ID   A0A2D0R2G4_ICTPU        Unreviewed;       679 AA.
AC   A0A2D0R2G4;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=T-box brain protein 1b {ECO:0000313|RefSeq:XP_017324754.1};
GN   Name=tbr1b {ECO:0000313|RefSeq:XP_017324754.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017324754.1};
RN   [1] {ECO:0000313|RefSeq:XP_017324754.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017324754.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00201}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR   RefSeq; XP_017324754.1; XM_017469265.3.
DR   AlphaFoldDB; A0A2D0R2G4; -.
DR   STRING; 7998.ENSIPUP00000021568; -.
DR   GeneID; 108266223; -.
DR   KEGG; ipu:108266223; -.
DR   CTD; 58042; -.
DR   OrthoDB; 5323209at2759; -.
DR   Proteomes; UP000221080; Chromosome 6.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR   GO; GO:0009790; P:embryo development; IEA:UniProt.
DR   GO; GO:0060429; P:epithelium development; IEA:UniProt.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR   Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR032385; T-box_assoc.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267:SF88; T-BOX BRAIN PROTEIN 1; 1.
DR   PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR   Pfam; PF00907; T-box; 1.
DR   Pfam; PF16176; T-box_assoc; 1.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00201};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00201}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          208..393
FT                   /note="T-box"
FT                   /evidence="ECO:0000259|PROSITE:PS50252"
FT   REGION          29..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          588..653
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        610..628
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        639..653
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   679 AA;  73101 MW;  2785B3A6E45F4943 CRC64;
     MQLEHCISPA LALSKKCLSV GSGYPNSEGS DLALHGHPIT SARDNLERSS PLKKNSAGMT
     NQSEADNFAD SKDSSGDVQR GKLSPALDGV ADIRHNFDGS AGERYLLSQS SQTQPLAASP
     AAMFPYPSQH GPAHPAFSIG SPSRYMAHHP VITNGAYNSL LSNTSPQGYA SAGYPYAQQY
     GHAYQGAAFY QFSSAQAGLI PGKAQIYLCN RALWLKFHRH QTEMIITKQG RRMFPFLSFN
     ISGLDPTAHY NIFVDVILAD ANHWRFQGGK WVPCGKADTN VTGNRVYMHP DSPNTGAHWM
     RQEISFGKLK LTNNKGASNN TGQMVVLQSL HKYQPRLHVV QVNEDGTEDT SQPGRVQTFT
     FPETQFIAVT AYQNTDITQL KIDHNPFAKG FRDNYDTVYT GCDIDRLTPS PGESPRSQLM
     PSARYAAMPG SFLQDQFVSS YAKSRFHPGV GGAPGTDRGV PLGNSLLSPQ QTDETAVGSP
     QRWFVTPANN RLDFAASAYD AAAAADLAGN AATLLSYAAA GVKTLPLPAA GCSNRALGYY
     GEATAWGART PPQYCGKSGA VLPCWPSNSV PGRAAAAGYL VGLDEGDPAA PERSPLGAND
     DAKPKDLSES SWIETPSSIK SIDSSDSGIF EQAKRRRISP SATPVSETAS PLKSEMLTPR
     ECEKNCSKDI GYYSFYSHS
//