ID A0A2D0RP31_ICTPU Unreviewed; 1159 AA.
AC A0A2D0RP31;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Papilin isoform X2 {ECO:0000313|RefSeq:XP_017331710.1};
GN Name=paplna {ECO:0000313|RefSeq:XP_017331710.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017331710.1};
RN [1] {ECO:0000313|RefSeq:XP_017331710.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017331710.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_017331710.1; XM_017476221.3.
DR AlphaFoldDB; A0A2D0RP31; -.
DR STRING; 7998.ENSIPUP00000013372; -.
DR Ensembl; ENSIPUT00000014029; ENSIPUP00000013465; ENSIPUG00000009136.
DR GeneID; 108269998; -.
DR CTD; 562930; -.
DR OMA; KLDSGWF; -.
DR OrthoDB; 2910701at2759; -.
DR Proteomes; UP000221080; Chromosome 9.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR CDD; cd22635; Kunitz_papilin; 1.
DR Gene3D; 2.60.120.830; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR InterPro; IPR045371; ADAMTS_CR_3.
DR InterPro; IPR010294; ADAMTS_spacer1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR010909; PLAC.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR PANTHER; PTHR13723:SF317; PAPILIN ISOFORM X1; 1.
DR Pfam; PF19236; ADAMTS_CR_3; 1.
DR Pfam; PF05986; ADAMTS_spacer1; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF08686; PLAC; 1.
DR Pfam; PF19030; TSP1_ADAMTS; 4.
DR Pfam; PF00090; TSP_1; 1.
DR PRINTS; PR01857; ADAMTSFAMILY.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00406; IGv; 2.
DR SMART; SM00131; KU; 1.
DR SMART; SM00209; TSP1; 5.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS50092; TSP1; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR613273-3}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1159
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012655118"
FT DOMAIN 703..753
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 807..900
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 919..1011
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1014..1099
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1110..1149
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
FT DISULFID 36..72
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 40..77
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 51..62
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
SQ SEQUENCE 1159 AA; 127673 MW; 7E320D7E58D17BD2 CRC64;
MMKLLLAVAS VQMFLAPVFM MPSADYWGEW GPYGECSRSC GIGVTVRTRQ CVSQRTDGGH
SCVGPDKSYR TCNIQDCPES SRDFREEQCS QFDGTDFHGK HYKWLPYYGE NQCELNCIPK
GENFYFRHRS LVVDGTPCHP GSNNICVEGV CTRLGCDSML DSGQQEDACL QCGGNGQSCH
LVRNTFSMRG LPKGYNQMFI IPVGATSIRI TESVPTRNYL AIKNLRGEYY LNGHWVIEFS
RSTPIAGSML YYQRGTEGEM SPETITGRGP TTEPLVIELI TQEANQGIEY EYYLPNSHPR
EGHYWSYGSW SVCSKGCGSG YQSRLVFCTF DNEAYPDYLC ASLPRPLNNR TCNEQQCPLT
RRMAYVYPPQ IWTPKEARHV YVQVYSWKVG EWNQCSVTCG GGTQVRRVEC ISHDVSGRRL
VEDSLCEAYA PKPVSQQTCN MQHCAQYSMS SWSQCSVTCG SGDQTREVMC VGSAGGSRVA
DYMCASLPKP PSTQTCEMPA CVTRIGWHIG DWGLCSKSCS SGLRERQVIC SDSQRNIYGV
EHCNTYAKPS TVESCNTQPC YSPQVVPSMQ DTRGYDNTIF GFYPYNPADT TTVHQRDVPY
CHQTAFGCCQ DGVSAASGPH GQGCYQTSSC SHTRYGCCQD GVTHAQGPNK EGCPEYVPSV
PASEHEVCSR ATYGCCFDGV TAARGTNGEG CPVPHGRAQR APCDLPHSAG LCDEWTARYY
YDPAKSRCVH FWYGGCHGNS NNFATMEECE QTCQSHRPVS TSYSSTWSQI WPDANTSQHS
HRRWIESVVR RPATRDVQAS SPNKSWPAVG VSIDKSDPST VEGIVGRSVV LPCKVNPPPS
STVTVEWRKD GVLLDPSRYR QQPNGSILMG PVRIKDSGWL LCVATRDRER DHRYIYLSVS
EPKDGADRPD SAGSIIVSPR FSIDRSDSSL VNARAGQSAR LHCTILPSSA ANSVIVQWTK
NGAVLNTLRH SQHSDGTLVI NSLTSDDSGV YTCTASSTQQ LEQLQIQLRV SGDLRITTAP
SNMEVSQGSV VRLPCVASGE NVNIAWSRNG VPVRPDGHRV QVAADGTLTL YNVQPVDEGS
YTCSAYAGTH AVSATAEIRV TKEYDRGQSL SPDCVDEPEL ANCLLIVSAR LCGHKYYSSF
CCASCYNYSI GKSRPGRHG
//
