ID   A0A2D0RN96_ICTPU        Unreviewed;       862 AA.
AC   A0A2D0RN96;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2023, sequence version 3.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Echinoderm microtubule-associated protein-like 1 isoform X1 {ECO:0000313|RefSeq:XP_017331984.3};
GN   Name=eml1 {ECO:0000313|RefSeq:XP_017331984.3};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017331984.3};
RN   [1] {ECO:0000313|RefSeq:XP_017331984.3}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017331984.3};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC       microtubules are slightly longer, but more dynamic.
CC       {ECO:0000256|ARBA:ARBA00003210}.
CC   -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC       {ECO:0000256|ARBA:ARBA00006489}.
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DR   RefSeq; XP_017331984.1; XM_017476495.1.
DR   RefSeq; XP_017331984.3; XM_017476495.3.
DR   AlphaFoldDB; A0A2D0RN96; -.
DR   GeneID; 108270132; -.
DR   KEGG; ipu:108270132; -.
DR   CTD; 2009; -.
DR   OrthoDB; 2959353at2759; -.
DR   Proteomes; UP000221080; Chromosome 9.
DR   CDD; cd21947; TD_EMAP1; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR024977; Apc4-like_WD40_dom.
DR   InterPro; IPR005108; HELP.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR13720:SF22; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 1; 1.
DR   PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF03451; HELP; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 11.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   DOMAIN          236..307
FT                   /note="HELP"
FT                   /evidence="ECO:0000259|Pfam:PF03451"
FT   REPEAT          586..627
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          641..729
FT                   /note="Anaphase-promoting complex subunit 4-like WD40"
FT                   /evidence="ECO:0000259|Pfam:PF12894"
FT   REPEAT          715..746
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          827..862
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          134..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          54..81
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        136..180
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        192..208
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   862 AA;  94883 MW;  594866C95FF9A8E5 CRC64;
     MVSTVSVLSV CFAAGILHRR LANKQPACEK FPLLCMMSDP EGLAVDDSAS ATSSMEVSDR
     LASLEQRVQM QEDEIQLLKS ALADVVRRLN ISEEQQAFLS RKGPTKARPM IATLPLKPTV
     HNGNVLPKKI ATLLSPSGSK KDNNTPATKS VSSLSSPFKF PLRPSYSTVK RTSSSEHVGP
     SSRKEGGGDA KSNRNRTASI GNNSSGKKAS ESKQREPVFS AGMRRVTHCK DEGYVKMYLK
     GRPITMYMPK ELVDTYCLEA KSDVPPKKLK LDWVYGYRGR DCRSNLYLLP TGETVYFIAS
     VVVLYNVDEQ LQRHYTGHTD DIKCLAVHPD KITIATGQVA GTSLDGKQLA PHVRVWDSVS
     LNTLHVIGTG FFDRALVCLS FSKSNGGSWL CVVDDSNDHV LSVWDWQREE RLAEVKCSNE
     SVFAADFHPT DANIILTCGK SHLCFWSLEK GSLLKKQGLF EKQEKPKFVL CVTFSENGDA
     ITGDSSGNIL VWGKGSNRIS LAIQGAHESS VFALCILRDG TLVSGGKDRK LTSWDGNYQK
     INMVEVPEMY GPIRTVAEGK GETILIGTTK NYILMGNLNG EFTPITQGHT DELWGLAVHP
     LKLQFLTCGH DKLVSLWDSE SHQPLWTKTL EDAAQSAGFH PSGAIVAIGT QTGRWLVLDT
     ETKDLVTVHT DGNEQLSVMR FAPDGNFLAI GSHDNYIYIY AVAENGKKYS RVGKCSGHSS
     FITHLDWSVD SQYLVSNSGD YEILYWIPSV CKQVVSVETT RDIPWATFTC TLGFHVFGLW
     PDGSDGTDIN AVCSSNEKRL LATGDDFGKV HLFSFPCSQS RTPSHVYGGH SSHVTNVNFL
     FDDSHLMSTG GKDMSVMQWR VI
//