ID A0A2D0RTF7_ICTPU Unreviewed; 1898 AA.
AC A0A2D0RTF7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 2.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Cytoskeleton-associated protein 5 {ECO:0000313|RefSeq:XP_017333782.2};
GN Name=LOC108271062 {ECO:0000313|RefSeq:XP_017333782.2};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017333782.2};
RN [1] {ECO:0000313|RefSeq:XP_017333782.2}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017333782.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TOG/XMAP215 family.
CC {ECO:0000256|ARBA:ARBA00025722}.
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DR RefSeq; XP_017333782.2; XM_017478293.3.
DR STRING; 7998.ENSIPUP00000027365; -.
DR Ensembl; ENSIPUT00000028478; ENSIPUP00000027365; ENSIPUG00000018496.
DR KEGG; ipu:108271062; -.
DR OrthoDB; 5477703at2759; -.
DR Proteomes; UP000221080; Chromosome 10.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0061863; F:microtubule plus end polymerase; IEA:InterPro.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:InterPro.
DR GO; GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IEA:InterPro.
DR GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 5.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR045110; XMAP215.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR12609:SF0; CYTOSKELETON-ASSOCIATED PROTEIN 5; 1.
DR PANTHER; PTHR12609; MICROTUBULE ASSOCIATED PROTEIN XMAP215; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 5.
DR SMART; SM01349; TOG; 5.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
PE 3: Inferred from homology;
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..227
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 266..503
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 434..475
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 569..802
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 833..1068
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 1002..1039
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 1165..1403
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 505..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1066..1117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1394..1420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1861..1883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1081..1097
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1898 AA; 209275 MW; 983A930954E44256 CRC64;
MGDDSEWMKL PTDQKCEHKV WKARLSGYSE ALQHFQRISD EKSPEWGKYQ GLIKKFVTDS
NAVAQLKGLE AALAYVENAH VASRTVGEVV SGVVCKVFNQ PKARAKELGS DICLMYIEIE
KGDVIQEELL KGLDNKNPKI ALACVEVLRR AVSEFGAKII TLKPVVKVLP KLFESREKAI
RDEAKLLAVE VYRWIRDALR PPLQNINSIL LKELEDEWAK AAAPQQSRFL RSQQDLRVKF
EQQQQDGEEE GDDDVVEAAP AVDAYELLEA VEILSKLPKD FFEKIEAKKW QERREALEAL
EALTRNPKLE TGEYGDLVKA LNKVIGKDTN VMLVTLAAKC VAGLAVGLRK KFGTYVGHLV
PTILEKFKEK KAHVVQALQE ALDAAFLSTT LEKISEDVLA VMDNKNPSVR QQASLFLARS
FRHCTPTTLP KNLLKPFCVA LLKQVNDSAP EVRDAAFEAL GTALKVVGER AVNPFLADVD
KLKVDKIKEC AEKVELLGGK KAAGQVNEKN APKAPPAASA PNKPPAPAKK APTATAAKSS
APSKKGKNSA PKGTSAPAKA KKPDMTEAEL SPEVCEEKAA AVLPASCMQL MESANWKERV
AAMEEFIKAI ELMDDKEMPC QALVRMLAKK PGWKETNFQV MQLKLQVVSV VAQRGSFFSR
TSALAVLEAV VDKAGDVKCG VRAREALTAI AEACTLPWTA EQVVSVAFGQ KNPKNQAEAL
NWLCGAIKEF GFAGINVKAF INNVKTALAA TNPAVRTAAI SLLSVMYLYM GAPLRMFFED
EKAALLSQID AEFEKMKGQI PPPPIRGLSK TNSEEGQEEG DKEENDGGAD VVDLLPRTDI
SDKITSEMVS KIGDKNWKMR KEGLEEVTAV ISEAKFINPN IGELPVALKA RLTDSNKILV
QQTLSILQQM ATAMGPALKQ HVKGLGFPII TVLTDSKNAV RAAGLATLNA WVDQTGMKEW
LEGEDLAEEL KKDNPFLRQE LLGWLAEKLP TLRSVPLDFA LCVPHLYSCL EDRNADVRKK
AQDALPVFMM HLGYDKMNKA AAKLKPASKD QLVAMLEKAR SAVPAKPAAP SKAAPANPIS
VKPAAAPPVP DKTVPVSEPP PAESKKTKPA AAPKAKTVVK KLPGKVEEER DSPIFILVPN
GKEQRIKEEK SQKVLKWNFV TPREEFVDQL KNQMAACVNK WLMEDLFHTD FQKHIKAIRT
MMEHLEAESE ATVSCLDLIL KWFTLRFFDT NTSVLMKALE YLKLLFVTLS NQDYHLTEHE
ATSFIPYVIL KMGEPKDVVR KDVRSIFSLL RKVYPASRVF PFLMDGTKSK NSKQRAECLE
ELCCLVGLCG MSVFQQTAAK SLREIAVHIG DRDTAVRNAA LNTVVAAYNV CGEQVYKLVG
QLSEKDMSML EERIKRSAKK PSAPAAPVNK LQPEEKTSGL VTPSLLRRPN SEAVAPPKLS
EIRRQNPAVQ QQSPVVPRQF QLDPNFIVDL PEMVMPDLLV VETDGLSPLD VPEYKIPSVS
SSTEESVGSI SLVISQVASS DAQTSMQGLA KIVEILRKES EWKLMSGHVD EFIVAVLMQL
GLQASRRMGN EGTQHVEKLY TSVICSLSSL ALAGKLAQEA SLGVLKNLIQ ALLSLSLDPR
HQRSSGESQA LSRSIHILLS TLFQTADPTN TLSALLMLLQ EASNSTASTE FSEIVMKCHW
RMIKLLPEKI ESLYLDRVLL DIHKFMQAFP KELLKQKPYN MAHRTVKTLL HTMCRLVGPE
IIDHLSLIEN SSESEVEAHL RRAMKHSVAA PTPTSQNTQN MAKMKVQASA DAQKGMTAAA
SNSSTETLGA AHFQEKLRVL KQLYGPHGNI KANEDKSSLP VVSTKPCIPS SMDMLRSQLS
KLRESREQQG CENVKPPSPP ADIDEFRARL EKIKASMR
//
