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Database: UniProt
Entry: A0A2D0QW90_ICTPU
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ID   A0A2D0QW90_ICTPU        Unreviewed;       371 AA.
AC   A0A2D0QW90;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   16-OCT-2019, entry version 9.
DE   SubName: Full=ATP-sensitive inward rectifier potassium channel 1-like isoform X1 {ECO:0000313|RefSeq:XP_017322687.1};
GN   Name=LOC108265089 {ECO:0000313|RefSeq:XP_017322687.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|Proteomes:UP000221080, ECO:0000313|RefSeq:XP_017322687.1};
RN   [1] {ECO:0000313|RefSeq:XP_017322687.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017322687.1};
RG   RefSeq;
RL   Submitted (NOV-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   RefSeq; XP_017322687.1; XM_017467198.1.
DR   GeneID; 108265089; -.
DR   KEGG; ipu:108265089; -.
DR   KO; K04995; -.
DR   OMA; SSPFFEM; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003268; K_chnl_inward-rec_Kir1.1.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF6; PTHR11767:SF6; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000221080};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|RefSeq:XP_017322687.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221080};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     60     83       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    137    161       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       24    166       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      173    340       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   SITE        152    152       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   371 AA;  42748 MW;  5CBDADA547DE5BB5 CRC64;
     MTRSLQQLFR HYLAKWHIYK NRLVRKDGHC NIEYGNVGYS NRFAYVQDLW TTFVEIRWRY
     IILLFVASFT LSWFIFGLIW YWIAHDNGDL WWQNPPSDHK PCIYNVFGLT SAFLYSLETQ
     TTIGYGQRVL SPYCPGAVAI IIIQSIIGLF INCFWCGLVM AKIALPKKRA KTITFSKMAV
     ICPKNAALCL QIRVANLRKT LMIGSQLYGK LLRTTITPEG ETIIMDQVNI DFSVDAGKDN
     LFFICPLTLY HVIDKTSPFF KFASDTLLQQ EFELVVFLDG IDESTSSSCQ VRTSYIPQEI
     KWGYKFLPII SRSKEGKYCV DFSNFDRVDP IPTAHCAHCF YNGQCHHHSP RNGIDNQGFE
     VIEIIDQISA N
//
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