ID A0A2D0RDH2_ICTPU Unreviewed; 512 AA.
AC A0A2D0RDH2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Mucolipin-3 isoform X1 {ECO:0000313|RefSeq:XP_017328587.1};
GN Name=mcoln3a {ECO:0000313|RefSeq:XP_017328587.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017328587.1};
RN [1] {ECO:0000313|RefSeq:XP_017328587.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017328587.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_017328587.1; XM_017473098.3.
DR AlphaFoldDB; A0A2D0RDH2; -.
DR STRING; 7998.ENSIPUP00000021110; -.
DR GeneID; 108268238; -.
DR KEGG; ipu:108268238; -.
DR CTD; 100334819; -.
DR OrthoDB; 2877219at2759; -.
DR Proteomes; UP000221080; Chromosome 7.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR CDD; cd21072; ELD_TRPML3; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR049134; MCLN_ECD.
DR InterPro; IPR047317; MCOLN3_ELD.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF23; MUCOLIPIN-3 ISOFORM X1; 1.
DR Pfam; PF21381; MCLN_ECD; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 253..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 66..239
FT /note="Mucolipin extracytosolic"
FT /evidence="ECO:0000259|Pfam:PF21381"
FT DOMAIN 337..477
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
SQ SEQUENCE 512 AA; 58972 MW; B6449BD7149C35A2 CRC64;
MASEWVVSGN NSEFELRRKL KYFFMNPCEK YRTRGRKPWK LTLQLIKITI ITIQFVWFGL
SNEMNVIFRG ENLTSFKHLF LKNYQERKGI YALYMKQEVH AHIDYIIMRY LTLRSVTVGN
HAFQRINGTD TPLILCQRFY TPENISPENQ TLSIDPNVQT ECVYIYSTKP FNITDFTLDF
KRLLSLEVRM KIKAINLQTV RHDELPDCYN FGVTVVFDNS AHSGRIKVSL HSGVQISVCA
HADISGSNAV SHFLLMVLLD LLVIMVCSLS LVLCTRSVIA GMRLLTEYAE FISVKWGKSL
SSLERMEFIN GWNILIIISD TLTVTASTLK ICILAKVLSN YTICSILLGT ATLLVWIGVL
RYLGFFQKYN ILILTMRAAL PSALRFSLCA VMIYLSYCFC GWIVLGPHHE NFRTFHTTAY
CLLSMINGDE VYSTFTKLRE RSALVWSFSR FYIYSFVSIF TYMVLSLFIA IITDTYDLIK
KQDGQVFSDL QKFMTEYRDA PAPETDTDAR AK
//
