ID   A0A2D0RI81_ICTPU        Unreviewed;       488 AA.
AC   A0A2D0RI81;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2023, sequence version 2.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=GRAM domain-containing protein 4 isoform X5 {ECO:0000313|RefSeq:XP_017330233.2};
GN   Name=gramd4b {ECO:0000313|RefSeq:XP_017330233.2};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017330233.2};
RN   [1] {ECO:0000313|RefSeq:XP_017330233.2}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017330233.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_017330233.2; XM_017474744.3.
DR   AlphaFoldDB; A0A2D0RI81; -.
DR   OrthoDB; 3028864at2759; -.
DR   Proteomes; UP000221080; Chromosome 8.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR   CDD; cd13221; PH-GRAM_GRAMDC4; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR004182; GRAM.
DR   InterPro; IPR037847; GRAMDC4.
DR   InterPro; IPR037845; GRAMDC4_PH-GRAM.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR37402; GRAM DOMAIN-CONTAINING PROTEIN 4; 1.
DR   PANTHER; PTHR37402:SF1; GRAM DOMAIN-CONTAINING PROTEIN 4; 1.
DR   Pfam; PF02893; GRAM; 1.
DR   SMART; SM00568; GRAM; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        118..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        145..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        230..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          349..429
FT                   /note="GRAM"
FT                   /evidence="ECO:0000259|SMART:SM00568"
FT   REGION          21..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   488 AA;  55855 MW;  187F61007E3BCC8B CRC64;
     MNIETLKQEL EKERLKRLDL EQKMNEILKT RPEDSPPPPS KAHGPAVNGT GEKQKESVSS
     KLWKWLYERF GVYMEDFRFQ PEENMVETEE PLSAKRLTEN MRRLKRGAKP VTNFMRNLSA
     LSSWHSVYTS AIAFILYMYA VWHGWAIPMF LFLAILRLSL NYLIAKGWRI QWSIVPEVSE
     PVEPPKEDLT VSEKFQLVLD VAQKAQNLFG KMSDVLEKIK NLFMWVQPEI TQKLYVGLWV
     AFIASGLLPY KLLGFIIGLY AGIKFFIIDF IFKSCPKLRD KYDTPYIVWK NLPTDPQLKE
     RQSGNISRRL SGFEKQIQPV VARGSLVAGV PCGVGRDEES GRAYSTKRGP FHEVFNLSEN
     ERPLPVCEHG WRCCLINRDR KMPTDYIRNG YLYVTENHLC FESSSSRSTS SKKNKVIKLQ
     DITDIQKYKV LSVLPGSGMG ISIATPSTQK PLVFGAMIHR DEAFEAIISQ YTKIIGATPP
     VTVTNPET
//