ID A0A2D0QWZ1_ICTPU Unreviewed; 463 AA.
AC A0A2D0QWZ1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=RAR-related orphan receptor C a isoform X1 {ECO:0000313|RefSeq:XP_017322927.1};
GN Name=rorca {ECO:0000313|RefSeq:XP_017322927.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017322927.1};
RN [1] {ECO:0000313|RefSeq:XP_017322927.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017322927.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|RuleBase:RU004334}.
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DR RefSeq; XP_017322927.1; XM_017467438.3.
DR AlphaFoldDB; A0A2D0QWZ1; -.
DR STRING; 7998.ENSIPUP00000023103; -.
DR Ensembl; ENSIPUT00000024096; ENSIPUP00000023103; ENSIPUG00000015658.
DR GeneID; 108265285; -.
DR KEGG; ipu:108265285; -.
DR CTD; 559245; -.
DR OMA; IWQQCAV; -.
DR OrthoDB; 3475284at2759; -.
DR Proteomes; UP000221080; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06968; NR_DBD_ROR; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR044101; NR_DBD_ROR.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR003079; ROR_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR45805; NUCLEAR HORMONE RECEPTOR HR3-RELATED; 1.
DR PANTHER; PTHR45805:SF7; RAR-RELATED ORPHAN RECEPTOR C B-RELATED; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR01293; RORNUCRECPTR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 7..82
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 213..451
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 117..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 463 AA; 51822 MW; 915C5DD1DAF9D251 CRC64;
MRAQIEVIPC KICGDKSSGI HYGVITCEGC KGFFRRSQQN NATYSCSRQR NCMIDRTNRN
RCQHCRLQKC LALGMSRDAV KFGRMSKKQR DSLYAEVQKH QQGQECVSGV LSSGAVGVEE
PGENSHDGHT RTCSRSSSTA LSDLDDLGGL LFDLPLTPED EYCGLELQGN SRTSGEGSSG
GGDPSSHGSA VLKHEYQLLH THSPLNEGFS LLETERMAQS VVKSHVETSQ YSTEELKRLA
WNLYTAEETR TYQSKPMEAM WQQCVAHLTN AIQYVVEFAK RISGFMELCQ NDQIILLKAG
CLSVLLIQMC RAYNATNHTL LFDGKFASVQ LFKSLGCDDL VNAVFELAKS MSRLQLTEEE
MALFSAVVLF SPDRPWLTDR QPVQRLQGKV YQALQRCLNR EGANEHKLNK MLAKLPAIKS
ICNLHIDKLE FFRLLHPETA YSFPPLYREV FGSESTSPDS TKG
//
