISFSA GVKARFLLGG RHGDFKFFPP PGYAPCYEAL LPRERMRIEP IKEYKHDFSG
     VRNLLGPTQS LTHTSFTPCP VDTAQIVLPP HLERIREKLA ENIHELWAVT RIEQGWTYGL
     FRDDNKKLHP CLVDFQSLPE PERNYNLQMS GETLKTLLAL GCHVGMGDEK AEENLKKIKL
     PKTYVMSSGY KPAPLDLSHV KLTPNQNQLV EKLAENGHNV WARDRVRQGW TYSIVQDILN
     KRNPRLVPYV LLDERTKKTN RDSVNNAVRT LIGYGYNIEP PDQESSGHSL DSRRGDKVRI
     FRAEKQYAVT SGKWYFEFEA VTTGEMRVGW ARPNVRAGTE LGADELAYVF NGNRAQRWHI
     GNEPFGRQWL SGDVVGCMID LVEMNIMFTL NGEMLISDSG SEMAFKDIEI GDGFIPVCAL
     GLSQMGRINL GQNVSSLRYF AICGLQEGFE PFAINMKRDI TMWFSKSLPQ FIPVPTNHNH
     IELSRVDGTV DCAPCLKLTH KTFGSQNANT DMLFLRLSIP IEFHETFKVQ AGTTPLTRTL
     TIPEDEVLEV DPDSDYEVLK KSACKKEQEE KEKEPSVPRD IPGVKENDKD TASEKGKKKG
     FLFKAKKAAM ITPPPPPPVL PRLFEDVVPD ERDDPEIILN TTTYYYSVRI FAGQEPGGVW
     VGWVTPDYHQ YDLSFDLFKV RTVTVTVGDD KGNIHDSIKR SNCYMVWGGD LISGSQQRFS
     QEDLVVGCLV DLATGLMTFM ANGKEINTFY QVEPNTKLFP AVFVQPFSQN MLQFELGKLK
     NIMPLSAAMF RSERMNPVPQ CPPRLDVEML TPVIWSRVPN HFLKPEVGKV SERHGWMVEC
     TEPLTLMALH IPEENRCIDI LELSEHQDLL KFHHHTLMLY CAVCALGNNR VAHALCSHVD
     ESQLFYAIEN TYLPGPLRIG YYDLLISIHL ESAKRNRLGT NREFIVPMTK ETLSITLYPD
     AEKAHDLPGV GLTTCLRPKL HFSAINFVGT DPDLYTLSPT FPLQELKTKS LCMLTEAVMD
     GSQAMRDPVG GSVEFHFVPI LKLISTLLIM GIFNDDDVKH ILKMIDPSVF SSAEEKASEE
     EGEGEAEKAV SKEQGEETKE KEEAAEGEAE LLDEGVGEEE EDEELKALKK EEGEEGEELE
     KAEEEQQAGQ KVGGEKAEEE KEAEEGEEGH EEEEEVPEEG LLQMKLPESV KLQMCTLLQY
     FCDCELRHRV EAIVAFSDTF VQQIQTNQRY RYNQLMRAFT MSAAETARRT REFRSPPQEQ
     VIMLTNFKHS PEDDECPVPE EVREPLQNFH SDILNHCGIH LEEEEEEEEV DMSLKGRLLK
     LVERVKKLRK QPEEEEKEPE PNEEPKPSTL QELISHTMIH WAQESFIQNP ELVRMMFSLL
     HRQYDSLGEL IRAVPKAYAI NAVSVQDTMD LLECLGQIRS LLIVQMGPEE ERLMIQSIGN
     IMNNKLFYQH PNLMRALGMH ETVMEVMVNV LGGGGDSKEI RFPQMVTNCC RFLCYFCRIS
     RQNQRSMFDH LSYLLQNSGI GLGMRGSTPL DVAAASCIDN NELALALQEQ DLEMVVTYLA
     GCGLQMCPML LSKGYPDIGW NPGGGERYLD FLRFAVFVNG ESVEENANVV VRLLIRRPEC
     FGPALRGEGG AGLLAAMEEA IKISEDPARD GPTPKKDRRF MFGAEEQQEE NRLHLGNAIM
     SFYSALIDLL GRCAPEMHLI QAGKGEALRI RAILRSLVPI EDLVGVISLP VQIPTYGKDE
     QIVEPKMSAS FVPDHKASMV LFLDRVYGID NQDFLLHVLE VGFLPDMRAA ASLDTVAFST
     TEMALALNRY LCSAVLPLLT KCAPLFAGTD HRAIMIDSML HTIYRLSRGR ALTKAQRDVI
     EDCLMSLVKY LHPSMLQHLL RRLVFDVPIL NEYAKMPLKL LTNHYERCWK YYCLPNGWAN
     FGTTSEEELH LSRKLFWGIF ESLAHKKFDA ELFKIAMPCI CAIAGAIPPD YVDASYSATE
     KKATVDAEGN FDPRPVETTN TIIPEKLDAF INKFAENTHD RWAFEKIQNN WTYGETLDEI
     GKTHPMLRPY KTFSEKDKEI YRWPIKESIK AMLAWEWTLE KARDEGEKVE KAATRKISQT
     AQATYDPSQG YSPQPVDLTT MALSRELQSM AEQLAENYHN TWGRKKKMEL QAKGGGTHPL
     LVPYDTLTAK EKARDREKAQ DLLKFLQFEG YAVTRGLKDM EQEISSIEKR FAYGFLQKLL
     KWMEIAQEFI AHLEAVVSSG RVEKSPHEQE IKFFAKILLP LVNQYFKNHC LYFLSTPAKV
     LGSGGHASNK EKEMIASIFC KLAALVRHRV SLFGTDASAV VNCLHILSHS LDARTVMKSG
     PEIVKAGLRS FFESAADDIE KMVENLKLGK VSTKNQVKGV SQNINYTTIA LLPVLTSLFD
     HIAQHQFGDD VILDDLQISC YRLMCSIYSV GTVKTPHAEK LRPALGECLA HLAAAMPVAY
     LEPHLNEFNA YSVYTTKTPR ERAILGLPSQ VQELCLDIPE LEVLMKEISD LAESGARYTE
     LPHVIEITLP MLCNYLPRWW ERGPENFPEQ EGQLCTEVTS EHLNQLLGSI MKIVVNNLGI
     DEASWMKRLA VFAQPIVSRA KPEMLKSHFI PTMEKLKKRS GKVVAEEDQL RMEGKTEVDS
     EEGTIRDEFA VLCRDLYALY PLLIRYVDNN RARWLTCPDP DAEDLFRMVG EVFIFWSKSH
     NFKREEQNFV VMNEINNMSF LTADSKSKMS KAGDGEGGGA DAERTKKKRR GDRYSVQTSL
     IVAALKKLLP IGLNMCSPAD QELINLAKIR YSLKDTDEEV REFLQNNLYL QGKVEDPSMR
     WQMALYKETS GKAEDAENPE KVVKRVQEVS AVLYHIEVTE HPYKSKKMVW HKLLSKQRRR
     AVVACFRMTP LYNIPRHRGS NMFLDGYRRN WLENEGYSFE DKMINDLSKT LEEEEEEEEE
     TEAKPDPLHQ LILHFSRTAL TEKTKLDVDH LYMAYADIMA KSCHMGEEDR GGEEEEEEEE
     GGEEPSFEVR QNEMEKEMEK QRLLYQQSRL HDRGAAEMVL QMISACKGEP GAMVSSTLKL
     GISILNGGNC DVQQRMLDYL KDKKDVGFFL SLQTLMQTCS VLDLNAFERQ NKAEGLGMVS
     EEGTNMKLER DEKVMADDEF TCDLFRFLQL LCEGHNNDFQ NYLRTQTGST TTINIIICTV
     DYLLRLQESI SDFYWYYSGK DIIDAPGKRN FSKAMTVAKQ VFNSLTEYIQ GPCTGNQQSL
     AHSRLWDAVV GFLHVFAHMM MKLAQSKDSS QIGLLKELLD LQKDMVVMLL SLLEGNVVNG
     TIARQMVDML VESSSNVEMI LKFFDMFLKL KDIVASDAFR DYVTDPRGLI SKKDFSKAMD
     SQKQYSPSEI QFLLSCSEAD ENEMINFEEF ADRFQEPAKD IGFNIAVLLT NLSEHVPHDT
     RLQNFLEQAE SILNYFRPFL GRIEIMGASR RIERIYFEIS EANRNQWEMP QVRESKRQFI
     FDVVNEGGES EKMELFVNFC EDTIFEMNIA SQISEQEEEG IGDKDDEEEE ESGGGSNGEE
     GEEGNGDEAP AESSSAFADF IKSMVNFFNM FTFRNLRRRY RRLRKMTIKE MIVCLVTFFY
     TVIIGILHFI YSVCKGFFLL IWKTLFGGGL VEGAKKITLT EILTNMPDPT QDEVHGDQAS
     EPGARNVQEA GGSGDGEEAG GGEVEDEDGQ EAEGGGRPGI DAPGGLGDMG ETEPEEPPTP
     EGTPLLMRKL RTEGAEGEVV AAEEPAKEEP TPEPEKADAE NGEKTKKEPE PIPEEKVAEE
     EEEETKVKAK AKKEKHSAGD SFELWNELEV QRIKFMNYLS RNFYNLRFLA LFIAFALNFI
     LLFYKVSSSP PGEEFEGSGM FEGSGIPEGS GGEPEGSGME ENGEEDDEEG PLYYFLEEST
     GYMEPAMAFF GILHTVISFL CIIGYNCLKV PLVIFKREKE LARKMEFDGL YVTEQPEDDD
     IKGQWDRLVL NTPTFPNNYW DKFVKRKVLE KYGDIYGRER IAELLGMDLA SLDVSAMTHE
     KKPEPDNSMF TWLTSIDIKY QIWKFGVVFT DNTFLYLVWY MVMSLLGHYN NFFFACHLLD
     IAMGVKTLRT ILSSVTHNGK QLVMTVGLLA VVVYLYTVVA FNFFRKFYNK SEDEDEPDMK
     CDDMMTCYLF HMYVGVRAGG GIGDEIEDPA GDEYELYRVV FDITFFFFVI VILLAIIQGL
     IIDAFGELRD QQEQVREDME TKCFICGIGS DYFDTTPHGF ETHTMEEHNL ANYMFFLMYL
     INKDETEHTG QESYVWKMYQ ERCWDFFPAG DCFRKQYEDQ LAG
//
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