ID A0A2D0R9F5_ICTPU Unreviewed; 345 AA.
AC A0A2D0R9F5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=tRNA methyltransferase 10 homolog B {ECO:0000256|ARBA:ARBA00035688};
DE EC=2.1.1.221 {ECO:0000256|ARBA:ARBA00012797};
DE AltName: Full=RNA (guanine-9-)-methyltransferase domain-containing protein 3 {ECO:0000256|ARBA:ARBA00035712};
DE AltName: Full=tRNA (guanine(9)-N(1))-methyltransferase TRMT10B {ECO:0000256|ARBA:ARBA00035725};
GN Name=trmt10b {ECO:0000313|RefSeq:XP_017326460.1};
GN Synonyms=rg9d3 {ECO:0000313|RefSeq:XP_017326460.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017326460.1};
RN [1] {ECO:0000313|RefSeq:XP_017326460.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017326460.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=guanosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-
CC methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:43156, Rhea:RHEA-COMP:10367, Rhea:RHEA-COMP:10368,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:73542, ChEBI:CHEBI:74269; EC=2.1.1.221;
CC Evidence={ECO:0000256|ARBA:ARBA00000855};
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DR RefSeq; XP_017326460.1; XM_017470971.3.
DR AlphaFoldDB; A0A2D0R9F5; -.
DR STRING; 7998.ENSIPUP00000012167; -.
DR GeneID; 100528392; -.
DR CTD; 158234; -.
DR OrthoDB; 2908056at2759; -.
DR Proteomes; UP000221080; Chromosome 7.
DR GO; GO:0052905; F:tRNA (guanosine(9)-N1)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd18100; Trm10euk_B; 1.
DR Gene3D; 3.40.1280.30; -; 1.
DR InterPro; IPR028564; MT_TRM10-typ.
DR InterPro; IPR038459; MT_TRM10-typ_sf.
DR InterPro; IPR047911; Trm10_B_MTase_dom.
DR InterPro; IPR007356; tRNA_m1G_MeTrfase_euk.
DR InterPro; IPR016009; tRNA_MeTrfase_TRMD/TRM10.
DR PANTHER; PTHR13563; TRNA (GUANINE-9-) METHYLTRANSFERASE; 1.
DR PANTHER; PTHR13563:SF19; TRNA METHYLTRANSFERASE 10 HOMOLOG B; 1.
DR Pfam; PF01746; tRNA_m1G_MT; 1.
DR PROSITE; PS51675; SAM_MT_TRM10; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|RefSeq:XP_017326460.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 136..334
FT /note="SAM-dependent MTase TRM10-type"
FT /evidence="ECO:0000259|PROSITE:PS51675"
FT REGION 78..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 345 AA; 40312 MW; 160ABA1B13ADED04 CRC64;
MGHYCYRQTK CIVEMNEPVE IVDKQKWSFE DRHLNDEYVS GMMEFLSIDV DLSPGSSNRE
ETLCSKNVMR KQRNWERRLE AKKSKRKEEK QRRKQNQQDK ADVSQFSKRV IKAITRERLE
EARAAGPRLC VDLSMTDCMS HKRWGSLLDV YMVITPEVPL QICNEISRLA SQIRRLYGSN
RKAMQPFHLF LTDMKEDSLL YKECIRMNEG FLNYLIDVTE ESWIELFPCE DIIYLTPDAS
EALEEVNGDK VYILGGLVDE SIQKKRTYTR AKELGVQMMR LPIDEYMMKR PNPKNFHSKI
LAINQVFEIL LTYRDTGSWS KALSAGVPTG KGYIVSSEAE LDFPW
//
