ID A0A2D0RCS2_ICTPU Unreviewed; 4505 AA.
AC A0A2D0RCS2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Dynein axonemal heavy chain 2 isoform X1 {ECO:0000313|RefSeq:XP_017328344.1, ECO:0000313|RefSeq:XP_017328345.1};
GN Name=dnah2 {ECO:0000313|RefSeq:XP_017328344.1,
GN ECO:0000313|RefSeq:XP_017328345.1, ECO:0000313|RefSeq:XP_017328346.1,
GN ECO:0000313|RefSeq:XP_017328347.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017328344.1};
RN [1] {ECO:0000313|RefSeq:XP_017328344.1, ECO:0000313|RefSeq:XP_017328345.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017328344.1,
RC ECO:0000313|RefSeq:XP_017328345.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_017328344.1; XM_017472855.2.
DR RefSeq; XP_017328345.1; XM_017472856.2.
DR RefSeq; XP_017328346.1; XM_017472857.2.
DR RefSeq; XP_017328347.1; XM_017472858.2.
DR GeneID; 108268123; -.
DR KEGG; ipu:108268123; -.
DR CTD; 146754; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000221080; Chromosome 7.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF32; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1867..2003
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2146..2282
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2484..2631
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3090..3181
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3303..3358
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3610..3637
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 7..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4505 AA; 515342 MW; 05D4A0CF98F45EA5 CRC64;
MAEPETPHTE LSSSSESKHS STGKRPSLPA SDKSVLEGSD SQPAVGDLNK ETILAEEEDA
HTKGLRELLK RRVALTGVSV ASWTDENNGA LDKFIADATI KLLIIFLDPF SGLCVQYTMP
SQVVEQLAYF IRKQDTMIME ETFESCVQFG TVRGGGIESL LRLMNGIHAP LVTHSTDWPE
TIMNNYLPHM HRFITYLTDA RFRLGRKTLL YIPLEALQHS PEVAARDKEL VKRLEVVVIH
WTRQIKEVLN VQAAVDAGDS SGLLDEITFW MNRCDDLSGI SEQLQKPGVC HIQAILQLSM
SFYVKPFCNL AKEIQDGFLQ AQSNLTFLCL LREPCEELSQ LKPRQIAHKL GHVLNLIRFI
WVNSPHYNIP ARITVLLMKM NNEIIRWCSK EISLKRIFQG YVTSSKETLN DCIYCCLSWQ
KRYQLTAQLH DMHSQEGWEL SQSRIFSSLD GFVQRCTQLL EVCDCQRQFA RRDEGVQLPL
PCIAGHQGPE ITRKLLKIEA MFDKTLQNLY YECEGIFELK NTTWHNSCNR FRSAVKELEL
MMQNLINTAF MTVRTVDNGI QLLDLFHQFS AREAIRGTLD RQSKVYSLFT KDLDLMKTKL
GQKEVCTPAH MPQYAGQAHW VRAMHRRIDR QMEVLQHACF MPQNDTGQDV HEAYRQPAHT
MDERIRKLFS DWSQSLDHHM LKGLDQPLMI RCKGKTVMLD INFNKSILKM FNEIHYWERL
KFEVPHFVAE IRQRREDLRT LRENVLLLVK DYNRIIAALS PDTLGLFQER IHFLDKKIQP
GLSKLLWSSK GATSLFINDC RLHASKVQLL VDEYKAAHLA ISQRCSEISE VLLVHVDGKT
VYKDLEFEQV QQGHQQSQLR RLKTAHQDII DIMSRIYEIF HNDGPKVQQH WVTYTEKMDC
MVEDALRLNV KCSLQALSKA INGDSKTSPN PLFRVQVVLR QDTSGSTAQV DFSPTLHKLA
QIVNSISSQL FNAVSGFKRL PELFTRVRSQ RKPVHSITEQ DEEICKIQSA IAAGMTANAT
HLQAYLKTWD KHREIWEIKK DPFIRRYERL NPPVSTFDAD IARYTEVANN VQKEETVLNV
QFVLLDCSPL KFSLVQHCNE WQNKFTQLLS LMASTRLKEL HCYLHDSAQR LSQTPQTLDE
LVESLKLLET LQGDVSKTES QIAPIQEQFA ILEKYEVTVE REIQEMLEAL NGKWEWFQQV
LIDSSVTLKK HKEKFKSGLI FSAEEFNKKA QSVMQDFNIT GPFGSNVSSG EALEYISLLK
AQLESLKEEE NTICHGLGVF MIDQPVSTDI LRLEKDLDDL QQVWEITQQW ETHWNEWKSG
QFATLQTESM EITAQTIFKK LHKLSRDLKD KQWDIVDFSK NRIEQFKRTI PLILDLKNPA
MRKRHWSQIK HEVQRSFDQS SAEFTLEEIV VLGLDHYAER ICEISGAASK ELSIEQSLKG
IAKTWEEISL DIAPYKDKGH HRLRGTEEVF QALEDNQVTL STMKASRFVR AFEKEVDHWE
RCLSLILEVI EMILTVQRQW MYLENIFLGE DIRKQLPHES AEFDDINSSW KTIMDRLNQD
KNALRGTQHP GLPEKLSEIN TKLEEIQKSL DMYLETKRQI FPRFYFLSND DLLEILGQSR
NPDAVQPHLK KCFDNIKSLR INKIGPGSMK SEAAGMFSAD GEFVEFTHPV LLEGPVEVWL
CDIERAMRWT LKDSLKNCCL ALKKMIGKRD KWVKDWPGQM LITASQIQWT TDVTKSLIAG
KERADKSALK SMKKKQVSML HRYSESIRGN LSKVMRLKIV ALVTVEVHAR DVIDKLAKTG
CCDMNAFDWL CQLRLYWDKD VDDCIIRQTN THFQYCYEYL GNSGRLVITP LTDRCYMTLT
TALHLHRGGS PKGPAGTGKT ETVKDLGKAL GMYVIVINCS DGLDFKSMGR MYSGLAQIGA
WGCFDEFNRI NIEVLSVVAQ QILSILSALS AGATNFIFEG REIRLVSSCG IFITMNPGYA
GRTELPDNLK SMFRPVSMVV PDSTLIAEIT LFAEGFNNCK VLAKKVFTLY SLAVQQLSKQ
DHYDFGLRAL TSLLRYAGKK RRACPDVADE EILLMSMKDM NIAKLTSVDV PLFNGIIQDL
FPAVETPTID YGKLRETIEA ELRQHGLQVT PFTLNKVIQL YETMNSRHSS MIVGKTGSGK
TVTWRILQNT LNTMHRRGEP GFNLVRVYPL NPKAVSLGEL YGEYDLSTNE WTDGVLSSLM
RAACADEKPD EKWIVFDGPV DTLWIESMNS VMDDNKVLTL INGERISMPE QVSLLFEVED
LAMASPATVS RCGMVYNDYS DLGWQPYVQS WIDKRQKGEV DHLKRLFDRY IEKTISFRKA
HCKELVPITE LNGVVSLCRL YDSLASPENG FPLSLQLNPD DTENYGRMIE LWFIFSLIWS
VCASVDEDGR KKMDNFLREM EGTFPNKDTI YEYYVDTKNK TWSSFDDKLP KGWRYNSNAP
FYKVMVPTVD TVRYNFLVNA LICGQNPVLL TGPVGTGKTS VAQSVLQGLD PSKWTMLTIN
MSSQTTSNNV QAIIESRVEK RTKGVYVPIG GKKMVAFLDD INMPAVDDFG SQPPLELLRL
WIDYGFWYDR QKQTQKCVKD MFLLSSMGPP GGGRTRISGR LQSRFNLINM TFPAESQIKR
IYGTMINQKL QEFEEEVKPI GNVLTQATLE LYYAISARFL PTPAKIHYLF NLRDISKVFQ
GLLRSHKDFH DTKQSITRLW IHECFRVFSD RLVDQADMEA FVGLLTEKLG SLFDLTYHNL
CPNKQPPIFG DFLKEPRVYE DLVDFKSLKR FLESQLEDYN LTPGVVPMSL VLFRDAIEHV
TRVMRVISQP RGNMLLVGVG GSGRQSLTKL ATYICDYLLF QVEVTKQYRK PEFREDIKKL
YRLTGVDNKP SVFLFNDTQI VDESFLEDIN NILSSGEVPN LYKPDEFEEI LSALTESARK
DNVSETPDSM FNYLIERVRN NLHIVLCMSP VGDPFRNRIR QYPALVNCTT IDWFSEWPQD
ALLEVAERYL HGLTLGNEEG TQTKVACIFV TMHQSVVQFS QRMKLELKRH NYVTPTNYLE
LVTGYKKLLA EKRGELGEQV SKLRNGLFKI DETRSKVEAM SVELEDSKKK VAEFQKQCEE
YLVIIVQQKR EADEQQKAVS AHSEKIAAEE IKCKAMADNA QRDLDEALPA LEEAMKALES
LNKKDMTEIK SYGRPPALVE TVMQAVMILR GCEPTWAEAK RQLGEASFIK QLVHFDKDNI
SDRVLKKIGQ YCTQPDFQPD IIGRVSLAAK SLCMWVRAMD VYGRIYRVVE PKRARLHGAM
TQLAEKQTSL AEAQTKLREV GEKLDQLQTQ YSEKLSQKED LRKKSEDMEL KLDRAGKLVS
GLAGERVRWE KTVEDLEMDM GYLVGDCLLA AAFLSYMGPF LSNYRDELLT RIWIKQFKEL
EVPCSPGFSF AVFLSKATAV RDWNIQGLPS DAFSTENGVI VTRGNRWPLM VDPQGQALKW
IKNMESKRSL KVIDLQMPDF LRVLENAVQF GSPVLLQNVQ EDLDPSLAPI LNKSLSHVGG
RLLMKLGDKE VEYNPEFRFY ITTKLSNPHY TPEISSKTTI VNFAVKEQGL EAQLLGIVVR
KERPELEEQK DSLVINIASG KRKLQELEDE ILRLLNEATG SLLDDVQLVN TLQTSKVTAT
EVSEQLQTSE QTEIKIDTAR EAYRPCAQRA SILFFVLNDM SHIDPMYQFS LDAYIDLFNL
SIEKSLRSHK LDERIAKLND YHTYAVYRYT CRGLFECHKL LFSFHMCAKI LEVAGKLNMD
EYSFFLRGGL VLDKEGQMDN PCSSWLADSN WDNITELDKL ANFHGLMASF EQYPRDWNLW
YTSSEPENAP LPGEWENGCN ELQRMLIVRS LRQDRVSFCV TSFIINNLGS RFVEPPVLDM
QAVVEDSTTK APLIFVLSPG VDPTAALVQL AEKSGMGHHF YALSLGQGQA PIATRMIKEG
VKNGHWVFLA NCHLSLSWMP QLDKLVEQLQ VEDPHPDFRL WLSSSPHPDF PISILQAGIK
MTTEPPKGVK SNMKRLYRLV TESQFSRCTQ PIIYRKLLFA LCFFHSILLE RKKFLQLGWN
IVYSFNDSDF EVSENLMSLY LDEYEEIPWD ALKYLIAGIN YGGHVTDDWD RRLLTTYISD
YFCEGTVNTP FFKLSSLPSY YIPRDGPQAV YQEYINLLPA VEHPETFGQH PNADIASQIS
ETRTLFDTLI SLQPQVTSTA ATGAGPSRED KVLELSADVR QKIPADVDYE GTRKLLQDDP
SPINVVLLQE IQRYNTLLHT IRTSLTELEK GIKGLVVMSS SLEETFQCIH DARVPPLWEK
AYPSLKPLAS WTRDLCQRVE QFARWAETAR PPVLFWLSGF TFPTGFLTAV LQSSARQNNV
SVDTLSWEFT VSTVDDNNLL FPPKDGVFIR GLYLEGAGWD KKNSCLVEAE PMQLVCPMPT
THFRPVENRK KTAKGMYTCP CYYYPVRSGG AGRASFVVAV DLRSGAVPYD HWIKRGTALL
MSLDT
//
