ID A0A2D0RJV2_ICTPU Unreviewed; 1116 AA.
AC A0A2D0RJV2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=WD repeat and HMG-box DNA-binding protein 1 isoform X1 {ECO:0000313|RefSeq:XP_017330802.1};
GN Name=wdhd1 {ECO:0000313|RefSeq:XP_017330802.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017330802.1};
RN [1] {ECO:0000313|RefSeq:XP_017330802.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017330802.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_017330802.1; XM_017475313.3.
DR AlphaFoldDB; A0A2D0RJV2; -.
DR GeneID; 108269436; -.
DR KEGG; ipu:108269436; -.
DR CTD; 11169; -.
DR OrthoDB; 3686044at2759; -.
DR Proteomes; UP000221080; Chromosome 9.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd21993; HMG-box_WDHD1; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR048591; Ctf4-like_C.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR022100; Mcl1_mid.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19932; WD REPEAT AND HMG-BOX DNA BINDING PROTEIN; 1.
DR PANTHER; PTHR19932:SF10; WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1; 1.
DR Pfam; PF20946; Ctf4_C; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12341; Mcl1_mid; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00398; HMG; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267,
KW ECO:0000313|RefSeq:XP_017330802.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 9..41
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 132..173
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1013..1067
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 1013..1067
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 308..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..1022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1056..1116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..388
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..860
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..879
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..949
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..983
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..1008
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1116 AA; 122218 MW; BB6F2631966670CE CRC64;
MPCERKPMRY GHSEGHTDVC FDEHGKCIVT CGSDGDVRIW ESLDDDDPKS INVGEKAYSV
ALRGGKLVTA VSNNTVQIHT FPDGDPDGIL TRFTTNANHV AFNSSGTRVA AGSSDFMIKV
IEVMDSSQQK TLRGHDAPVL SVAFDPSDEY IASSSCDGSV AVWSIEEQTQ VANWEVLPKS
SDVKNAKALC RLAWRGSGKL LAVPVDTTVQ LYERDSWTHV GTLSDDHLAQ QVVNVVVWSP
CGKFLAAGTV GGTLCVWDVD AKLCIERQKH EKGYTVCGMA WHPAGGQIAY TDTEGCLGLL
DGVCASSSSS SSSSSSATTK NITVSESKEQ NGYDDLFDED DGGLLDECRS VSAGDEDEDD
DLVPATRKPR NRGNVLDDDE NSRETGSVRL GRLAEDDGES GVFPAPAPPA AVAAAPRPVY
EGPVPTAPQR AFQPGSTPEH LMHRFMVWNS VGIVRSYNDE QDNAIDVEFH DTAVHHAMHL
TNTLEHSMAD LSQEAILLAC EGTDELASKL QCLHFSSWDT NKEWIADLPK GEDARALCLG
RGWVAAATSA MLVRLFSIGG VQREVFSLPG PVVCMAGHGE QLLIVYHRGT GFDGDQALGV
QLLQLGRKTK QVIHGEPLPL SRKSHLAWMG FSAEGTPCAV DSEGVVRMLN RSLGNTWTPV
CDTRESCKSR SDRYWVVGVH ENPQQLRCIP CKGSVFPPTL PRPAVAILPF KLPFCQTSTE
KGQMEEQYWR SVLFHNHFGF LSSSGYDTDE EGQRQQEKEQ QELLMKMFAL SCKLEREFRC
VELAEMMTQS VVTLAIRYAS RSRRMLLAQR LNELALEKAS QLQEEAETEE EAAYHSQAQN
TRFDRAGRVA RHSSSRAAQE DGDEEEQEDD DAQEEPTEAE EEPESKKSHV NPFSKGTKSP
EKPSIKPVSK EGRVNPFKVG GSGKPSSTSP SPQPRAINVL DTMTASNRKH TAAAKAPVLK
PLAPKPRSKT QATLLQMSTS KGASKKPQEK EMEKARAEKP EKPAEAPGDN VENSRPKTGF
QLWLEENRKS VLADDPDLEE MDIIKEAMSR FRALAGEERL KWTEKAKGSS GEGADLKKRK
RDEGGNNEVD ADENGAKKKK HSEASAKLSA FAFDKN
//
