ID A0A2D0R3A5_ICTPU Unreviewed; 1198 AA.
AC A0A2D0R3A5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 2.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Potassium voltage-gated channel subfamily H member 8 isoform X1 {ECO:0000313|RefSeq:XP_017325083.2, ECO:0000313|RefSeq:XP_053536906.1};
GN Name=kcnh3 {ECO:0000313|RefSeq:XP_017325083.2,
GN ECO:0000313|RefSeq:XP_053536906.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017325083.2};
RN [1] {ECO:0000313|RefSeq:XP_017325083.2, ECO:0000313|RefSeq:XP_053536906.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017325083.2,
RC ECO:0000313|RefSeq:XP_053536906.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: The potassium channel is probably composed of a homo- or
CC heterotetrameric complex of pore-forming alpha subunits that can
CC associate with modulating beta subunits.
CC {ECO:0000256|ARBA:ARBA00011552}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_017325083.2; XM_017469594.3.
DR RefSeq; XP_053536906.1; XM_053680931.1.
DR STRING; 7998.ENSIPUP00000035402; -.
DR Ensembl; ENSIPUT00000036791; ENSIPUP00000035402; ENSIPUG00000023740.
DR KEGG; ipu:108266388; -.
DR OrthoDB; 66005at2759; -.
DR Proteomes; UP000221080; Chromosome 6.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0106151; F:CNBH domain intrinsic ligand binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:Ensembl.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IEA:Ensembl.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.1200.260; -; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR003950; K_chnl_volt-dep_ELK.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR10217:SF641; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 3 ISOFORM X1; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PRINTS; PR01465; ELKCHANNEL.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00086; PAC; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 231..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 515..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..90
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 93..145
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 617..734
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 758..884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 989..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1068..1117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1176..1198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..777
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..857
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 864..884
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1023..1051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1198 AA; 131656 MW; 3ACA7EFCCDFFA1B8 CRC64;
MPVMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVQSLY PIVYCSDGFC ELTGYARAEL
MQKSCACNFL YGPETSDRLT AQIQSALDDR REFKTELVFY KKGGTQFWCL LDIVPIKNEK
GEVVLFLVSH KDITDNKKDQ DEEQCPEIDE ETGLEVHKVT RPQSFNANRR RSRAVLYQLS
GHLQKQDKSK LKINNNMFGE KPPIPEYKVA AIQKSRFILL HYGTFKAGWD WLILLATFYV
AVTVPYNVCF AVVGVRDDMP TPRSPPSVSD ILVEILFMLD IVLNFRTTFV STSGQVVYDA
RSICVHYVTT WLFVDLIAAL PFDLLYAFNV SVFFGVHLLK TVRLLRLLRL LQKLERYSQY
SAVVLTLLMS MFALLAHWMA CVWYFIGRCE IENNTPGSWD IGWLHELAKR LGTPYFLSPL
TSVLPESLRP NNLDGLSGNV SQWNSSSSDI VGQDSVANST QLNGTGAGPV DGVDSVLGGG
PSVRSSYVTS LYFALSSLTS VGFGNVSANT DSEKIFSICT MLIGALMHAV VFGNVTAIIQ
RMYSRRSLYH TRTKDLKDFI RVHRLPKALE QRMLECFQTT WSVNNGIDVS ELLKDFPDEL
RADIAMHLNK ELLLLPLFES ASHGCLRSLS LIIKTSFCAP GEFLIRQGDA LQAIYFVCSG
SMEVLKDNTV LAILGKGDLI GSDSLTREQV IKTNANVKAL TYCDLQYISL KGLREVLRLY
PEYAQKFVSE IQHDLTYNLR EGNNTDVDWE SNGGLVKKLP SIREDEENDE EQHSVSRAPR
SPLRLTRGLS SPLRSPLMPP RPFRPPSDHS RPATLQIPVV SFSSAPPELS PRFVDGIETE
SNSGSAQRFE FSSNLPHSGP PSPSPVSQEQ VETRQSISKL SEEMNSLSKQ VSQLSEELQE
MTRLLRPLFL TAAQPLLSTP PPPMTLPGSG PSMNSPAAPY PPAPPCSLLD ITDPVGVVGL
PSCLIPTSPP QRLQSQVVCS NGSPHASLSH LETIKKDGTG TGQHDIPLGP TNGYGQVAPD
RLASRATSPS LSFSMSISSS RSQSPSLTPC QGPHPSCPTS CTQGLLFPIS SQDIPPASQD
NPPPPHSHCS APASLSNSPG DPRLRDGPSL ASSSSTPILQ TLPCSSPSCP HPSPLLLCSL
RDGQGSMGFP WHRQTSSCAQ AASGTEQPQL ELEMQEWDAG GKSSTEHISF IDEEGPPL
//
