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Database: UniProt
Entry: A0A2D0RSM9_ICTPU
LinkDB: A0A2D0RSM9_ICTPU
Original site: A0A2D0RSM9_ICTPU 
ID   A0A2D0RSM9_ICTPU        Unreviewed;      2496 AA.
AC   A0A2D0RSM9;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   05-JUN-2019, entry version 13.
DE   SubName: Full=unconventional myosin-IXa isoform X3 {ECO:0000313|RefSeq:XP_017333513.1};
GN   Name=myo9a {ECO:0000313|RefSeq:XP_017333513.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|Proteomes:UP000221080, ECO:0000313|RefSeq:XP_017333513.1};
RN   [1] {ECO:0000313|RefSeq:XP_017333513.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017333513.1};
RG   RefSeq;
RL   Submitted (NOV-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Myosin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00782}.
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DR   RefSeq; XP_017333513.1; XM_017478024.1.
DR   GeneID; 108270959; -.
DR   CTD; 4649; -.
DR   OrthoDB; 14881at2759; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003774; F:motor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00029; C1; 1.
DR   CDD; cd01385; MYSc_Myo9; 1.
DR   Gene3D; 1.10.555.10; -; 1.
DR   Gene3D; 3.40.850.10; -; 2.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR028558; MYO9A.
DR   InterPro; IPR001609; Myosin_head_motor_dom.
DR   InterPro; IPR036023; MYSc_Myo9.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR46184:SF3; PTHR46184:SF3; 1.
DR   Pfam; PF00612; IQ; 3.
DR   Pfam; PF00063; Myosin_head; 2.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   PRINTS; PR00193; MYOSINHEAVY.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00015; IQ; 4.
DR   SMART; SM00242; MYSc; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50096; IQ; 3.
DR   PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00782,
KW   ECO:0000256|SAAS:SAAS00875240}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000221080};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00253054};
KW   Motor protein {ECO:0000256|PROSITE-ProRule:PRU00782,
KW   ECO:0000256|SAAS:SAAS00874053};
KW   Myosin {ECO:0000256|PROSITE-ProRule:PRU00782,
KW   ECO:0000256|SAAS:SAAS01033784};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00782,
KW   ECO:0000256|SAAS:SAAS00874078};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221080};
KW   Zinc {ECO:0000256|SAAS:SAAS00253075}.
FT   DOMAIN       16    114       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   DOMAIN      148    993       Myosin motor. {ECO:0000259|PROSITE:
FT                                PS51456}.
FT   DOMAIN     1972   2021       Phorbol-ester/DAG-type.
FT                                {ECO:0000259|PROSITE:PS50081}.
FT   DOMAIN     2036   2224       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   NP_BIND     241    248       ATP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00782}.
FT   REGION      752    793       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
FT   REGION      875    897       Actin-binding. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00782}.
FT   REGION     1293   1339       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
FT   REGION     1355   1580       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
FT   REGION     1602   1764       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
FT   REGION     1780   1809       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
FT   REGION     2254   2292       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
FT   REGION     2330   2496       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
FT   COILED      993   1013       {ECO:0000256|SAM:Coils}.
FT   COILED     1209   1229       {ECO:0000256|SAM:Coils}.
FT   COILED     2299   2326       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    756    773       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
FT   COMPBIAS   1311   1325       Pro-rich. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
FT   COMPBIAS   1356   1373       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
FT   COMPBIAS   1412   1432       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
FT   COMPBIAS   1433   1508       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
FT   COMPBIAS   1509   1523       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
FT   COMPBIAS   1524   1548       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
FT   COMPBIAS   1626   1648       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
FT   COMPBIAS   1698   1715       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
FT   COMPBIAS   1724   1762       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
FT   COMPBIAS   2341   2366       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
FT   COMPBIAS   2395   2416       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
FT   COMPBIAS   2426   2453       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
FT   COMPBIAS   2454   2478       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RSM9}.
SQ   SEQUENCE   2496 AA;  286812 MW;  31EC0559E7E1F385 CRC64;
     MSIRDVGGRR RCFEDAELSL RVYPGAIAVG TIYCPILARK RTTAAEVIEQ VIARLRLDRT
     KCYVLAEVKE FGGEEWILNP SDCPAQRMML WPRAALENRS GSEDYRFLLR EKNVDGSIHY
     GNVAMWLQLT EERRRMVERG LLPPPQLQDH DDLCKLPDLS EKTLLENLRV RFRQEKIYTY
     VGSILVAINP FKFLPIYNPK YVKMYDNHQL GKLEPHIYAV ADVAYHAMLK RKRNQCIVIS
     GESGSGKTQS TNFLIHHLTA LSQKGFASGV EQIILGAGPV LEAFGNAKTA HNNNSSRFGK
     FIQVNYQESG TVRGAYVEKY LLEKSRLVYQ EHNERNYHVF YYLLAGASEE ERTAFHLLKP
     EEYHYLSQQD CFTVEGEDLK HDFERLQLAM EMVGFLPATR KQIFSLLSAI LHLGNIRYKK
     KTYRDDSIDI YNPEVLPIVS ELLEVKEEML FEALTTRKTV TVGEKLIVPY KLAEAGTVRD
     SMAKSLYSAL FDWIVFRINH ALLNNRELEE ATKILSIGVL DIFGFEDYEN NSFEQFCINF
     ANERLQHYFN QHIFKLEQEE YRAEGITWHN IDYIDNTGCI SLISKKPTAL LHLLDEECNF
     PQATNQTLLD KFKRQHEGNS YIEFPAVMEP AFIIRHYAGK VKYGVKDFRE KNTDHMRPDI
     VALLKSSRNA FIGGLIGIDP VATFRWAVLR AYCRAVVAFR EAGKRHTQKK SGHDAAAPCA
     VLKSVDSFSF LHHPVHQRSL EILQRCKEEK YSVSRRTPRT PLSDLQGSNN ERSNRDSRNG
     RSGRQSRLSS GSSITDEDGI FINSTSSKLL ERAHGILMRN KNYKMKPSLP KHLLDVKSLK
     YLSNLTLHDR ITKSLLHLHK KKKPPSISAQ FQASLNKLME TLGQSEPYFV KCIRSNAEKL
     PLRFNDTLVL RQLRYTGMLE TVRIRQSGYS IKYTFQEFVR HFHVMLPEDL QATQEDIRRY
     LCQVDLAPDG FQVGRTTVFM REVARQRLQD LLHQEVLRRI VNLQRRFRAV RERKSFLRMK
     HATRLIQDWW RSCQANQRDE QLKYDDNVRQ GAAICIQSAW RGFQERRRFL IWKEAVLVIQ
     RNWRLCHYRR YSQAAVTIQA AWRSYKAREQ YIHHRHIIVL FQAGCRGYLA RQRFKELRAQ
     KLKDSQLLNG QISPSPEEEK QKITGLDMRV WEDRSYEERE RSLQMQGEEA EAQLQDQVVI
     RERARLFDDS NLKTRAKRES RRMRELEQAK FSLELLKVRA TGGTSPSEDR RWSVEFASDG
     GISPQGTPDS QSSKGSFELV IIDDYAKDKV PCDEASFSVP PQHEALPNSP RITFPPKPLA
     PAVPSNSPKA EPDKLPALPK LENALPTFYV PPVESSSKFA KSSLDSSTSQ HQSPEKPVKD
     RSESTRRPVV VIISMQKENL LDGADLKPPE VRDSSAQTSE PPSPAQGEST TRSMLERLER
     LNEAKQERQK HQQQQNEKEM MEQIRQQKEI LEKQRKHFAQ YEREMFEKQR GEALQRIEQS
     RQERSGKVTD RSLPITQPEH DLTSSLHTQD KPDTPSKTRQ RPKDKQNVLD GWSPKLTSES
     QEGPAKEAQK MPPTSSVNVN MTERHGNVFF SPKDKVSISK LEKEFGGRGK SAAVQRETGT
     SEIKSSKPLK SREVARPGHK KARMARTRSD FLTRGSNPPG EGESDEEEYD ETPLSLGPPL
     PKQDSEGGTL DACHSDSEMP FTSREEQKRM MHKAMSSGDL GKSDSLRKTS HGDGRVRGKM
     KFWGKTKQGE KKSSRDRLLY PGESLDGDYP DTAFLMVEGE CLSPPHSPDS SSLPEFKENK
     EPSPKIKRRR SVKISSVTLE PAQWQNDALQ ILTCANDYRS MNEFLMKKIS DLDTEDSKKD
     TMVDVVFKKA LKEFRINIFN SYSTALAMDD GKSIRYKDLH ALFEQILEKT MRQEQRDWSE
     SPVRVWVNTF KVFLDEFMTE YKPLDSSMNK VIKPDRKKRR KKDTDIVEEH NGHIFKSTQY
     SIPTYCEFCS SLIWMMDRAC VCKLCRYACH RKCCLKTISK CSKKYDPELS SRQFGVDVSR
     LTHDDRSVPL VVEKLINYIE MHGLYTEGIY RKSGSTNKIK ELKQGLDTDV SSTNLDDYNI
     HVIASVFKQW LRDLPNPLMT FELYEEFLRA MGLQDRKEVV RGVYSVIDQL SRTHLNTLER
     LIFHLVRIVL QEETNRMSAN ALAIVFAPCI LRCPDTIDPL QSVQDISKTT ACVELIICEQ
     MNKYRARLKD ISTLEFAESK AKSRLTFIRR SMGKGRPRKL SYHSPSPPVS PHSPSAPEIT
     EESGDEDTVR DAEVTEQQHV AMQQEERVLT EELENLQKEK EELTYEMLSL EPRASDDETL
     ESEASIGTAD SSENLNVDSE GTISDFSEKG PTLAATRPKK PQGKSRRTLR RQPDSLDSVD
     SSSTVSSISS SNPQPLPPSR RFRPRSKLPP SSQNAAEQDS DERPIFSSRA TFSPEKSKLR
     DTKYSPQRPP EDQGHNRDPD LQAQQLVLYG ANEFMV
//
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