ID A0A2D0R511_ICTPU Unreviewed; 2594 AA.
AC A0A2D0R511;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN Name=usp9 {ECO:0000313|RefSeq:XP_017324890.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017324890.1};
RN [1] {ECO:0000313|RefSeq:XP_017324890.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017324890.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
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DR RefSeq; XP_017324890.1; XM_017469401.3.
DR GeneID; 108266305; -.
DR CTD; 568683; -.
DR OrthoDB; 6206at2759; -.
DR Proteomes; UP000221080; Chromosome 6.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021905; DUF3517.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF827; UBIQUITINYL HYDROLASE 1; 1.
DR Pfam; PF12030; DUF3517; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|RefSeq:XP_017324890.1}.
FT DOMAIN 1559..1960
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 970..1001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1594..1615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2490..2594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2504..2518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2531..2575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2594 AA; 294781 MW; DD25F5450488FC9D CRC64;
MTATTRGSPM GGNESQEQGQ APDGQSQPPL PQNQTSTPTS SNENSPVSPP DEQVQGDCTG
QLEEEEEPAF PHTDLAKLDD MINRPRWVVP VLPKGELEVL LEAAIDLCKK GLDVKCEACQ
RFFRDGLTIS FTKILTDEAV SGWKFEIHRC IINNTHRLME LCVTKLSQDW FPLLELLAMA
TNPHCKFHIY NGTRPSETVP AGVQLAEDEL FARPPDPRSP KGWLVDLINK FGTLNGFQIL
HDRFMSGQAL NVQIIAALIK PFGQCYEFLT LHTVKKYFLP VIEMVPQFLE NLTDEELKKE
AKNEAKNDAL SMIIKSLKNL ASRVPGQEET VKNMEIFRLK MILRLLQISS FNGKMNALNE
VNKVISSVSY YTHRHGNPEE AEWLTAERMA EWIQQNNILS IVLRDSLHQP QYVEKLEKIL
RFVIKEKALT LQDLDNIWAA QAGKHEAIVK NVHDLLAKLA WDFSPEQLDH LFDCFKESWT
NASKKQREKL LELIRRLAED DKDGVMAHKV LNLLWNLAHS DDVPVDIMDQ ALSAHIKILD
YSCSQDRDTQ KIQWIDRFIE ELRSNDKWVI PALKQIREIC SLFGEAPQNL SQTQRSPHVF
YRHDLINQLQ HNHALVTLVA ENLSAYMENM RQFSKEHTDF DPQTVRPGSR YSHVQEVQER
LNFLRFLLKD GQLWLCAPQA KQIWKCLAEN AVFLCDREAC FKWYSKLMGD EPDLDPDINK
DFFENNVLQL DPSLLTENGM KCFERFFKAV NCREGKLVAK RRVYMMDDLE LIGLDYLWRV
VIQGSDDIAN RAIDLLKEIY TNLGPKLQAT QVEIHEDFIQ SCFDRLKASY DTLCVLDGDK
DSINCARQEA IRMVRVLTVL REYITECDSD YHEERTILPM SRAFRGKHIT LIVRFPNQGR
QVDDLDIWSH TNDTIGSVRR CILNRIKANS AHTKIELFIG GDIIDPADDR KLIGQLNLKD
KTLITAKLTQ VSANMPSSPD SSSDSSTGSP GNHGNHYSDG PNPEVESCLP GVIMSLHLRY
ISFLWQVADL GCSLNMPLLR DGARVLMKLM PPDNTTVENL RAICLDHAKL GESSLSPTLD
SRFFGPSPSQ VLYLIEVVYA LLMPASGTLG EDASDFQYNF LRSGGLPLVL SMLTRNNFLP
NADMETRRGA YLNALKIAKL LLTAVGFGHV KAVAEACQPV ADGNIPVSPI NQATHDQALV
LQSALQNIPN PSAECMLRNV AIRLAQQISD ENFFQASKYI PDIGVIRAVQ KIVWASGCGS
IQLVFSSIEE ISNIYEKTNA GNEPDAEDEQ VCCEALEVMT LCFALIPTAL DALSKEKAWQ
TFIIDLLLHC QSKSVRQMAQ EQFFLMATRC CMGHRPLLFF ITLLFTVLGS TAKERAKHAG
DYFTLLRHLL NYAYNSNINL PNAEVLLNNE IDWLKRIKDE VKRTGETGVE ETILEGHIGV
TKELLAFQTA EKKYYIGCEK GGANLIKELI DDFIFPASNV YLQYMKSGEF PPEQAIPVCS
TPATITAGFE LLVALAVGCM RNLRQIVDTL TDMYYSGCEA LTEWEYLPPV GPRPTKGFVG
LKNAGATCYM NSVIQQLYMI PPIRNGILAI EGTGSDVDDD MSGDEKQDNE SNVDPRDEVF
SYHHQFDDKP ALNKSEDRKE YNIGVLRHLQ VIFGHLASSR LQYYVPRGFW KQFRLWGEPV
NLREQHDALE FFNSLVDSLD EALKALGHPA MLSKVLGGSF ADQKICQGCP HRYECEESFT
TLNVDIRNHQ NLLDSMEQYV KGDLLEGANA YHCEKCNKKV DTVKRLLIKK LPPVLAIQLK
RFDYDWEREC AIKFNDYFEF PRELDMEPYT VAGVAKLEGS DVHPENQVIQ QNEPSEPEAP
CSSRYRLVGV LVHSGQASGG HYYSYIIQRN GSGSEGETNR WYKFDDGDVT ECKMDDDEEM
KNQCFGGEYM GEVFDHMMKR MSYRRQKRWW NAYILFYERM DSLDKDSELV KYISELTVSS
KPHQIKMPPA IECSVRKQNV QFMHSRMQYS LEYFQFIKKL LTCNSVYLNP PPGQEHLLPE
AEEMAKISIQ LAARFLFSTG FHTKKAVRGP ASDWYDALCI LLRHSKNVRC WFAHSALFSY
PNRFSEYLLE SPSAEVRGAF SKLIVFIAHF SLQDGPYPSP VASPGPSSQG CDNLSLSDHL
LRAVLNLLRR EVSEHGRHLQ QYFNLFVMYA NLGLAEKTQL LKLGVPATFM LVALDEGPGP
PIKYQYAELG KLYTVVSQLV RCCDVTSRMQ SSINGNPPLS NPYGDPSLTQ PIMPLHQLVA
EILFVRTSYV KKIIEDCSNS EETIKLLRFC CWENPQFSST VLSELLWQVA YSYTYELRPY
LDLLLQILLV EDSWQTHRIH NVLKGIPDDR DGLFDTIQRS KNHYQKRAYQ CIKCMVALFS
NCSVAYQILQ SNGDLKRKWT WAVEWLGDEL ERRPYTGNAQ YTYNNWSPPV QSNETSNGYF
LERSHSARMT LAKACELCPE ECHLTKHEVV SEEDAGRKLS SPQQLLPGEV TGQQQHTEQD
EQEAPDDQDS SPPEDTSLYP HSPGTQYQQQ NNLPHGQPYT GPAAQHMNNP QRPGPRAQEN
WEPPEEVPPA QTKE
//
