ID   A0A2D0RKV2_ICTPU        Unreviewed;       320 AA.
AC   A0A2D0RKV2;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=L-serine ammonia-lyase {ECO:0000256|ARBA:ARBA00012093};
DE            EC=4.3.1.17 {ECO:0000256|ARBA:ARBA00012093};
DE   AltName: Full=L-serine deaminase {ECO:0000256|ARBA:ARBA00041766};
DE   AltName: Full=L-threonine dehydratase {ECO:0000256|ARBA:ARBA00042605};
GN   Name=sdsl {ECO:0000313|RefSeq:XP_017330771.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017330771.1};
RN   [1] {ECO:0000313|RefSeq:XP_017330771.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017330771.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:19169,
CC         ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:33384; EC=4.3.1.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00001161};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
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DR   RefSeq; XP_017330770.1; XM_017475281.1.
DR   RefSeq; XP_017330771.1; XM_017475282.3.
DR   AlphaFoldDB; A0A2D0RKV2; -.
DR   STRING; 7998.ENSIPUP00000016844; -.
DR   Ensembl; ENSIPUT00000017557; ENSIPUP00000016844; ENSIPUG00000011383.
DR   GeneID; 100528564; -.
DR   CTD; 113675; -.
DR   OMA; CQRAFEY; -.
DR   OrthoDB; 8406at2759; -.
DR   Proteomes; UP000221080; Chromosome 9.
DR   GO; GO:0003941; F:L-serine ammonia-lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   CDD; cd06448; L-Ser-dehyd; 1.
DR   Gene3D; 3.40.50.1100; -; 2.
DR   InterPro; IPR000634; Ser/Thr_deHydtase_PyrdxlP-BS.
DR   InterPro; IPR001926; TrpB-like_PALP.
DR   InterPro; IPR036052; TrpB-like_PALP_sf.
DR   PANTHER; PTHR48078:SF16; SERINE DEHYDRATASE-LIKE; 1.
DR   PANTHER; PTHR48078; THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF00291; PALP; 1.
DR   SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
DR   PROSITE; PS00165; DEHYDRATASE_SER_THR; 1.
PE   4: Predicted;
FT   DOMAIN          7..303
FT                   /note="Tryptophan synthase beta chain-like PALP"
FT                   /evidence="ECO:0000259|Pfam:PF00291"
SQ   SEQUENCE   320 AA;  33852 MW;  73484C0C27EC981C CRC64;
     MSDVQGFHIN SPLIESIGMS KRLGSPVYLK MESSQPSGSF KIRGIGHLIQ QVAGSKSNGV
     ICSSGGNAGL ATAYAARKLN IPATIIVPSS SPKLVLEKLQ DHGASVRVVG KVWDEANAEA
     VRLAESENLT LVPPFDHPLL WKGHSSLVHE LKAVLPCEPG AVVLCVGGGG LFCGVVQGLD
     EVGWGHVPIL CMETVGADCF NAAVKAGRLV TLPDITSEAK CLGAKTACSQ AFEYSKRPNV
     ISELVTDRQA LQALELFLDE ERVFVELACA ASLAAVYNGV IQRLQDEGRL RKPLGPLVVI
     VCGGSSINLA QLQHLRTVCK
//