ID A0A2D0R508_ICTPU Unreviewed; 804 AA.
AC A0A2D0R508;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN Name=itgb5 {ECO:0000313|RefSeq:XP_017325688.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017325688.1};
RN [1] {ECO:0000313|RefSeq:XP_017325688.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017325688.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR RefSeq; XP_017325688.1; XM_017470199.3.
DR AlphaFoldDB; A0A2D0R508; -.
DR STRING; 7998.ENSIPUP00000032683; -.
DR Ensembl; ENSIPUT00000033974; ENSIPUP00000032683; ENSIPUG00000021957.
DR GeneID; 108266628; -.
DR KEGG; ipu:108266628; -.
DR CTD; 3693; -.
DR OrthoDB; 5475862at2759; -.
DR Proteomes; UP000221080; Chromosome 6.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 4.10.1240.30; -; 1.
DR Gene3D; 1.20.5.100; Cytochrome c1, transmembrane anchor, C-terminal; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR040622; I-EGF_1.
DR InterPro; IPR033760; Integrin_beta_N.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF26; INTEGRIN BETA-5; 1.
DR Pfam; PF18372; I-EGF_1; 1.
DR Pfam; PF08725; Integrin_b_cyt; 1.
DR Pfam; PF07965; Integrin_B_tail; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR Pfam; PF17205; PSI_integrin; 1.
DR PIRSF; PIRSF002512; Integrin_B; 1.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM01241; Integrin_b_cyt; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SMART; SM00423; PSI; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..804
FT /note="Integrin beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012655101"
FT TRANSMEM 725..747
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..80
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 39..468
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DOMAIN 640..724
FT /note="Integrin beta subunit tail"
FT /evidence="ECO:0000259|SMART:SM01242"
FT DOMAIN 748..795
FT /note="Integrin beta subunit cytoplasmic"
FT /evidence="ECO:0000259|SMART:SM01241"
FT DISULFID 32..468
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 40..50
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 43..79
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 53..68
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 207..216
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 264..305
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 406..418
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 438..687
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 466..470
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 489..527
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 494..503
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 505..518
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 533..538
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 535..568
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 540..553
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 555..560
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 574..579
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 576..607
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 581..590
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 592..599
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 613..618
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 615..663
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 620..630
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 633..636
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 640..649
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 646..719
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 667..695
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
SQ SEQUENCE 804 AA; 88832 MW; E9F34135D3E5C5BD CRC64;
MWSFRLCGHL AVLVAGIILH ICSHTARGLN VCVSGSATSC EECLLLHPSC AWCAQENFGR
GRTFMSQCDL SQNLLKRGCK ARYIENPRSF SSILKNKPLS SKGSMSAQYD VIQIQPQKIS
LSLRPGHQTS FELQVRPVED YPVDLYYLMD LSLSMKDDLD TIRNLGTKLA EEMKKLTSNF
RLAFGTFVDK NLSPFSYTAP KYKENPCNGY KPFPNCVPSF GFRNHLSLTD KVDRFNEEVQ
KQVVSRNRDA PEGGFDAILQ AAVCKERIGW RKEAYHLLVF ATDDVPHLAL DGKLAGLVQP
HDGQCHLNDE NEYSASTKMD YPSLALLGEK LAENNIFLIF AVTKRHYVLY KNFTALIPGT
TVEILDQSSK NIIQLIVTAY NNIRSKVELS VWDHPEDLSL AFTATCQDGK PLSGLSKCAD
LKIGDTVSFN ISVAAHSCPP PGTQKSFTIK PVGFKDSLEV SVDYQCDCNC TRFAQANSIH
CSYAGTYTCG TCHCNPGYHG KNCECEEEEV GSLNLAACRE AKGKQVCSGR GECSCNYCRC
YESEFGKIYG MYCECDDFSC ARHKGILCSG HGDCHCGECK CQAGYIGDNC NCSIETTGCV
SEDGRMCSGR GSCVCGRCQC TEPGAFGDLC EKCPTCGDAC AAKRECIECT LFNTGKFADN
HTCQRMCKDE IIVTETLNTD DPSTVLCLYK TENECVMKFT YSEHASGQSI LTALREPVCA
APPDAMTVLL AVVGSILLVG IVLLAMWKLV ITVHDRREFA RFQSARSRAR YEMASNPLYK
HPVSTHSVET AFQMYSKSYN GGLH
//
