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Database: UniProt
Entry: A0A2D0QUD5_ICTPU
LinkDB: A0A2D0QUD5_ICTPU
Original site: A0A2D0QUD5_ICTPU 
ID   A0A2D0QUD5_ICTPU        Unreviewed;      5086 AA.
AC   A0A2D0QUD5;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   16-JAN-2019, entry version 4.
DE   SubName: Full=ryanodine receptor 1-like isoform X5 {ECO:0000313|RefSeq:XP_017322032.1};
GN   Name=LOC108264731 {ECO:0000313|RefSeq:XP_017322032.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|Proteomes:UP000221080, ECO:0000313|RefSeq:XP_017322032.1};
RN   [1] {ECO:0000313|RefSeq:XP_017322032.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017322032.1};
RG   RefSeq;
RL   Submitted (NOV-2017) to UniProtKB.
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DR   RefSeq; XP_017322032.1; XM_017466543.1.
DR   UniGene; Ipu.41538; -.
DR   GeneID; 108264731; -.
DR   OrthoDB; 5161at2759; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000221080};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_017322032.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221080};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4374   4394       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4607   4627       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4689   4711       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4825   4845       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4885   4907       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4966   4989       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       96    151       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      158    203       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      211    266       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      272    327       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      337    394       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      586    796       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1012   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1342   1554       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      459    479       {ECO:0000256|SAM:Coils}.
FT   COILED     1898   1918       {ECO:0000256|SAM:Coils}.
FT   COILED     1929   1949       {ECO:0000256|SAM:Coils}.
FT   COILED     3690   3717       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5086 AA;  576504 MW;  88225925DF217869 CRC64;
     MAEGEGGDEE IQFLRTDDTV VLQCTATILK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICAFILE QSLSVRALQE MLANTMEMES SQGGGHRTLL YGHAILLRHS HSGMYLSCLT
     TSRSLTDKLA FDVGLQEDST GEACWWTIHP ASKQRSEGEK VRVGDDLILV SVSSERYLHL
     SYASGDLMVD ASFMQTLWNM NPVCSGCELA EGYLTGGHVL RLFHGHMDEC LAIPPPDQGE
     DQRKIAQYES GAVCSQARSL WRLEPLRISW SGGHMKWGQP FRIRHITTGR YICLNEEKGL
     MVLDPEKANT KQSAFCFRAS KEKVEVVKKR DVEGMGIAEI KYGESMCFVQ HVSTGLWLTY
     AALDAKAARL GTLKRKVTLH QEGHMDDALV MSRSQTEESQ AARMIYSTTG LFKQFIKGLD
     SLSGKNRAAG PVSLPLDGVV LSLQDLIHYF QPPEEELEHE EKQTKLRSLR NRQNLFQEEG
     MITIVLECVD RLNVYNTAAH FSEFAGEEAA ESWKEIVNLL YELLASLIRG NRANCALFCD
     NLDWLVSKLD RLEASSGILE VLYCILIESP EVLNIIQENH IKSIISLLDK HGRNHKVLDV
     LRSLCVCNGV AVRSNQNLIT ENLLPRRELL LQTNIVNYVS SVRPNIFLGT CEGSTQYKKW
     YYEMIVDYVE PFVSAQATHL RVGWALTEGY SPYPGGGEGW GSNGVGDDLY SYGFDGLHLW
     SGHVARQVAS PNQHILAADD VVSCCLDLSV PSISFRINGH PVQGMFENFN LDGLFFPVIS
     FSAGVKARFL LGGRHGDFKF FPPPGYAPCY EALLPRERMR IEPIKEYKHD FSGVRNLLGP
     TQSLTHTSFT PCPVDTAQIV LPPHLERIRE KLAENIHELW AVTRIEQGWT YGLFRDDNKK
     LHPCLVDFQS LPEPERNYNL QMSGETLKTL LALGCHVGMG DEKAEENLKK IKLPKTYVMS
     SGYKPAPLDL SHVKLTPNQN QLVEKLAENG HNVWARDRVR QGWTYSIVQD ILNKRNPRLV
     PYVLLDERTK KTNRDSVNNA VRTLIGYGYN IEPPDQESSG HSLDSRRGDK VRIFRAEKQY
     AVTSGKWYFE FEAVTTGEMR VGWARPNVRA GTELGADELA YVFNGNRAQR WHIGNEPFGR
     QWLSGDVVGC MIDLVEMNIM FTLNGEMLIS DSGSEMAFKD IEIGDGFIPV CALGLSQMGR
     INLGQNVSSL RYFAICGLQE GFEPFAINMK RDITMWFSKS LPQFIPVPTN HNHIELSRVD
     GTVDCAPCLK LTHKTFGSQN ANTDMLFLRL SIPIEFHETF KVQAGTTPLT RTLTIPEDEV
     LEVDPDSDYE VLKKSACKKE QEEKEKEPSV PRDIPGVKEN DKDTASEKGK KKGFLFKAKK
     AAMITPPPPP PVLPRLFEDV VPDERDDPEI ILNTTTYYYS VRIFAGQEPG GVWVGWVTPD
     YHQYDLSFDL FKVRTVTVTV GDDKGNIHDS IKRSNCYMVW GGDLISGSQQ RFSQEDLVVG
     CLVDLATGLM TFMANGKEIN TFYQVEPNTK LFPAVFVQPF SQNMLQFELG KLKNIMPLSA
     AMFRSERMNP VPQCPPRLDV EMLTPVIWSR VPNHFLKPEV GKVSERHGWM VECTEPLTLM
     ALHIPEENRC IDILELSEHQ DLLKFHHHTL MLYCAVCALG NNRVAHALCS HVDESQLFYA
     IENTYLPGPL RIGYYDLLIS IHLESAKRNR LGTNREFIVP MTKETLSITL YPDAEKAHDL
     PGVGLTTCLR PKLHFSAINF VGTDPDLYTL SPTFPLQELK TKSLCMLTEA VMDGSQAMRD
     PVGGSVEFHF VPILKLISTL LIMGIFNDDD VKHILKMIDP SVFSSAEEKA SEEEGEGEAE
     KAVSKEQGEE TKEKEEAAEG EAELLDEGVG EEEEDEELKA LKKEEGEEGE ELEKAEEEQQ
     AGQKVGGEKA EEEKEAEEGE EGHEEEEEVP EEGLLQMKLP ESVKLQMCTL LQYFCDCELR
     HRVEAIVAFS DTFVQQIQTN QRYRYNQLMR AFTMSAAETA RRTREFRSPP QEQVIMLTNF
     KHSPEDDECP VPEEVREPLQ NFHSDILNHC GIHLEEEEEE EEVDMSLKGR LLKLVERVKK
     LRKQPEEEEK EPEPNEEPKP STLQELISHT MIHWAQESFI QNPELVRMMF SLLHRQYDSL
     GELIRAVPKA YAINAVSVQD TMDLLECLGQ IRSLLIVQMG PEEERLMIQS IGNIMNNKLF
     YQHPNLMRAL GMHETVMEVM VNVLGGGGDS KEIRFPQMVT NCCRFLCYFC RISRQNQRSM
     FDHLSYLLQN SGIGLGMRGS TPLDVAAASC IDNNELALAL QEQDLEMVVT YLAGCGLQMC
     PMLLSKGYPD IGWNPGGGER YLDFLRFAVF VNGESVEENA NVVVRLLIRR PECFGPALRG
     EGGAGLLAAM EEAIKISEDP ARDGPTPKKD RRFMFGAEEQ QEENRLHLGN AIMSFYSALI
     DLLGRCAPEM HLIQAGKGEA LRIRAILRSL VPIEDLVGVI SLPVQIPTYG KDEQIVEPKM
     SASFVPDHKA SMVLFLDRVY GIDNQDFLLH VLEVGFLPDM RAAASLDTVA FSTTEMALAL
     NRYLCSAVLP LLTKCAPLFA GTDHRAIMID SMLHTIYRLS RGRALTKAQR DVIEDCLMSL
     VKYLHPSMLQ HLLRRLVFDV PILNEYAKMP LKLLTNHYER CWKYYCLPNG WANFGTTSEE
     ELHLSRKLFW GIFESLAHKK FDAELFKIAM PCICAIAGAI PPDYVDASYS ATEKKATVDA
     EGNFDPRPVE TTNTIIPEKL DAFINKFAEN THDRWAFEKI QNNWTYGETL DEIGKTHPML
     RPYKTFSEKD KEIYRWPIKE SIKAMLAWEW TLEKARDEGE KVEKAATRKI SQTAQATYDP
     SQGYSPQPVD LTTMALSREL QSMAEQLAEN YHNTWGRKKK MELQAKGGGT HPLLVPYDTL
     TAKEKARDRE KAQDLLKFLQ FEGYAVTRGL KDMEQEISSI EKRFAYGFLQ KLLKWMEIAQ
     EFIAHLEAVV SSGRVEKSPH EQEIKFFAKI LLPLVNQYFK NHCLYFLSTP AKVLGSGGHA
     SNKEKEMIAS IFCKLAALVR HRVSLFGTDA SAVVNCLHIL SHSLDARTVM KSGPEIVKAG
     LRSFFESAAD DIEKMVENLK LGKVSTKNQV KGVSQNINYT TIALLPVLTS LFDHIAQHQF
     GDDVILDDLQ ISCYRLMCSI YSVGTVKTPH AEKLRPALGE CLAHLAAAMP VAYLEPHLNE
     FNAYSVYTTK TPRERAILGL PSQVQELCLD IPELEVLMKE ISDLAESGAR YTELPHVIEI
     TLPMLCNYLP RWWERGPENF PEQEGQLCTE VTSEHLNQLL GSIMKIVVNN LGIDEASWMK
     RLAVFAQPIV SRAKPEMLKS HFIPTMEKLK KRSGKVVAEE DQLRMEGKTE VDSEEGTIRD
     EFAVLCRDLY ALYPLLIRYV DNNRARWLTC PDPDAEDLFR MVGEVFIFWS KSHNFKREEQ
     NFVVMNEINN MSFLTADSKS KMSKAGDGEG GGADAERTKK KRRGDRYSVQ TSLIVAALKK
     LLPIGLNMCS PADQELINLA KIRYSLKDTD EEVREFLQNN LYLQGKVEDP SMRWQMALYK
     ETSGKAEDAE NPEKVVKRVQ EVSAVLYHIE VTEHPYKSKK MVWHKLLSKQ RRRAVVACFR
     MTPLYNIPRH RGSNMFLDGY RRNWLENEGY SFEDKMINDL SKTLEEEEEE EEETEAKPDP
     LHQLILHFSR TALTEKTKLD VDHLYMAYAD IMAKSCHMGE EDRGGEEEEE EEEGGEEPSF
     EVRQNEMEKE MEKQRLLYQQ SRLHDRGAAE MVLQMISACK GEPGAMVSST LKLGISILNG
     GNCDVQQRML DYLKDKKDVG FFLSLQTLMQ TCSVLDLNAF ERQNKAEGLG MVSEEGTNMK
     LERDEKVMAD DEFTCDLFRF LQLLCEGHNN DFQNYLRTQT GSTTTINIII CTVDYLLRLQ
     ESISDFYWYY SGKDIIDAPG KRNFSKAMTV AKQVFNSLTE YIQGPCTGNQ QSLAHSRLWD
     AVVGFLHVFA HMMMKLAQSK MHPDPGLRNG DSSQIGLLKE LLDLQKDMVV MLLSLLEGNV
     VNGTIARQMV DMLVESSSNV EMILKFFDMF LKLKDIVASD AFRDYVTDPR GLISKKDFSK
     AMDSQKQYSP SEIQFLLSCS EADENEMINF EEFADRFQEP AKDIGFNIAV LLTNLSEHVP
     HDTRLQNFLE QAESILNYFR PFLGRIEIMG ASRRIERIYF EISEANRNQW EMPQVRESKR
     QFIFDVVNEG GESEKMELFV NFCEDTIFEM NIASQISEQE EEGIGDKDDE EEEESGGGSN
     GEEGEEGNGD EAPAESSSAF ADFIKSMVNF FNMFTFRNLR RRYRRLRKMT IKEMIVCLVT
     FFYTVIIGIL HFIYSVCKGF FLLIWKTLFG GGLVEGAKKI TLTEILTNMP DPTQDEVHGD
     QASEPGARNV QEAGGSGDGE EAGGGEVEDE DGQEAEGGGR PGIDAPGGLG DMGETEPEEP
     PTPEGTPLLM RKLRTEGAEG EVVAAEEPAK EEPTPEPEKA DAENGEKTKK EPEPIPEEKV
     AEEEEEETKV KAKAKKEKHS AGDSFELWNE LEVQRIKFMN YLSRNFYNLR FLALFIAFAL
     NFILLFYKVS SSPPGEEFEG SGMFEGSGIP EGSGGEPEGS GMEENGEEDD EEGPLYYFLE
     ESTGYMEPAM AFFGILHTVI SFLCIIGYNC LKVPLVIFKR EKELARKMEF DGLYVTEQPE
     DDDIKGQWDR LVLNTPTFPN NYWDKFVKRK VLEKYGDIYG RERIAELLGM DLASLDVSAM
     THEKKPEPDN SMFTWLTSID IKYQIWKFGV VFTDNTFLYL VWYMVMSLLG HYNNFFFACH
     LLDIAMGVKT LRTILSSVTH NGKQLVMTVG LLAVVVYLYT VVAFNFFRKF YNKSEDEDEP
     DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE DPAGDEYELY RVVFDITFFF FVIVILLAII
     QGLIIDAFGE LRDQQEQVRE DMETKCFICG IGSDYFDTTP HGFETHTMEE HNLANYMFFL
     MYLINKDETE HTGQESYVWK MYQERCWDFF PAGDCFRKQY EDQLAG
//
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