ID A0A2D0RC81_ICTPU Unreviewed; 274 AA.
AC A0A2D0RC81;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Insulin-like growth factor-binding protein 1 {ECO:0000256|ARBA:ARBA00013675};
GN Name=igfbp1b {ECO:0000313|RefSeq:XP_017328149.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017328149.1};
RN [1] {ECO:0000313|RefSeq:XP_017328149.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017328149.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and
CC have been shown to either inhibit or stimulate the growth promoting
CC effects of the IGFs on cell culture. They alter the interaction of IGFs
CC with their cell surface receptors. Promotes cell migration.
CC {ECO:0000256|ARBA:ARBA00025468}.
CC -!- SUBUNIT: Binds equally well IGF1 and IGF2.
CC {ECO:0000256|ARBA:ARBA00011863}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR RefSeq; XP_017328149.1; XM_017472660.3.
DR AlphaFoldDB; A0A2D0RC81; -.
DR GeneID; 108268024; -.
DR KEGG; ipu:108268024; -.
DR CTD; 793907; -.
DR OrthoDB; 5394492at2759; -.
DR Proteomes; UP000221080; Chromosome 7.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR CDD; cd00191; TY; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR022322; IGFBP1.
DR InterPro; IPR022321; IGFBP_1-6_chordata.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR11551; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN; 1.
DR PANTHER; PTHR11551:SF6; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR PRINTS; PR01976; IGFBPFAMILY.
DR PRINTS; PR01977; IGFBPFAMILY1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..274
FT /note="Insulin-like growth factor-binding protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012767996"
FT DOMAIN 30..111
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 190..268
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
SQ SEQUENCE 274 AA; 29607 MW; D8C9B5367ADDF68D CRC64;
MRGLVLISTL GFILILIPAP AEQSPVPELV PIRCAPCTPE KLSACPAAPS GCRELMKEPG
CGCCMTCALP EGALCGVYTA HCGTGLRCTP KEDDPQPLHS LTRGQALCTV DRSAQGASLL
STAEPPYLDQ REAEKLHDLM LNHNRLLTEE SGEHGFSLHQ LLGLDKAGDP EAHESIRAKV
NAIRKKLVEL GPCHTELHSA LDRIMASQHA LGEKFTTFYL PNCDTNGFYK TKQCETSLVG
QAARCWCVSA WNGKRITGSS DVPVDALCHQ EITH
//
