ID A0A2D0RFG3_ICTPU Unreviewed; 609 AA.
AC A0A2D0RFG3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Ferric-chelate reductase 1 isoform X1 {ECO:0000313|RefSeq:XP_017329282.1};
GN Name=frrs1b {ECO:0000313|RefSeq:XP_017329282.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017329282.1};
RN [1] {ECO:0000313|RefSeq:XP_017329282.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017329282.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FRRS1 family.
CC {ECO:0000256|ARBA:ARBA00009195}.
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DR RefSeq; XP_017329282.1; XM_017473793.3.
DR AlphaFoldDB; A0A2D0RFG3; -.
DR GeneID; 108268691; -.
DR KEGG; ipu:108268691; -.
DR CTD; 557898; -.
DR OrthoDB; 3027001at2759; -.
DR Proteomes; UP000221080; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08760; Cyt_b561_FRRS1_like; 1.
DR CDD; cd09628; DOMON_SDR_2_like; 1.
DR CDD; cd08544; Reeler; 1.
DR Gene3D; 1.20.120.1770; -; 1.
DR Gene3D; 2.60.40.4060; Reeler domain; 1.
DR InterPro; IPR006593; Cyt_b561/ferric_Rdtase_TM.
DR InterPro; IPR005018; DOMON_domain.
DR InterPro; IPR002861; Reeler_dom.
DR InterPro; IPR042307; Reeler_sf.
DR PANTHER; PTHR45828; CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE; 1.
DR PANTHER; PTHR45828:SF3; FERRIC-CHELATE REDUCTASE 1; 1.
DR Pfam; PF03188; Cytochrom_B561; 1.
DR Pfam; PF03351; DOMON; 1.
DR Pfam; PF02014; Reeler; 1.
DR SMART; SM00665; B561; 1.
DR SMART; SM00664; DoH; 1.
DR PROSITE; PS50939; CYTOCHROME_B561; 1.
DR PROSITE; PS50836; DOMON; 1.
DR PROSITE; PS51019; REELIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..609
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012700259"
FT TRANSMEM 380..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 513..532
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 586..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..191
FT /note="Reelin"
FT /evidence="ECO:0000259|PROSITE:PS51019"
FT DOMAIN 219..337
FT /note="DOMON"
FT /evidence="ECO:0000259|PROSITE:PS50836"
FT DOMAIN 341..548
FT /note="Cytochrome b561"
FT /evidence="ECO:0000259|PROSITE:PS50939"
FT REGION 176..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 67739 MW; E0427E49BC5A009F CRC64;
MLQISVKMKV LLFLFVVCIK SVDNYRNGKV KEACQDMMPD HHHHGPSPTS PPYTVTVDKS
IFSPGDQIKV TVSAVSSENN AYFEGFLIQA RDAANLDGGS VGTFTLLDSS ISQLLLCHHR
EGSAVSHTSD YHKTEVQVIW MAPQNPPPGV QFLVTVVRKF ELFWVKIPGP VLSLNGASPS
TPLSPQTTTA PTSLPRPFTS EHCGSTKTCL RDPEGCNPEN DTLCYFLSFR KVGQGVQFEL
SGPAAGYISF ALSTDKWMGN DDVYLCVSDT HSINITAAYV EGRTHPVTAS ENVLRETAWR
LADGVIQCSF YRNIHIPTSN QDRFNLDQMY YLFMAHGRAE NGRIHRHDRQ PLISAKQVVI
TGPPKDLIGS RAPLLIKFHA AFMLIGWMMT VSTGVIIARY FKPDWPETTV CGQRVWFQLH
RGLMLLTVLL TFIGFILPFV YRSGWSKRAG SHPYFGCTVM TLAVIQPIMA LFRPAPDSSR
RYIFNWVHLG TGTIAQVLAV VAIFLGIHQQ ALLLPASWTT GLLAGCVVWF VLADLALEMH
RRGIYPIGHF FRNFQVYTEN LQTEDKEGIL FVQSENESKG SSFKTVVLAV YLCGNLVFLA
LLLATISEV
//
