ID A0A2D0RSG4_ICTPU Unreviewed; 1948 AA.
AC A0A2D0RSG4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Echinoderm microtubule-associated protein-like 6 isoform X2 {ECO:0000313|RefSeq:XP_017333444.1};
GN Name=eml6 {ECO:0000313|RefSeq:XP_017333444.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017333444.1};
RN [1] {ECO:0000313|RefSeq:XP_017333444.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017333444.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic.
CC {ECO:0000256|ARBA:ARBA00003210}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR RefSeq; XP_017333444.1; XM_017477955.3.
DR Ensembl; ENSIPUT00000019344; ENSIPUP00000018556; ENSIPUG00000012473.
DR GeneID; 108270928; -.
DR CTD; 400954; -.
DR OrthoDB; 2959353at2759; -.
DR Proteomes; UP000221080; Chromosome 10.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 6.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF52; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 6; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF03451; HELP; 3.
DR Pfam; PF00400; WD40; 12.
DR SMART; SM00320; WD40; 28.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 4..48
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 250..265
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 330..362
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 404..435
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 558..590
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 661..708
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 1224..1256
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1331..1391
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 1680..1714
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1725..1798
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 1913..1948
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1264..1288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1948 AA; 216024 MW; 7884526A12E19962 CRC64;
MADKTAPRCQ LRLEWVHGYR GHQCRNNLYY TAGKEIVYFV AGVGVVYNTR EHTQKFYLGH
NDDIISLALH PDKIQVATGQ VGKDPYICVW DSYTLTTVSI LRDVHTHGVA CLAFDADGQR
LVSVGLDAKN TVCVWDWKKG RVLATATGHS DRIFDISWDP FLAHRLVSCG VKHIKFWTLC
GNALTPKRGI FGKTGDLQTI LCLATAKDEV TYSGALNGDI YVWKGLNLVR TVQAAHGAGI
FSMHSCEEGF ATGGRDGCVR LWDVDFKPIT KIDLREAEQG YKGLSIRSVC WKADRILAGT
QDSEIFEVMV RDRDKPLLVM QGHSEGELWA LDLHPKQPIA VTGSDDRSVR LWSLADHTLI
ARCNMEEAVR SVCFNNDGSQ LALGMKDGSF TVLRVRDMTE VVHIKDRKEV IHELKFSPDG
SYLAVGSNDG LVDIYAVAQR YKKVGECNKS SCFITHLDWS VDSRFLQTND GAGERLFYRM
PAGKFLPKEE AKGIHWMTWT SVLGPEVNGI WPKYSNVNDI NSVDANYSNA VLATGDDFGL
VKLFRFPCLK KAAKFKKYIG HSAHVTNVRW SHDLQWVVST GGADHSVFQW RFLPEGVMNG
VLEPLLQEGY ADSNSGDSDS DLSDVPELDS DIEQEAQMNY ERQVYKEDLP QLKKKLVGSL
KRQKAPDEGL RLQFVHGYRG CDCRNNLFYT QAGEVVYHVA AVAVVYNRQQ HSQRFYLGHD
DDILSITAHP LKDYVATGQV GRDPAIHVWD VQTLKCLSLL RGQHQRGVCA LEFTADGKSL
VSVGIDEGHC IVIWDWKKGE KLAKGKGHKD KIFVVKGNPF RMDKLVTVGV KHIKFWQHTG
GGLTFRRGIF GNLGKQETMM SACYGRSEDL VFSGATTGDV YIWKDTTLIK TLKAHDGPVF
AMCSLDKGFV TGGKDGIVEL WDDMFERCLK TYAIKRAALS PSSKGLLLED NPSIRAITLG
HGHILVGTKN GEILEIDKSG PMTLLVQGHM EGEVWGLAAH PLLPICATVS EDKTLRIWEL
SANHRMVAVR KLKKGGRCCA FSPDGKALAV GLNDGSFLVV NADTLEDMVT FHHRKEIISD
LKFSQDAGKY LAVASHDSFV DIYNVLTSKR VGICKGATSY ITHIDWDTRG KLLQVNTGAK
EQLFFEAPRG RRQNISTAEF EKVEWATWTS VLGATCDGIW PTLSFVNASS LTKDRKLLAT
GDDFGFIKLF SFPCKGQFAK FKKYVGHSAN VTNVRWSNDD TTLLSVGGAD TALMIWAREG
IGPRESKAVD SEESDDDAEE DGGYDSDVAR EKNMDYTTKI YAISIREMTG VKPHQQQKEI
LVDERPPVSR AAPLPEKLQK NNITKKKKVV EELALDHVFG YRGFDCRNNL HYLNDGADIV
FHTAAAAVIQ NLSAGTQSFY LEHTDDILCL TVNQHPKYQN VIATGQIGLA PSIHVWDAMS
KQTLSVLRCS HAKGVGYVNF SATGKLLLSL GVDPEHTITV WRWQEGTKVS SKAGHSDRIF
VVEFRPDSDT QFVSVGIKHI KFWTLVGGSL LYKKGVIGVV EEGRMQTMLS VAFGANNLTF
TGAINGDVYV WRDHFLVRVV AKAHTGPVFT MYTTLRDGLI VTGGKERPTK EGGAVKLWDQ
EMKRCRAFQL ETGLPVESVR SVCRGKGKIL VGTKDGEIIE VGEKNAASNT LINGHTQGRI
WGLATHPCKD LFISASDDGT IRIWDLADKK LLNKVSLGHP AKCTAFSPNG EMVSIGMENG
EFIVLLVNAL TVWGKKRDRS VAIQDIRFSP DNRLLAVGSV ESAVDFYDLT LGPALNRIGY
CKDIPGFVIQ LDFSADSKFI AVSTGSYKRQ VHEVPSGKIV TEQAIADRIT WATWTSVLGD
EVLGVWPRNA DKADVNCASV SHAGLNVVTG DDFGLVKLFD FPCSEKFAKH KRYFGHSAHV
TNIRFSYDDK YVISVGGNDC SVFVWRCL
//