ID A0A2D0QYL8_ICTPU Unreviewed; 596 AA.
AC A0A2D0QYL8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Nuclear receptor subfamily 2 group C member 2 isoform X2 {ECO:0000313|RefSeq:XP_017323492.1};
GN Name=nr2c2 {ECO:0000313|RefSeq:XP_017323492.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017323492.1};
RN [1] {ECO:0000313|RefSeq:XP_017323492.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017323492.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC subfamily. {ECO:0000256|ARBA:ARBA00006421}.
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DR RefSeq; XP_017323492.1; XM_017468003.3.
DR AlphaFoldDB; A0A2D0QYL8; -.
DR Ensembl; ENSIPUT00000034706; ENSIPUP00000033397; ENSIPUG00000022437.
DR GeneID; 108265548; -.
DR CTD; 7182; -.
DR OrthoDB; 5400963at2759; -.
DR Proteomes; UP000221080; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06967; NR_DBD_TR2_like; 1.
DR CDD; cd06952; NR_LBD_TR2_like; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR048245; NR2C1/2-like_DBD.
DR InterPro; IPR048246; NR2C1/2-like_LBD.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24083; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24083:SF48; NUCLEAR RECEPTOR SUBFAMILY 2 GROUP C MEMBER 2; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 115..190
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 341..583
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
SQ SEQUENCE 596 AA; 65541 MW; F8F2F7698BD704B0 CRC64;
MSASPQRIQI ISTDSSVTAP QRIQIVTDQQ TGQKIQIVTA VDPVSVPKQQ FILAAHDGTP
TGKVILASPN NPSTKQLIFT TADSLVPGRI QFVTDAVSVE RILGKGGEVG RPQPVEYCVV
CGDKASGRHY GAVSCEGCKG FFKRSVRKSL TYSCRSNQDC VVNKHHRNRC QFCRLRKCLE
MGMKMESVQS ERKPLDLPRE KPVNCAASTE KIYIRKDLRS PLIATPTFIT DKDGTRSGLL
DPGMLVNIQQ PVIQADGTLL LATDTKTETS HGDLGTLANV VTSLASLSES LNNGDGDISA
SQQEESVSEI TRAFDTLAKA LNPNEEGEGQ SLSEAECVGG ATIQVISRDQ VTPLIEVEGP
LLTDTHVNFK LTMPSPMPEY LNVHYICESA SRLLFLSMHW ARSIPAFLAL GQECNTSLVR
ACWNELFTLG LAQCAQVMSL STILAAIVNH LQSSIHEDKL SGERVKLVME HIWKLQEFCN
SMAKLETDGY EYAYLKAIVL FSPDHPGLNS SSQIEKFQEK AQMELQDYVQ KTYPDDTYRL
ARTLMRLPAL RLMSSSITEE LFFTGLIGNV PIDSIIPYIL KMETADYNSQ ISGPTA
//
