ID A0A2D0R037_ICTPU Unreviewed; 270 AA.
AC A0A2D0R037;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Homeobox protein Nkx-6.3 isoform X1 {ECO:0000313|RefSeq:XP_017323381.1};
GN Name=nkx6.3 {ECO:0000313|RefSeq:XP_017323381.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017323381.1};
RN [1] {ECO:0000313|RefSeq:XP_017323381.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017323381.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR RefSeq; XP_017323381.1; XM_017467892.3.
DR AlphaFoldDB; A0A2D0R037; -.
DR Ensembl; ENSIPUT00000014836; ENSIPUP00000014237; ENSIPUG00000009736.
DR GeneID; 108265506; -.
DR KEGG; ipu:108265506; -.
DR CTD; 558978; -.
DR OMA; EMKAPMC; -.
DR OrthoDB; 3234377at2759; -.
DR Proteomes; UP000221080; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR24340; HOMEOBOX PROTEIN NKX; 1.
DR PANTHER; PTHR24340:SF20; HOMEOBOX PROTEIN NKX-6.3; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}.
FT DOMAIN 148..208
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 150..209
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 205..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 270 AA; 29850 MW; 98545E181A0F566F CRC64;
MEPNLSGSLF FNNGLNQFPT DIKAPMCQYS VPNSFYKLSP GNLNAQLQAG TPHGISDILS
RSVVGAPANT ALLSGYSSMG GFSGTVPTPG VYYNRDYTPT TLGAFPKPSE CPGVKGRTSC
WVEGGYDWRG GRQQCSNLDS GHPGETVGRK KHTRPTFSGH QIFALEKTFE QTKYLAGPER
ARLAYSLGMT ESQVKVWFQN RRTKWRKKSA SEPSSTQASR AETQGASDTE LEDEEYNKPL
DPDSDDEKIR LLLRKHRRSF SVLRLGPHHV
//
