ID   A0A2D0RQX1_ICTPU        Unreviewed;      1016 AA.
AC   A0A2D0RQX1;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 {ECO:0000313|RefSeq:XP_017332890.1};
GN   Name=hcn2b {ECO:0000313|RefSeq:XP_017332890.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017332890.1};
RN   [1] {ECO:0000313|RefSeq:XP_017332890.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017332890.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the potassium channel HCN family.
CC       {ECO:0000256|ARBA:ARBA00006305}.
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DR   RefSeq; XP_017332890.1; XM_017477401.3.
DR   RefSeq; XP_017332891.1; XM_017477402.1.
DR   RefSeq; XP_017332892.1; XM_017477403.1.
DR   RefSeq; XP_017332894.1; XM_017477405.1.
DR   AlphaFoldDB; A0A2D0RQX1; -.
DR   GeneID; 108270575; -.
DR   KEGG; ipu:108270575; -.
DR   CTD; 557285; -.
DR   OrthoDB; 74296at2759; -.
DR   Proteomes; UP000221080; Chromosome 10.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013621; Ion_trans_N.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR   PANTHER; PTHR45689:SF11; POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 2; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08412; Ion_trans_N; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   3: Inferred from homology;
KW   cAMP {ECO:0000256|ARBA:ARBA00023149};
KW   cAMP-binding {ECO:0000256|ARBA:ARBA00022566};
KW   Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022566};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022461}.
SQ   SEQUENCE   1016 AA;  113169 MW;  7E1331D0D321027A CRC64;
     MDEAEDGDED RRREGGPRLD SGGYAHLDPS RTRCLTPGGG AAPSQTSNSS ASGPNELRAS
     RDTDRAPVSL CQGDACGFGF GFSFTSNDDD TGTSATSVDV EQEDGGEEEE EEEEEDVGMR
     RAVNGDCRRG TSSPSLLSKQ EKQTGGSVTP EERRAGSACP SATMDGSITP AGTGAAEPEK
     KDSRVAFSSS TPAQPAALSK TEDGQLTAED AEARDSQTYM QRQFSSMLQP GVNKFSLRMF
     GSQKAVEKEQ ERVKSAGNWI IHPYSDFRFY WDFTMLMFMV GNLIIIPVGI TFFKDETTTP
     WIIFNVVSDT FFLMDLVLNF RTGIVFEDNT EIILDPKKIK QKYLRTWFVV DFISSIPVDY
     IFLIVEKGID SEVYKTARAL RIVRFTKILS LLRLLRLSRL IRYIHQWEEI FHMTYDLASA
     VMRIINLIAM MLLLCHWDGC LQFLVPMLQD FPSDCWVSLN KMVNDSWSEL YSFALFKAMS
     HMLCIGYGRQ APESMSDIWL TMLSMIVGAT CYAMFIGHAT ALIQSLDSSR RQYQEKYKQV
     EQYMSFHKLP ADFRQKIHDY YEHRYQGKMF DEESILEELN EPLREEIVNF NCRKLVASMP
     LFANADPNFV TAMLTKLRFE VFQPGDYIIR EGTIGKKMYF IQHGVVSILT KGNIGMKLSD
     GSYFGEICLL TRGRRTASVR ADTYCRLFSL SVDNFNEVLE EYPMMRRAFE TVAIDRLDRI
     GKKNSILMHK VQHDLNSGVF NNHENELIQE IVKYDREMVK LVDLQRPRAM SATQSTYGTM
     FPSSNQPPTG SAIATLQQAV AMSFCPQMAN PLAAHGALQS PRMVRRFQVV QSLSSPGTQQ
     TPPGSQFPST ALPSALTSTP VQSPLATGSR TFQYSSSPMG APSGSQLSLV QQHISSPTHR
     ATVPRSAMTE DARALSASQP SLPHDATQPA APSPPQSTRV SSTSIGPPHS LPGPMAFRAA
     IPPRMTLQHQ MSVGAFPPAS LPQMRPSQDS GLPKKDSVVS LPDTDHHVRS RLSSNL
//