ID A0A2D0RN08_ICTPU Unreviewed; 2751 AA.
AC A0A2D0RN08;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=MAX dimerization protein MGA a isoform X4 {ECO:0000313|RefSeq:XP_017331899.1};
GN Name=mgaa {ECO:0000313|RefSeq:XP_017331899.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017331899.1};
RN [1] {ECO:0000313|RefSeq:XP_017331899.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017331899.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR RefSeq; XP_017331899.1; XM_017476410.3.
DR GeneID; 108270087; -.
DR CTD; 569620; -.
DR OrthoDB; 5323209at2759; -.
DR Proteomes; UP000221080; Chromosome 9.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0009790; P:embryo development; IEA:UniProt.
DR GO; GO:0060429; P:epithelium development; IEA:UniProt.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20195; T-box_MGA-like; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR032060; MGA_dom.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267:SF32; MAX GENE-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF16059; MGA_dom; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 106..286
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT DOMAIN 2168..2218
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 347..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1101..1224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1451..1488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1814..1847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1913..1939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1951..1981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2000..2020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2045..2070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2149..2169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2285..2309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2334..2360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2492..2563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2718..2751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1129..1172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1180..1197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1204..1222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1454..1477
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1915..1939
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2149..2164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2492..2512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2513..2563
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2751 AA; 300616 MW; C0C2743DCE6D8EF9 CRC64;
MAIPHNQAIM VLRQEGTTTS TVPQTSACSL FVVVNQLHPA GGMQDKQTLF ASTEASPLAK
PTLGSCVASL NKVSSMSLSA MAATNTSNQL CNLPAESTCK GITVTLDNNN MWNEFFRCQT
EMILTKQGRR MFPCCRFRIS GLEPFQRYTL VMDMQPVDNY RYKWSDRRWE TNGKADPHIL
RSFVHPDSPA TGLDWMQNPV SFYKLKLTNN LLDREGHIII NSMHRYIPRL HVIPADKAMD
VIQLDGPDVV TFSFSQTEFF AVTAYQNLSI TQLKIDYNPF AKGFRDDANN SRCCKPKSAL
STEKMESEVK SNKEATALNN LKSLFAKMNA SEKVTTNLDL KTVHCDGPKR VEPESSSSSM
KRPWPGGLSE LIKGAHVKVK RISLEKIHNG SSQQMNIDGL VSKVNNMDVA SKDCTSENIS
IPDVTKEGME TVSFSKNSDS STLKNTTKSF SPTNLQCKLN KTTSNTPLNE KVATILSETE
TLTDEKLSNE ETSQCVVKPL DCGGEVKKKR AEPVPLPLLA LFLQQLKSKT RPTRPKPKSD
ACSVSSQSDK SCHDTSVAEN ISSTASFTPS LDTQLNVQPA VSPTSQTITT SILTCTVAST
EHESISTPNS AADAVTATTA SVVRDTLQLS THKKVSATTS AFVHNVKPNT SFSDTTHNTK
IVSVTLDDAS PGDAPSCDPK VFPATTPDAL SNELVHSNVT TDKSTTEPAH DSCTIPCPEA
VPWSPSPGVK TQSSPSCAPS SPYMSAPSSP DPFPPSMFCD RPIPPRKTLD PFPPCLSLDR
PRPLLELVDP LPQIFFTRPT PPEDPGPAVL SITSEVNCPV VSPDPNIPKE LKPSLKTSKG
TKRKVKQKKS GKSKLSEDAE VKEVPIPVPM QPNLEDVDGQ LFVSFMSKKA LEIHLGDEAK
EDIVEKTTEN IEDEVHDEEE RINALEKVLL RDLTNMKNRQ VIHPVLQAVG LKLNLLDVTL
SIDLQYLGVC LPIPPPIHLP EGSSGTCSSQ VHFVSRTGKT TDITKIKGWR EKFSTSSSSV
PRVTTSSDTG QKNLSAFCSD MLDEYLESEG KLIDERAASF SQAVVTPVAY QLPTKSTSYV
RTLDSVLKKQ ALPLACALSE PSATSRKTML NSKRNKAVSE VKTKKPMKVE NPVSSTDKKS
GGTSSKKSTK SNASKSGSSV QSAASALSQS KKSSKVKTKK GSKPSQDSFH TAEKPAKDLK
SAVPAGQNAS SSPGSNLPVG RSSGLPKTLV KLRDVEDGAV WEGKHRTYIT MERAAIALSC
LVTAEGTIRG SSSTVIKRRA PPCLNDFCRL GCVCASLVQE RRQHHCGKPQ CMLGCDCLRR
KVVLLKNEDI YEESAPVNDT EENATKVKKK KNRVSYILSG TDAAPEPALH VKTLWVQQND
SDSEQLFIPD PARPLHPHPQ SLDLQKDLEK FLHSSPKRAA VRAVDGEGLI RVKNQESLDC
ARVRPFCGRK LSPGRQRRMK EGHPDHGSQD SLQEMEEGEL RPPTMSGPTK RLEIVSKCKW
ATEDRRNVVL RTVCERMAQD RLKHPFWIGK YQIQPTSKTI KETDEGSIIT YKVVISQPQV
EESEEKKEQK RIKQLEAQLI ETIGKSEVKG LPLLSQVTPA GLLKAEKKPS GALGQIMVNG
KLYPQAKLEL GQMGALHPAN RLAAYITGRV CVANKHVPKA VTTATKTYHT ASTTPTSVAT
TTVTSTLSSA VTLDKPTVSI NMRPKASIAS HASPASGTTD GSIQGVKAVS GSAASEKSFV
LSTTGSNVAR SGSGIRLMQP QTSTCPAVPG QRIVMFKAAN PAGRVVHFVP LGQFRALSPN
IVVRPQQATL IRLPTHNPVP LSKSQTSTTA ASSTAPSSAT HDQHMAPVQS ITRDTITTSS
TSPITTKPVT SLSGSKTLLF CNKPSTVKII PGFLRDTATS TLRILPMKAV ETKTVKDPGN
TSSASSAQSS SEGHPENQGL QLTSQSFLTP KNQESQKLDN SIHTSPTPTK ESCDEDSQCS
KMSPENVIFT DHSYTFEMKK TSTPSKKTVD VSKDSSDPAN SSTYHMLLKE VLDLGPVEVE
SCGTSGAVLG SESGVESKAE SHLMEEDVNS DCTELTEDSD MYIDSDSCQS SDQEDVCVVS
DSDREEKNKK KQEFIDAHVQ NLTEMDDDEL VDIETFEEGA EKISALSEQM QHDSFQNQSS
DKETNENLFK LRKRKDEKRR RITLRNCFQN LKQALNIEDP KVPKITLLSE ALEEINRLTK
RGDHLVKMWD KLRKKRAYYI EMASQLSGKN KASISQKLDE IIAKQKSLEI EDKGNDTSLN
LKKRVPKHSH RNINAKQKKT GTKDKAKHLS ISKEKHLGFK GRRTENISTN QKMTVAKPTD
TRPTPQLGKC PLPSPILRDR TRPNILSRSN SQTLANDQVL VPQVIPLVEA VVPCNQIITI
SNPLQPIDIT SLGERQSTTP GVATVSISLP PISQPLCVEN PPPMLEPQVL KLTNSLVTTP
VVDISLPKFS SIVSLVQSEK LLVTPPSAAD TQTQAACNST AGEAQQNPSS YEPTLEEEKH
LDKQLPEVVP KKPEHDAKVT IEEDPKKQNE DEKNTPKPEQ EDDRLMSLLD ELDFLSQTSE
LQEAASSLTE EDVLTDLLTN KEVDMDRDDE RSLSPLFLKL DEDLVSPTSK DEEIEDIPPK
VDDLVKVIFG SESPPNSSES EIFSAAGDDC TRVSAYHVKN DAPTPPPLLQ MKTGGCTTAD
SLKEQANLSW RPMPKLAPLG LKTQETGHPK LISPHAPKSD SKLPSLHNTH V
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