ID   A0A2D0RE07_ICTPU        Unreviewed;       924 AA.
AC   A0A2D0RE07;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Rho guanine nucleotide exchange factor 18a {ECO:0000313|RefSeq:XP_017328125.1, ECO:0000313|RefSeq:XP_017328126.1};
GN   Name=arhgef18a {ECO:0000313|RefSeq:XP_017328125.1,
GN   ECO:0000313|RefSeq:XP_017328126.1, ECO:0000313|RefSeq:XP_017328127.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017328125.1};
RN   [1] {ECO:0000313|RefSeq:XP_017328125.1, ECO:0000313|RefSeq:XP_017328126.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017328125.1,
RC   ECO:0000313|RefSeq:XP_017328126.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   RefSeq; XP_017328125.1; XM_017472636.3.
DR   RefSeq; XP_017328126.1; XM_017472637.3.
DR   RefSeq; XP_017328127.1; XM_017472638.3.
DR   STRING; 7998.ENSIPUP00000022083; -.
DR   Ensembl; ENSIPUT00000023031; ENSIPUP00000022083; ENSIPUG00000014965.
DR   Ensembl; ENSIPUT00000023062; ENSIPUP00000022112; ENSIPUG00000014965.
DR   GeneID; 108268008; -.
DR   KEGG; ipu:108268008; -.
DR   CTD; 407987; -.
DR   OMA; GLENNTH; -.
DR   OrthoDB; 2917157at2759; -.
DR   Proteomes; UP000221080; Chromosome 7.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041020; PH_16.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR13944; AGAP007712-PA; 1.
DR   PANTHER; PTHR13944:SF23; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 18; 1.
DR   Pfam; PF17838; PH_16; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   DOMAIN          65..262
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          301..404
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          765..791
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          894..924
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          633..734
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        902..917
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   924 AA;  107228 MW;  824A244D4E0898EE CRC64;
     MDESDQLRNK PILDELTADG ISIEDVQYLA LREELESDAR DFEAPTWSLT VDPQYVKNFS
     KDAVKRQDVI HELIQTEVNH VRTLKLMLFV YMRELRDSLL MDKSQLERLF PYLDRLLHEH
     QNFLQRLKHC RRESLEEGSD KNYCISNIGD ILITQFSEDC RSRLQDSYGV FCSHHTEAVN
     FYKEQLQNNK KFQNLIRRIG QLSIVRRLGV PEGILLITQR ITKYPVLVER IIKNTEEGTQ
     EHKDLVNAQE RIKDTISAVD TQVHQYEQLR EIAAQLEPKS YGTTSNGKIF RRDNLLQKDR
     RLLREGVLTW KPQNRSKSLD VILVLLPDLL LLLQDKDQKY VFAHLDGKPS VLPLQKLIVR
     DAAHSDKVMY LISASDVKAD LYEFHASTAE ERSSWRQQIW ETVEKCPHVE EELMENNDVY
     SDKLREAHDL LCEKDAQIEE ILRQKLQIFS NLSEVPMENP TTARRLLLQG SAPELQQGEL
     LINKAIIHAE ALQMQLMDGE MNFIPLSGES DVELRRKSLT LPAYNRMKRS ADGFRSRDQR
     PNSDPHLRDL YLEPLELSAD DEDCSTFPPP ACAFRAEWIE AADKLIRTLY SLKALVSQQD
     SELEVLRAVQ LEHERSSRQR YSSIQDQERQ RHLEKQREEL LHLQKVHTQQ RQEQEEWARE
     RQRHLLEMHR REQELSRRMD EYTNKEAWLC AERDVLHRSR EEYQQDLERL RDSTRIVEKE
     KEKLEQDIKR FRKHKNLTNL GGASHLGGAS HQDSAQLVVP YSSADDRLGR SPVQPSLPQE
     RPPVVPPRKE SMSVSASVKA DVPIQLLSTT NEALKSSSIQ QQIPTKLAIS SGKEKNKSKN
     IHHRNNSAAS IEVSEVFPIK VSGKETGSLR ATKTTNPHKL TADVYQELAV NSKLPHSADT
     RRRAAQPQNQ QRPAYSSQED VLFF
//