ID A0A2D0R4G5_ICTPU Unreviewed; 1076 AA.
AC A0A2D0R4G5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Formin-like protein 2 isoform X3 {ECO:0000313|RefSeq:XP_017325493.1, ECO:0000313|RefSeq:XP_017325494.1};
GN Name=fmnl2a {ECO:0000313|RefSeq:XP_017325493.1,
GN ECO:0000313|RefSeq:XP_017325494.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017325493.1};
RN [1] {ECO:0000313|RefSeq:XP_017325493.1, ECO:0000313|RefSeq:XP_017325494.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017325493.1,
RC ECO:0000313|RefSeq:XP_017325494.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family.
CC {ECO:0000256|ARBA:ARBA00023449}.
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DR RefSeq; XP_017325493.1; XM_017470004.3.
DR RefSeq; XP_017325494.1; XM_017470005.3.
DR Ensembl; ENSIPUT00000032727; ENSIPUP00000031470; ENSIPUG00000021127.
DR GeneID; 108266543; -.
DR CTD; 100006456; -.
DR OrthoDB; 471257at2759; -.
DR Proteomes; UP000221080; Chromosome 6.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0022604; P:regulation of cell morphogenesis; IEA:InterPro.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR043592; FMNL_animal.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45857; FORMIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR45857:SF5; FORMIN-LIKE PROTEIN 2; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 2.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 22..458
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 612..1003
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 381..439
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 527..572
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..595
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1076 AA; 122430 MW; BEC884FB80DD4FED CRC64;
MGNAGSMEQH TDPRGHNMPL KLPMPDPGEL EERFAVVLNS MNLPPDKARL LRQYDNEKKW
ELICDQERFQ VKNPPHTYIQ KLKSYLDPAV TRKKFRRRVQ ESTQVLRELE ISLRTNHIGW
VREFLNEENK GLDVLVEYLS FAQYAVTFDG DSFENGTDNT MDKSKSWSRS IEDLHGGSSL
PSPIPGSISR AGRHSTLRCN TLPSRRTLKN SRLLCKKDDV HVCIMCLRAI MNYQYGFNMV
MSHLHAVNEI ALSLNNKNPR TKALVLELLA AVCLVRGGHE IILAAFDNFK EVCSENQRFE
KLMEHFRNED NNIDFMVACM QFINIVVHSV EDMNFRVHLQ YDFTKLCLDE YLDKLKHTES
DKLQVQIQAY LDNVFDVGAL LEDAETKNAA LERVEELEES MSHMTEKLQD TENEAMAKIV
ELEKQLMHKN KELDSIREVY KDASSQVHTL RRMVKEKDEA IQRQCNLEKK IHELEKQGTI
KIQKKGDGDI AILASAPSTN GLLAGTEGLP GGSMMGPLGP GSGVELGMSM PPPPPPPMPA
SLSIPNGPSA TLEPPPPPPP PPPPPPPPLP GSDISGEESS PMPPPPPPMA PPLPGCGSPT
VIFNSGLSAV KIKKPIKTKF RMPVFNWVAL KPNQINGTVF NEIDDERILE DLNVDEFEEI
FKTRAQGPAI DVTSSKQKTI QKLPNKISLL DSNRAKNLAI TLRKVGKTPE EICKAIQMFD
LRMLPVDFVE CLLRFIPTES EVKMLRQYEK ERKPLENLTD EDRFMMQFSK IERLVQKLTI
MAFVGNFGES VQMLTPQLHA IIAASVSIKS SQKLKKILEI ILALGNYMNS SKRGAVYGFK
LQSLDLLIDT KSTDRKLTLL HYIANVVKEK YQQVALFYNE LHYVEKAAAV SLENVLLDVK
ELQRGMDLTR REYSMHGHNT LFKDFIHLNE SKLKKLQDDA KIAQDAFDEV VKFFGENSKT
MPPSVFFPVF VRFVKTYRQA EEENEQRKRQ EQILMEKLLE QEAMEQENQK SPSHKNKRQQ
QELIAELRKK QVKDSRHVYE GKDGTIEDII TVLKTVPFTA RTAKRGSRFF NEELHC
//
