ID   A0A2D0RBC4_ICTPU        Unreviewed;      1984 AA.
AC   A0A2D0RBC4;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1 {ECO:0000313|RefSeq:XP_017327848.1, ECO:0000313|RefSeq:XP_047012616.1};
GN   Name=smchd1 {ECO:0000313|RefSeq:XP_017327848.1,
GN   ECO:0000313|RefSeq:XP_047012616.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017327848.1};
RN   [1] {ECO:0000313|RefSeq:XP_017327848.1, ECO:0000313|RefSeq:XP_047012616.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017327848.1,
RC   ECO:0000313|RefSeq:XP_047012616.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_017327848.1; XM_017472359.3.
DR   RefSeq; XP_047012616.1; XM_047156660.2.
DR   STRING; 7998.ENSIPUP00000010041; -.
DR   GeneID; 108267874; -.
DR   KEGG; ipu:108267874; -.
DR   CTD; 23347; -.
DR   OrthoDB; 5388904at2759; -.
DR   Proteomes; UP000221080; Chromosome 7.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR   GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR010935; SMC_hinge.
DR   InterPro; IPR036277; SMC_hinge_sf.
DR   InterPro; IPR038892; SMCHD1.
DR   PANTHER; PTHR22640:SF2; STRUCTURAL MAINTENANCE OF CHROMOSOMES FLEXIBLE HINGE DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR22640; UNCHARACTERIZED; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF06470; SMC_hinge; 1.
DR   SMART; SM00968; SMC_hinge; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF75553; Smc hinge domain; 1.
PE   4: Predicted;
FT   DOMAIN          1711..1835
FT                   /note="SMC hinge"
FT                   /evidence="ECO:0000259|SMART:SM00968"
FT   REGION          1945..1984
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1957..1984
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1984 AA;  222642 MW;  8EE3A4EA1725CEAA CRC64;
     MAESGVPAAE TSQVSRSVLV FDCRPENKEA SGKMLDIGGT SYKQFLCAVR KEFSISVNES
     FVITTTDRRE IDSDVYEELS DGKTLHLLKS LDQELVVATE ERINYVPHFH TIVQSGQYEY
     YASEGQKALP YAFAELIDNA LSATAHNPET RSIDIRLFFD ESQGGPAVVV MDNGRGMTSK
     ELNNWAVYRL SKFNRDDRTF RSDKSGYVRP SAVPRSLNSD ISYFGVGGKQ AVFYIGQSVR
     IISKPGGSPD VHEFVMSKED FEQKEKNNKE IYCGIIRNRK PADDSHVIVD EERFLQSLVL
     EEKGKDSFTA IVITAVQPEH VAYLKKDFDS WTRELAHIYH YYIHGIYGND MSDNRTPVTT
     SNIDIQICLI ERSPRLPRLL NLKEIDNDMQ TLYINSSVAE FEFKASRGGD AKVEGLLRYH
     PFLYDRETYP EDPCAVKPAL ESDEDCFVLH AEGRGKRPIF ECFWNGRLIP YSSVDEFEWC
     ERPKKVSSVP LECYNRISGV LFTNDHFKVS TNKLTFMDLE LQLRDKETIF TRVLNGQEQR
     VQIKREFANW LKECHERHDK QVKFLGFQGV MTRPDIQPKR LQSPWARYKA IVWDGKTYKS
     GQKVKTMKTS PIVYGTVSQF LLYGDHEGDV YATGGHVQIV VEPKEVYNEV KIMPITKIDR
     QASNADIKEN IEKELDKLPD KLRVTWPKKN PWSEKDVRPA GTPMGPIKVE ILNKKGETMS
     RWPVSSGNSR KFMIDLKVVW HSPDKAITTN SHIGVHSKWE YWFRPMENLN KLGTYTLHLQ
     TILSDGDSPM TEWAGTQLPH YTLNFSIKEG SAAAFVTGVV PSPVQVGVPF PLPLQFTDEF
     NHPTLPPSGI KPQLECSSLT LSYEQTTSKD STFTIQDLKA MGKLTDHQVK IHTVKVMIPG
     LNPESQTFQI SVRPGPPHHL VVKPTDEVCI ENGTSAGFRV EVQDEFHNVT THSSLIVRCQ
     LFGASDLPAD TVDCSNTGSG LLLAKPIQLK NVTTERILTA KFGIPNLKAV ACVERRIRIL
     PSTRVFRIEV YRQEDDSDDV MVLQNKECIN WTAGDTLGSL RFKLYDEGGR QVALTQRLAH
     NIKVNWTADL KAAELAKGRL PCVCVPTKTN GEQFYQVAFQ DQHTVDTSFT IIPRPDEPDR
     LKVTLSETTV RMSETLSANI YVEVIDQYGN KTDALNAESM KAVSVSADNL DESALKFDWQ
     TSTGTMVVTG VRFAEGFPGP RQLCFKYQNF NGFVSVNVTA GPPTKITLLE APELPLCVLN
     GHGIATPFVL QLCDEWGNPV PDQRVVIAIK TLSPQLKVKS SVMSQPVNAE GKASFILETI
     TATIGDHELE FRGSFSRNKT ISGPVVKLSV MPDPNNPVKL CVEYDSEAIL RAGDLFPVFK
     VTILSEEGGP VKNVSPSSLS MLLWQGLASG SRPPPTAVAL KCSKPKDKEN DDHFYFRDKE
     IPSRVGKYML QFLFAVENGK SLWSSQIALD IVANKPVKLV PDTPASTPVV SNSSTLANRT
     LLQFLCLKIM DKHNNPAGMG INGKVILTVT TVDGDDAEGL PMFENKAKSL TYNLLNGETR
     ITVLALMENS PGADGAVYTL QFRPVLEGPK SNPTIPPFNL PFRFYNDAEN QKAMAAMSKK
     KDQLSQSIEV YKAILETNKQ LTTELKGQVQ DAVSKEAQLK SELKNSGIDI SKLTDVESVE
     NLIDQMTAHL VALQNLPRRK CTMPDPFRGS HDVLGKIAHL ALVKDDDAAK VISWHILGDM
     DCVVTVTTAA AKKIYDDTKG RQQVMPLETI FWKPNNRPLP HIKNGQSLFP PLGNPVFARD
     LLFFPDHAES CNMVFTNVLG DTILVDDLDS ANHYRKRVVQ SKMQCPTLLT RQGDRIRSNG
     KFGGLQNKAP PIEKLRGHVF GAPLPHEYHT ICKQKELLQQ YSVAVQKALK VKDDYDNHVQ
     SPQMKQKQQE LQQQEKELRD IEKMLTSTPV RTSPGSIKRK LQHDVDESLP AKRIRRKTRK
     LLDP
//