ID A0A2D0RCA4_ICTPU Unreviewed; 1341 AA.
AC A0A2D0RCA4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Tyrosine-protein kinase receptor {ECO:0000256|RuleBase:RU000312};
DE EC=2.7.10.1 {ECO:0000256|RuleBase:RU000312};
GN Name=insra {ECO:0000313|RefSeq:XP_017327756.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017327756.1};
RN [1] {ECO:0000313|RefSeq:XP_017327756.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017327756.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171,
CC ECO:0000256|RuleBase:RU000312};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. Insulin receptor subfamily.
CC {ECO:0000256|RuleBase:RU000312}.
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DR RefSeq; XP_017327756.1; XM_017472267.3.
DR STRING; 7998.ENSIPUP00000022262; -.
DR Ensembl; ENSIPUT00000023214; ENSIPUP00000022262; ENSIPUG00000015045.
DR GeneID; 108267827; -.
DR KEGG; ipu:108267827; -.
DR CTD; 245699; -.
DR OMA; FFILCTC; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000221080; Chromosome 7.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0043560; F:insulin receptor substrate binding; IEA:InterPro.
DR GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IEA:InterPro.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd00064; FU; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR040969; Insulin_TMD.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016246; Tyr_kinase_insulin-like_rcpt.
DR InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR PANTHER; PTHR24416:SF535; INSULIN RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF17870; Insulin_TMD; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR PIRSF; PIRSF000620; Insulin_receptor; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00261; FU; 2.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR000620-2, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00023137};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000620-2, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|RuleBase:RU000312};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000312};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000312};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1341
FT /note="Tyrosine-protein kinase receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012880988"
FT TRANSMEM 934..956
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 614..715
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 827..924
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 995..1270
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 672..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1131
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000620-1"
FT BINDING 1005
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000620-2"
FT BINDING 1029
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000620-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
FT BINDING 1076..1082
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000620-2"
FT BINDING 1135..1136
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000620-2"
FT BINDING 1149
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000620-2"
SQ SEQUENCE 1341 AA; 151154 MW; C6C75C667B210409 CRC64;
MKLGSLFGFV MCLGVVWNWP QSSAEICPSK DIRNNVTNLH SLENCTVIEG HLKILLMFHT
KAEDFRGLSF PKLTVVTDYL LLFRVYGLES LSDLFPNLTV VRGNNLFFNY ALVIFEMLQL
KEIGLHSLMN ITRGAVRLEK NPDLCYLSTL DWSQILDSVE DNYIVANKNE GECGDVCPGM
AKGKTICPQT TINGQFGARC WTQRHCQQMC PSVCKARACT LDGQCCHSEC LGGCVKPDSA
AGCVACRHFL HAGVCVEACP SGSLSFKGWR CISPAYCHAL HTQCTRNTQD KDCHSYVIHQ
GACVPECPSG YTTVNSTTLT CTPCAGMCPK VCVGEKTVDS VTAAQALRGC TLLNGSLTIN
IRGGNNIAAE LEANLGQLEE ITGYLMVRRS YALVSLSFLR KLRLIRGEIQ ERGNYTFFAL
DNQNLRQLWD WSKHNVSILQ GRMFFHHNSK LCLSEIRRME EVTGTRERQP KNDIGFKTNG
DQASCEYRVL KFTMIRTLAD KIVIKWEPFW PPDFRDLLGF MVLYKEAPYR NVTEFDGRDA
CGSHSWVIAD VDPPQRYSDG RQQQEPGFLI VALKPWTQYA IMVKAQLSTS DEHQVQGAKS
PIIYVRTNAT KPSVPLDPIS SSNSSSQIIL KWKPPNDPNG NITHYIVSCL QQPEASELYK
FDYCQKGMKL PSRAPTQVDS KEGQKWNQTE ESGQNELCCP CPKTEKQLKK ESEESEYRKT
FENYLHNEVF RIRPSRQRRS LVGVANSTIS TSLTTPTTLP SLSPEEEAES NKIIQSVYGK
ETTVISNLKH FTSYQIEIHA CNNQPGDPER CSMAAYVSAR TLPEDHADDI LGKIVFNVVE
YSVHIKWAEP KAPNGMIILY EVNYKRLGDT EELSHCVSRK HYISDGGCKL RVVHPGNYTV
RIRATSLAEN GSWTEPEYFY IKDLRVDPSN MIKIIVVPLV CVVLVVLMAM AGFIMVRKKQ
AEGPTGRLYT SPNPEYLSPD EMYEPDEWEV AREKITLLRE LGQGSFGMVY EGVAHDVVKG
EAETCVAVKT VNEAASLRER IEFLNEASVM KSFSCHHVVR LLGVVSKGQP TLVVMELMTH
GDLKSYLRRL RPDSENNPGR PPPTLREMMQ MAAEIADGMA YLNAKKFVHR DLAARNCMVS
EDYTVKIGDF GMTRDIYETD YYRKGGKGLL PVRWMAPESL KDGVFNAHSD CWSFGVVLWE
ISTLAEQPYQ GLSNEQVLKF VMDGGFLERP DNCPDRLHSL MQMCWHYNPK LRPAFQEIIE
MLRDELHPSF TDLSFFYSEE NRIRARDSDD FDMDLENMES IPLSSYSPGD EGTYEGLIPY
THMNGGKKNG RVLSLPRSSP S
//