ID A0A2D0R483_ICTPU Unreviewed; 475 AA.
AC A0A2D0R483;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Abl interactor 2a isoform X1 {ECO:0000313|RefSeq:XP_017325389.1};
GN Name=abi2a {ECO:0000313|RefSeq:XP_017325389.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017325389.1};
RN [1] {ECO:0000313|RefSeq:XP_017325389.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017325389.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, filopodium
CC {ECO:0000256|ARBA:ARBA00004486}. Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}.
CC -!- SIMILARITY: Belongs to the ABI family. {ECO:0000256|ARBA:ARBA00010020}.
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DR RefSeq; XP_017325389.1; XM_017469900.3.
DR AlphaFoldDB; A0A2D0R483; -.
DR STRING; 7998.ENSIPUP00000017770; -.
DR GeneID; 108266499; -.
DR KEGG; ipu:108266499; -.
DR CTD; 767646; -.
DR OrthoDB; 3028771at2759; -.
DR Proteomes; UP000221080; Chromosome 6.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR CDD; cd11972; SH3_Abi2; 1.
DR Gene3D; 6.10.140.1620; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR028457; ABI.
DR InterPro; IPR035726; Abi2_SH3.
DR InterPro; IPR012849; Abl-interactor_HHR_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR10460:SF26; ABL INTERACTOR 2; 1.
DR PANTHER; PTHR10460; ABL INTERACTOR FAMILY MEMBER; 1.
DR Pfam; PF07815; Abi_HHR; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 45..107
FT /note="T-SNARE coiled-coil homology"
FT /evidence="ECO:0000259|PROSITE:PS50192"
FT DOMAIN 413..472
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 156..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..383
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..399
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 475 AA; 52263 MW; E2E58CDE86EA91E8 CRC64;
MAELQMLLEE EIPAGRTALL DSFTNLERVA EYCESNYVQS PDKHRALEET KNYTTQSLAS
VAYLINTLAN NVLQMLDIQA SQLRRMESSI NHISQTVDIH KEKVARREIG ILTTNKNTSR
THKIIAPANP ERPVRYIRKP IDYNLLDDIG HGVKVGNQSM KMGGLPRTTP PTQKPPSPPM
PGKGTIGRHS PYRTLEPVRP PVIPNDYVPS PTRNMAPGQQ QSPVRTASLN QRNRTYSGSS
GGSHPSSRSS SRENSGSGSV GVPIAVPTPS PPNAFPGTAP QFYSMNRPVP RQITPPVGGS
LPYRRPPSVS SQPSMPASQQ NGGPYYNQGQ ASVAPPPPSI LQITPQLPLT GFVARVQETI
SDAPPPPPPT EESMLQEAQP PPPPLEDYEE EESSVVEYSD PYAEEDPPWA PCAYLEKVVA
IYDYTQDKED ELSFQEGAII YVIKKNDDGW YEGVMNGTTG LFPGNYVESI MHYRE
//
