ID A0A2D0RNZ6_ICTPU Unreviewed; 807 AA.
AC A0A2D0RNZ6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Gephyrin isoform X3 {ECO:0000313|RefSeq:XP_017332228.1};
GN Name=LOC108270253 {ECO:0000313|RefSeq:XP_017332228.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017332228.1};
RN [1] {ECO:0000313|RefSeq:XP_017332228.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017332228.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005046}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the MoeA family.
CC {ECO:0000256|ARBA:ARBA00008339}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the MoaB/Mog family.
CC {ECO:0000256|ARBA:ARBA00007589}.
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DR RefSeq; XP_017332228.1; XM_017476739.3.
DR AlphaFoldDB; A0A2D0RNZ6; -.
DR Ensembl; ENSIPUT00000020536; ENSIPUP00000019684; ENSIPUG00000013063.
DR GeneID; 108270253; -.
DR OrthoDB; 275356at2759; -.
DR UniPathway; UPA00344; -.
DR Proteomes; UP000221080; Chromosome 9.
DR GO; GO:0061598; F:molybdopterin adenylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0061599; F:molybdopterin molybdotransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00887; MoeA; 1.
DR CDD; cd00886; MogA_MoaB; 1.
DR Gene3D; 3.40.980.10; MoaB/Mog-like domain; 2.
DR Gene3D; 2.40.340.10; MoeA, C-terminal, domain IV; 1.
DR Gene3D; 3.90.105.10; Molybdopterin biosynthesis moea protein, domain 2; 1.
DR Gene3D; 2.170.190.11; Molybdopterin biosynthesis moea protein, domain 3; 1.
DR InterPro; IPR036425; MoaB/Mog-like_dom_sf.
DR InterPro; IPR001453; MoaB/Mog_dom.
DR InterPro; IPR008284; MoCF_biosynth_CS.
DR InterPro; IPR038987; MoeA-like.
DR InterPro; IPR005111; MoeA_C_domain_IV.
DR InterPro; IPR036688; MoeA_C_domain_IV_sf.
DR InterPro; IPR005110; MoeA_linker/N.
DR InterPro; IPR036135; MoeA_linker/N_sf.
DR NCBIfam; TIGR00177; molyb_syn; 2.
DR PANTHER; PTHR10192:SF5; GEPHYRIN; 1.
DR PANTHER; PTHR10192; MOLYBDOPTERIN BIOSYNTHESIS PROTEIN; 1.
DR Pfam; PF00994; MoCF_biosynth; 2.
DR Pfam; PF03454; MoeA_C; 1.
DR Pfam; PF03453; MoeA_N; 1.
DR SMART; SM00852; MoCF_biosynth; 2.
DR SUPFAM; SSF63867; MoeA C-terminal domain-like; 1.
DR SUPFAM; SSF63882; MoeA N-terminal region -like; 1.
DR SUPFAM; SSF53218; Molybdenum cofactor biosynthesis proteins; 2.
DR PROSITE; PS01078; MOCF_BIOSYNTHESIS_1; 1.
DR PROSITE; PS01079; MOCF_BIOSYNTHESIS_2; 1.
PE 3: Inferred from homology;
KW Molybdenum cofactor biosynthesis {ECO:0000256|ARBA:ARBA00023150}.
FT DOMAIN 18..165
FT /note="MoaB/Mog"
FT /evidence="ECO:0000259|SMART:SM00852"
FT DOMAIN 539..716
FT /note="MoaB/Mog"
FT /evidence="ECO:0000259|SMART:SM00852"
FT REGION 183..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..199
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 807 AA; 87388 MW; 95A4E1A49113BA81 CRC64;
MASDGMSLTN HDHQIRVGIL TVSDSCFRNL ADDRSGFNLK DLVHDPSLLG GIVSAYKIVP
DERDFIKETL VDWCDEKELN LILTTGGTGF APRDVTPEAT REVIEREAPG MALAMLMGSL
NVTPLGMLSR PVCGIRGKTL IINLPGSKKG SQECFQFILP ALPHAIDLLR DAIVKVKEVH
NALEDLPSPP PPLSPPPVTS PHKQTEDKGI QCEEEEEEKK DSGVASTEDS GSSHITAAAI
AAKSVFHPTH AVVMAKGGQP LTCFVPPTTL PSHFTCSCGD QIPDAIISRG VQVLPRDTAS
LSTTPSESPR AQQSRLSTAS CPTPKVQSRC GSKENILRSS HSAVDITKVA QRHRMSPFPL
TSMDKAFITV LEMTPVLGTE IINYRDGMGR VLAQDVYAKD NLPPFPASVK DGYAVRAADG
PGDRFLIGES QAGEQPTRTV MPGQVMRVTT GAPIPCGADA VVQVEDTELL QESEDGTEEL
EVRILVQARP GQDIRPIGHD LKRGECVLAK GTHMGPSEIG LLATVGITEV EVHKFPVVAV
MSTGNELLNP EDDLHPGKIR DSNRSTLLAT IQEHGYPTIN LGIVGDNPDD LLNALNEGIS
HADVIITSGG VSMGEKDYLK QVLDIDLHAQ IHFGRVFMKP GLPTTFATLD LDGARKLIFA
LPGNFSYRDT GVTLLEAMPM SDSEASRLPV SPPPRRSNPV SAVVTCNLFV IPALRKMQGI
LDPRPTIIKA RLSCDVKLDP RPEYHRCILT WHHQEPLPWA QSTGNQMSSR LMSMRSANGL
LMLPPKTEQY VELHKGEVVD VMVIGRL
//
