ID A0A2D0RL04_ICTPU Unreviewed; 1450 AA.
AC A0A2D0RL04;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=ptprub {ECO:0000313|RefSeq:XP_017331194.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017331194.1};
RN [1] {ECO:0000313|RefSeq:XP_017331194.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017331194.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR RefSeq; XP_017331194.1; XM_017475705.3.
DR GeneID; 108269706; -.
DR CTD; 335096; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000221080; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF10; PROTEIN-TYROSINE-PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_017331194.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1450
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012180886"
FT TRANSMEM 747..772
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..185
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 187..272
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 285..380
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 383..486
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 492..593
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 914..1148
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1068..1139
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1180..1443
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1359..1434
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 835..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..855
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1450 AA; 163663 MW; 4BA4580BB275F0C3 CRC64;
MKACAIILIL VVHIHADSVE GPTAAGCTFD EDSDPSLCEF SQGEEDDFDW QLFRTHTLLH
STPDLLHGSY MIVNSSQHAA GQRAQLLLQT LSENDTHCVQ FSYFLYSRDG HSPGALRAYV
RVNGGPLGMA VWNISGSQGH QWYQVELAVS TFWPNEYQVL LEATVDRWGY IAVDNILLLN
YPCYKAPHFS RLGDVEVNAG QNATFQCVAA GRASEAEKFL LEQHNGKVSS GGSVKHLGRN
RFSVSFQLED VQRPEQDLYR CVTQSSRGSG VSNFAELIVK VPPSPIAPPQ LLRAGSTYLI
IQLNTNSILG DGPIIRREIE YRASHAPWSE INGVNMLTYK LWHLDPDTEY HISVLLTRPG
EGGTGPPGPP LISRTKCAEP MRALRDLRAS EIQARQLILQ WEPLAFNLTR CHTYSVSLCY
RYAIAGGTSG AGHNTTIREC LAVERNTSRF TLRDLPPYHS IHVRLALANT EGKKEGKEVM
FQTEEDIPGG IAPESLTFTP LDDMVFLKWE EPVEPNGIIT QYEISYQSIE SSDPGINVPG
PRRTVSKLRN ETYHMFSNLH PGTTYLISVR ARTAKGFGQT ALTEITTNIS APTFDYGDMP
SPLSETESTI TVLLRPAQGR GAPVSMYQVV VEEESGRKLK RELGMQECFP VPTSHGEAQA
RGAPHYYTAE LPPSSLAEGT PFTVGDNHTY NGYWNSPLDP RKNYLIYFQA MSNFRGETRI
NCIRIARKAA CKDLRRAMEV TQHSEEMGLI LGICAGGLVV LILLLGAIII IIKKGRDYYS
YSYYPRKPVN MNKTPITYRQ EKSHMMGSME RSFADQSTLQ EDERMALSFM DAHTCSTRSD
PRSSMNESSS LLGGSPRRHC GSKGSPYHTG QLHPAVRVAD LLQHINQMKT AEGYGFKQEY
ESFFEGWDVT KKKDKTKGRH DTLMDYDRHR VKLHPLLGDP NSDYINANYI DIRINREGYH
RSNHFIATQG PKQETVYDFW RMVWQENCFS IVMITKLVEV KCYKYWPDDT EMYGDIKISL
LKTETLAEYA VRTFSLERRG YSAKHEVQQF HFMSWPEHGV PYHATGLLAF IRRVKASTPA
DAGPVVVHCS MGAGRTGCYI VLDVMLDMAE CEGVVDIYNC VKTLCSRRIN MIQTEEQYIF
IHDAILEACL CGETAIPVNE FALTYKELLR VDSQSNSSQL REEFQTLNSV TPHLDVEECS
IALLPRNRER NRSMDVLPPD RALAFLVTTE GDSNNYINAA LTDSFHRPAA FIVTPHPLPG
TTTDFWRLVF DYGCTSIVML NQLNQSNSAW PCVQYWPEPG LQQYGPMQVE FLSMSADEDI
ITRLFRVTNV SRLQEGHLVV CQFQFLRWSA YRDVPDSKKA FLNLLAHVQK WQRECGDGRT
VVHCLNGGGR SGTFCACTIL MEMIQYQSMV DVFYAAKTLR NAKPNMVESL EQYRFCYDLV
MEYLECMDLR
//
