ID A0A2D0RE86_ICTPU Unreviewed; 432 AA.
AC A0A2D0RE86;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 2.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Caspase-2 isoform X3 {ECO:0000313|RefSeq:XP_017328838.2};
GN Name=casp2 {ECO:0000313|RefSeq:XP_017328838.2};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017328838.2};
RN [1] {ECO:0000313|RefSeq:XP_017328838.2}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017328838.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR RefSeq; XP_017328838.2; XM_017473349.3.
DR STRING; 7998.ENSIPUP00000012697; -.
DR KEGG; ipu:108268399; -.
DR OrthoDB; 2873736at2759; -.
DR Proteomes; UP000221080; Chromosome 1.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:UniProt.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00032; CASc; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 3.30.70.1470; Caspase-like; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR033139; Caspase_cys_AS.
DR InterPro; IPR016129; Caspase_his_AS.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR47901:SF7; CASPASE 2; 1.
DR PANTHER; PTHR47901; CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PIRSF; PIRSF038001; Caspase_ICE; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00114; CARD; 1.
DR SMART; SM00115; CASc; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS01122; CASPASE_CYS; 1.
DR PROSITE; PS01121; CASPASE_HIS; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 7..97
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 164..290
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 333..426
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
FT REGION 304..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..333
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 432 AA; 49063 MW; C2A96B8CF19463BE CRC64;
MLGGYGMKAQ DKLALKKNSV ALCKELVVDE LLIQYLQAED ILTESMAETI LAETTSQKKS
CRLLMLLPKR GPRAFSTFCA ALKETEQEHL YNLLLRFRDK ERFTDSKLPL PTEECAVPVK
RARTQESMEM CLDADSPLTT AVLPCTQEFY LSHCAQAYPM RSSPRGLALV LSNVHFEPEL
ELDTRRGGEV DEEVLRRLFT ELDFTVSLQK DLTLQAMQAC LEQFSRQPEH AVSDCCVVCL
LSHGVEGSIY GVDGKLLELD WVFERFDNAR CPLLQNKPKM FFIQACRGEE MDCGVDQLDG
DDAMQPTGCE QRDAGREENL DRQNRASEES ESLRVKLPQR SDMIYGFATL KGTAAMRNTK
KGSWFIQELN TAMRQRARDT HLSDILVQVN RQIKEREGHA PGSAHHRCKE MSEFTSSLCK
DLYLFPKYCA NN
//
