ID   A0A2D0RDV6_ICTPU        Unreviewed;       691 AA.
AC   A0A2D0RDV6;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=E3 ubiquitin-protein ligase COP1 isoform X2 {ECO:0000313|RefSeq:XP_017328321.1};
GN   Name=cop1 {ECO:0000313|RefSeq:XP_017328321.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017328321.1};
RN   [1] {ECO:0000313|RefSeq:XP_017328321.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017328321.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_017328321.1; XM_017472832.3.
DR   AlphaFoldDB; A0A2D0RDV6; -.
DR   GeneID; 108268113; -.
DR   CTD; 64326; -.
DR   OrthoDB; 1126684at2759; -.
DR   Proteomes; UP000221080; Chromosome 7.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   CDD; cd16504; RING-HC_COP1; 1.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR042755; COP1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR44080; E3 UBIQUITIN-PROTEIN LIGASE COP1; 1.
DR   PANTHER; PTHR44080:SF1; E3 UBIQUITIN-PROTEIN LIGASE COP1; 1.
DR   Pfam; PF00400; WD40; 5.
DR   Pfam; PF13923; zf-C3HC4_2; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          94..132
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REPEAT          469..511
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          555..595
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          275..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          189..253
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        294..312
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   691 AA;  77633 MW;  DA484D9D6189585A CRC64;
     MSGCRQQQQP GAASGSVPGT SSASTATPII ASNGGSSANA NGSGISSRSL GSGSEAQLLG
     AQRPSLSGSN YSKKRPLYNG LINPYEDKSN DFVCPICFDM IEEAHMTKCG HSFCYKCIRR
     SLEDSNRCPK CNYIIDNVDQ LYPNFLVNEL ILKQKQRSEE KRLKRDHPNG TKWQFFQDVL
     GTDQEHLDLA NVNYMLELLV QKKKQLEAES QAAQRQILME FLKEARRNKR EQLEQLQKEL
     NYLEEDIKSV QDMSGLYSPV IDMDPNLDST VPQFGEAHSP APSSIIEPTE YIQPPQFGGS
     SQGKRQTSYN STLASRRKRL TAHFEDLEQC YFSNRMSRIT DDSRTVNQLD DFMECLSKFT
     RYNSVRPLAT LSYASDLYNG SSIVSSIEFD RDCDYFAIAG VTKKIKVFEY GTVIQDAVDI
     HYPVNEMTCN SKISCISWSS YHKNLLASSD YEGTVILWDG FTGQRSKVYQ EHEKRCWSVD
     FNLMDPKLLA SGSDDAKVKL WSTNLDNSVA SIEAKANVCC VKFSPTSRYH LAFGCADHCV
     HYYDLRNTKQ PIMVFKGHRK AVSYAKFVNG EEIVSASTDS QLKLWNVNKP HCLRSFKGHI
     NEKNFVGLAS NGDYVACGSE NNSLYLYYKG LSKTLLTFKF DTVKSVLDKD KKEDDTNEFV
     SAVCWRALPD GESNVLIAAN SQGTIKVLEL I
//