ID A0A2D0RST2_ICTPU Unreviewed; 629 AA.
AC A0A2D0RST2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Basic helix-loop-helix ARNT-like protein 1 {ECO:0000256|ARBA:ARBA00041169};
DE AltName: Full=Aryl hydrocarbon receptor nuclear translocator-like protein 1 {ECO:0000256|ARBA:ARBA00042144};
DE AltName: Full=Brain and muscle ARNT-like 1 {ECO:0000256|ARBA:ARBA00041751};
GN Name=bmal1b {ECO:0000313|RefSeq:XP_017333564.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017333564.1};
RN [1] {ECO:0000313|RefSeq:XP_017333564.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017333564.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus, PML body {ECO:0000256|ARBA:ARBA00004322}.
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DR RefSeq; XP_017333564.1; XM_017478075.3.
DR AlphaFoldDB; A0A2D0RST2; -.
DR GeneID; 108270977; -.
DR CTD; 352935; -.
DR OrthoDB; 2872674at2759; -.
DR Proteomes; UP000221080; Chromosome 10.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd11438; bHLH-PAS_ARNTL_PASD3; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR23042:SF52; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR23042; CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 78..131
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 149..214
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 353..402
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 33..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 629 AA; 69407 MW; C211457DB4BEA147 CRC64;
MNLCADLMAD QRMDISSTMN DFMSPSSTEL ISSSISTSSM DYTRKRKGSS TDYQDSMDMD
KDKQIGRDCI DQHGRIKNAR EAHSQIEKRR RDKMNSFIDE LASLVPTCNA MSRKLDKLTV
LRMAVQHMKT LRGAANPYTE ANYKPAFLSD DELKHLILKA ADGFLFVVGC DRGKILFVSE
SVYKILNYSQ NDLIGQSLFD YLHPKDIAKV KEQLSSSDTV PRERLIDAKT GLPVKTDITP
GPSRLCSGAR RSFFCRMKSN RPLIKMEDKD FTSPCSKKKA DRKSFCTIHS TGYLKSWPPM
QKGLDEDNEP DNEGCNLSCL VAIGRLHPHI VPQPMNGDIR VKPTEYVSRH AIDGKFVFVD
QRATAILAYL PQELLGTSFY EYFHQDDIGH LAECHRQVLQ MRDKISTNCY KFKVKDGSFI
TLRSRWFSFM NPWTKEVEYI VATNTVVSTG TRDGSDPSYL QLTASPRSMD SVLTADGSGK
RTLQTVPGIP GGTRAGAGKI GRMIAEEVME IQRIRGSSPS SCGSSPLNIT NSTPPPDTSS
PGGKKIQNGG TPDIPSAGMV SGQDSIGYPY SNNSLLSENS HISIGDIMDE PGSSSPSNDE
AAMAVIMSLL EADAGLGGPV DFSDLPWPL
//
