ID   A0A2D0RKM4_ICTPU        Unreviewed;      1087 AA.
AC   A0A2D0RKM4;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Protocadherin-19 isoform X1 {ECO:0000313|RefSeq:XP_017330696.1};
GN   Name=pcdh19 {ECO:0000313|RefSeq:XP_017330696.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017330696.1};
RN   [1] {ECO:0000313|RefSeq:XP_017330696.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017330696.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_017330696.1; XM_017475207.3.
DR   AlphaFoldDB; A0A2D0RKM4; -.
DR   STRING; 7998.ENSIPUP00000025658; -.
DR   GeneID; 108269369; -.
DR   KEGG; ipu:108269369; -.
DR   CTD; 57526; -.
DR   OrthoDB; 4259465at2759; -.
DR   Proteomes; UP000221080; Chromosome 8.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 6.
DR   Gene3D; 2.60.40.60; Cadherins; 6.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   PANTHER; PTHR24028; CADHERIN-87A; 1.
DR   PANTHER; PTHR24028:SF40; PROTOCADHERIN-19; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; Cadherin-like; 5.
DR   PROSITE; PS00232; CADHERIN_1; 2.
DR   PROSITE; PS50268; CADHERIN_2; 6.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..1087
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012112943"
FT   TRANSMEM        672..696
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          26..125
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          126..234
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          235..342
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          346..449
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          450..558
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          564..657
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   REGION          852..876
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          970..1033
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1066..1087
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        856..876
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        972..986
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1018..1032
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1067..1087
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1087 AA;  119750 MW;  0C5803771B622CF1 CRC64;
     MDFVQVILCF MACWSGAGAV FNLKYTVEEE LRAGTKIANV TADAKVAGFA LGNRQPFLRV
     ISNSEPRWVN LSPAGLLLTK QKIDRDAVCR QMTKCTISLE VMSNSMEICV IKIEILDVND
     NAPRFPTSHI DIEISENAAP GTRFPLEGAS DPDSGSNGVQ TYSITPNDIF GLEIKTRGDG
     SKIAELIVEK TLDRETQSHY TFEITAEDGG EPPETGSVQL NIKVIDSNDN NPVFDEPVYT
     VNVMENAPIN TLVIDLNATD PDEGINGEVV YSFINFVSNL TKQMFKIDPK TGVISVNGIL
     DHEELRVHEI DVQAKDLGPN SIPAHCKVIV NVIDVNDNSP EIKLLSENSE MVDVSENAPL
     GYVIALVRVS DNDSGANGKV QCRLQGNVPF RLNEFESFST LLVDGRLDRE QRDMYNLTIL
     AEDSGYPPLR SSKSFAVKVT DENDNPPYFT KPHYQAMVLE NNVPGAFLLA VSARDPDLGM
     NGTVSYEIIK SEVRGMSVES YVTVNSNGEI YGVRAFNHED TRTFEFKVSA KDGGDPSLTS
     NATVRIVVLD VNDNTPVMTT PPLVNGTAEI SIPKNAGVGY LVTQIKADDY DEGENGRLTY
     SISEGDMAYF EIDQINGEVR TTKMFGENAK PSYQITVVAH DHGQTSLSAS AYIIIYLSPD
     LNTQEQIGSV NLSLIFIIAL GSIAAILFVT MIFVAVKCKR DNKEIRTYNC SFLYLRRVAE
     YSYGNQKKSS KKKKLSKNDI RLVPRDMEET DKMNVVSCSS LTSSLNYFDY HQQTLPLGGR
     RSESTFLNVE SQNSRNAAPN HGYHHTFTGQ GPQQPDLIIN GMPLPETENY SIDSSYVNSR
     AHLIKSTSTF KDMEGNSLKD SGHEESDQTD SEHDVQRGHY ADTAVNDVLN MTVPPNSCQL
     SDPDPSEGFH CQDECRILGH SDRCWMPRVP VPAHVKSPEH SRDVIALSIE ATGIDLPHYE
     DCGTTKRTFA TFGKDGPDEE PKGKRTNEMT TGICSPKANS GIREAGNGRE AISPITSPAH
     IKSPQSKPPT GYNSLKCCDV ERIANHSLLR QPEGKDSEPA LREINTLLQD GREKESPSSK
     RLKDIVL
//