ID A0A2D0RMF3_ICTPU Unreviewed; 413 AA.
AC A0A2D0RMF3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Sphingomyelin synthase-related protein 1 {ECO:0000313|RefSeq:XP_017331325.1, ECO:0000313|RefSeq:XP_053538669.1};
GN Name=LOC108269803 {ECO:0000313|RefSeq:XP_017331325.1,
GN ECO:0000313|RefSeq:XP_053538669.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017331325.1};
RN [1] {ECO:0000313|RefSeq:XP_017331325.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017331325.1,
RC ECO:0000313|RefSeq:XP_053538669.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC {ECO:0000256|ARBA:ARBA00005441}.
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DR RefSeq; XP_017331325.1; XM_017475836.3.
DR RefSeq; XP_017331326.1; XM_017475837.1.
DR RefSeq; XP_017331327.1; XM_017475838.1.
DR RefSeq; XP_053538669.1; XM_053682694.1.
DR Ensembl; ENSIPUT00000006342; ENSIPUP00000006069; ENSIPUG00000004209.
DR GeneID; 108269803; -.
DR KEGG; ipu:108269803; -.
DR OMA; PRSWNLI; -.
DR OrthoDB; 1343173at2759; -.
DR Proteomes; UP000221080; Chromosome 9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups; IEA:InterPro.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd09515; SAM_SGMS1-like; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR045221; Sphingomyelin_synth-like.
DR InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR PANTHER; PTHR21290:SF25; SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1; 1.
DR PANTHER; PTHR21290; SPHINGOMYELIN SYNTHETASE; 1.
DR Pfam; PF14360; PAP2_C; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..76
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
SQ SEQUENCE 413 AA; 47541 MW; EFB2A38ACA2DDA13 CRC64;
MVTGDWVEGW SIKEVALWLR EHGFNDYVEL LCTKHRVDGA ALLCLTEHDL RSPPLQLPRL
GDIKRLALAL RGLQKQHAHP HTPLSDSGTN SVFLSHTSGS KSHLWNRSVD PSYPQYNGVG
MAMWEEHCHS YSNGKCKKDY GYLDPEGWKT VLSSVYVMLV FGITSFVMVL VHERVPDMRT
YPPLPDIFLD SVPRIPWAFS MAEACALVLC YILLLILLLH KYRSIIFRRF CSLTGTVFLL
RCVTMFVTSL SVPGHHLQCS GKMYGDISVK LLRALEIWSG FGMSLTGVHT CGDYMFSGHT
VVLTMLNFFV TEYTPRNWHI LHTLAWVLNL FGIFFILAAH EHYSIDVFIA FYITTRLFLY
YHTLANTRAY QHSRRARIWF PMFSFFECNI NGPIPNEYYW PFSRPAFMKT LIG
//
