ID A0A2D0R6H2_ICTPU Unreviewed; 615 AA.
AC A0A2D0R6H2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Histone-lysine N-methyltransferase PRDM9 isoform X4 {ECO:0000313|RefSeq:XP_017326197.2};
GN Name=LOC108266884 {ECO:0000313|RefSeq:XP_017326197.2};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017326197.2};
RN [1] {ECO:0000313|RefSeq:XP_017326197.2}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017326197.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_017326197.2; XM_017470708.3.
DR AlphaFoldDB; A0A2D0R6H2; -.
DR OrthoDB; 3994754at2759; -.
DR Proteomes; UP000221080; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd19193; PR-SET_PRDM7_9; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 10.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR044417; PRDM7_9_PR-SET.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24393:SF100; LOW QUALITY PROTEIN: ZINC FINGER PROTEIN 595-LIKE-RELATED; 1.
DR PANTHER; PTHR24393; ZINC FINGER PROTEIN; 1.
DR Pfam; PF21549; PRDM2_PR; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 6.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 115..229
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 261..289
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 329..356
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 357..384
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 385..412
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 413..440
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 441..468
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 469..496
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 497..524
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 525..552
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 553..580
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 581..604
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 615 AA; 70806 MW; DA0B64BD1B0A5960 CRC64;
MSSAGDGPHS SRTSHADDPS QGETSDGGTS GGTEVCVKKE ETLDLHIYNH GENHKNIPEV
ISTKEEETYN EDYLYCEVCK SFFFNKCEVH GPALFITDTP VPMGVADRAR QTLPPGLEIR
KSGIPDAGLG VFNIGETVPV GAHFGPFQGE LVDREEAMNS VYCWVVYRSR HCEEYIDAKR
EMYANWMRYV NCAHNGEEQN LVAFKYQGKI LYRCCRPIDS GQELFVWYDE EYAKDLRHTC
DYHRSTKSST NEVNNDLLQV FSCSLCTFSC TSQIDLNKHV QSYHYEEYPR QQKSEIIKYE
IQVATNGSSD QQTSSGSNTP QKEMEEKIHN CSECGKSFTD QNALKAHQCN QTGEKPYRCS
YCGKSFNHKS VLRKHQRIHT GEKPHRCSQC GKSFIQKSDL QQHQRTHTGE RPYYCSMCGK
SFSHHSHLQL HQRIHTGEKP FQCSQCGKRF TQKSNLQVHQ RVHTGEKPYH CSHCGKNFTL
QSNLQLHQRI HTGEKPHHCS HCGKSFTHQS TYQRHQRIHT GEKPYYCSEC EKCFNHQSHL
QRHQRTHTGE KPYHCSQCGK SFSQQSSLHV HQRIHTGEKP YHCSQCGKRF TYSLTFKTHK
CTNTDPLHYL NYLSN
//
