ID A0A2D0RGP4_ICTPU Unreviewed; 534 AA.
AC A0A2D0RGP4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=EH domain-containing protein 1a {ECO:0000313|RefSeq:XP_017329712.1};
GN Name=ehd1a {ECO:0000313|RefSeq:XP_017329712.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017329712.1};
RN [1] {ECO:0000313|RefSeq:XP_017329712.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017329712.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR RefSeq; XP_017329712.1; XM_017474223.2.
DR AlphaFoldDB; A0A2D0RGP4; -.
DR STRING; 7998.ENSIPUP00000003999; -.
DR Ensembl; ENSIPUT00000004191; ENSIPUP00000003999; ENSIPUG00000002819.
DR GeneID; 108268895; -.
DR KEGG; ipu:108268895; -.
DR CTD; 405810; -.
DR OMA; PADWESK; -.
DR OrthoDB; 12127at2759; -.
DR Proteomes; UP000221080; Chromosome 8.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0070293; P:renal absorption; IEA:Ensembl.
DR CDD; cd00052; EH; 1.
DR CDD; cd09913; EHD; 1.
DR Gene3D; 1.10.268.20; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR040990; DUF5600.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR031692; EHD_N.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11216; EH DOMAIN; 1.
DR PANTHER; PTHR11216:SF161; EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE CLONE 15, ISOFORM A; 1.
DR Pfam; PF18150; DUF5600; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF12763; EF-hand_4; 1.
DR Pfam; PF16880; EHD_N; 1.
DR SMART; SM00027; EH; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50031; EH; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 53..284
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 442..530
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 474..509
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 534 AA; 60322 MW; 811C071164FE5A19 CRC64;
MFSWSSRNGK KEPELFQNVS EGLKRLYRHK LFPLEDTYRF HDFHSPALED ADFDNKPMVL
LVGQYSTGKT TFIRHLMEQD FPGMRIGPEP TTDSFIAVMY GEQEGVIPGN ALVVDPKKPF
RKLNAFGNAF LNRFMCAQMK NPVLESISII DTPGILSGEK QRISRGYDFA AVLEWFAERV
DRIILLFDAH KLDISDEFSE VIKALKNHED KMRVVLNKAD QISTQQLMRV YGALMWSLGK
IINTPEVVRV YIGSFWAQPL HVPDNRKLFE AEEQDLFRDI QSLPRNAALR KLNDLIKRAR
LAKVHAYIIT SLKKEMPSVF GKDNKKKELI ANLGAIYEKI EREHNISPGD FPNLKKMQEL
LGGQDFAKFP ALKPKLLEAV EDMLANDIAK LMALVRQEEA AMPSQVVKGG AFDGTMNGPF
GHGYGEGAGE GIDELEWVVA RDKPSYDEIF YTLSPINGKV SGAAAKKEML KSKLPNTVLG
KIWSLADVDK DGFLDDEEFA LANHLIKVKL EGYELPAKLP THLVPPSKRG QEQQ
//
