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Database: UniProt
Entry: A0A2D0RTQ2_ICTPU
LinkDB: A0A2D0RTQ2_ICTPU
Original site: A0A2D0RTQ2_ICTPU 
ID   A0A2D0RTQ2_ICTPU        Unreviewed;      2182 AA.
AC   A0A2D0RTQ2;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   03-JUL-2019, entry version 13.
DE   SubName: Full=unconventional myosin-IXb isoform X4 {ECO:0000313|RefSeq:XP_017333340.1};
GN   Name=myo9b {ECO:0000313|RefSeq:XP_017333340.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|Proteomes:UP000221080, ECO:0000313|RefSeq:XP_017333340.1};
RN   [1] {ECO:0000313|RefSeq:XP_017333340.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017333340.1};
RG   RefSeq;
RL   Submitted (NOV-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Myosin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00782}.
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DR   RefSeq; XP_017333340.1; XM_017477851.1.
DR   GeneID; 108270880; -.
DR   CTD; 4650; -.
DR   OrthoDB; 14881at2759; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000146; F:microfilament motor activity; IEA:InterPro.
DR   GO; GO:0030048; P:actin filament-based movement; IEA:InterPro.
DR   GO; GO:0007266; P:Rho protein signal transduction; IEA:InterPro.
DR   CDD; cd00029; C1; 1.
DR   CDD; cd01385; MYSc_Myo9; 1.
DR   Gene3D; 1.10.555.10; -; 1.
DR   Gene3D; 3.40.850.10; -; 2.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR028557; MYO9B.
DR   InterPro; IPR001609; Myosin_head_motor_dom.
DR   InterPro; IPR036023; MYSc_Myo9.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR46184:SF2; PTHR46184:SF2; 2.
DR   Pfam; PF00612; IQ; 2.
DR   Pfam; PF00063; Myosin_head; 2.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   PRINTS; PR00193; MYOSINHEAVY.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00015; IQ; 3.
DR   SMART; SM00242; MYSc; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50096; IQ; 2.
DR   PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782,
KW   ECO:0000256|SAAS:SAAS01194079};
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00782,
KW   ECO:0000256|SAAS:SAAS00875240}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000221080};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00253054};
KW   Motor protein {ECO:0000256|PROSITE-ProRule:PRU00782,
KW   ECO:0000256|SAAS:SAAS00874053};
KW   Myosin {ECO:0000256|PROSITE-ProRule:PRU00782,
KW   ECO:0000256|SAAS:SAAS01033784};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00782,
KW   ECO:0000256|SAAS:SAAS00874078};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221080};
KW   Zinc {ECO:0000256|SAAS:SAAS00253075}.
FT   DOMAIN       15    113       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   DOMAIN      145    938       Myosin motor. {ECO:0000259|PROSITE:
FT                                PS51456}.
FT   DOMAIN     1676   1725       Phorbol-ester/DAG-type.
FT                                {ECO:0000259|PROSITE:PS50081}.
FT   DOMAIN     1744   1932       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   NP_BIND     238    245       ATP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00782}.
FT   REGION      821    843       Actin-binding. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00782}.
FT   REGION     1023   1158       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RTQ2}.
FT   REGION     1176   1387       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RTQ2}.
FT   REGION     1438   1470       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RTQ2}.
FT   REGION     1498   1526       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RTQ2}.
FT   REGION     1650   1672       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RTQ2}.
FT   REGION     2024   2049       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RTQ2}.
FT   REGION     2063   2094       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RTQ2}.
FT   COILED     2000   2020       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS   1023   1120       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RTQ2}.
FT   COMPBIAS   1121   1149       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RTQ2}.
FT   COMPBIAS   1185   1205       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RTQ2}.
FT   COMPBIAS   1212   1231       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RTQ2}.
FT   COMPBIAS   1246   1282       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RTQ2}.
FT   COMPBIAS   1290   1311       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RTQ2}.
FT   COMPBIAS   1330   1375       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RTQ2}.
FT   COMPBIAS   1451   1470       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RTQ2}.
FT   COMPBIAS   2029   2048       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RTQ2}.
FT   COMPBIAS   2064   2094       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A2D0RTQ2}.
SQ   SEQUENCE   2182 AA;  249561 MW;  4D89945A94B26576 CRC64;
     MSVTDGEGIA SQDGRAYVIQ IYPRLSLETA PCCIVRVRKE ATAATVIQDA AATLGLDVSK
     CYVLAEVKES GGEEWVLEAT DLPVHRVLLW PRKAQEEHAQ SEGFYFILQE RNRDGSICYA
     HLPTVCRDQD AQHLVARGFL PPCLEDVNDL CNLPILNEDT ILANLHSRFQ KKKIYTYAGS
     ILVAINPFKF LPIYNPKYVK MYENHQLGKL EPHIFAIADV SYYTMLRKRI NQCIVISGES
     GSGKTQSTNF LIHCLTALSQ KGYASGVERT ILGAGPVLEA FGNAKTAHNN NSSRFGKFIQ
     VNYLESGVVR GAVVEKYLLE KSRLVSREKN ERNYHVFYYL LVGASEEERK EYKLLQPENY
     SYLKQQNFTI EDADDLRHDF ERLQQAMEMV GFLPATKKQI FSVLSAILYL GNVTYSKKAT
     GRDEGLEVGP PEVLTNLSEL LKVKEELLVE ALTKRKTVTV NDKLILPYSH SEAITARDSM
     AKSLYSALFD WIVLRINHAL LNKKDMEESV PCLSIGVLDI FGFEDFETNS FEQFCINYAN
     EQLQYYFNQH IFTLEQEEYQ AEGITWHNID YTDNVGCIHL INKKPTGLLY LLDEESNFPH
     ATDITLLAKF KQQHERNHYF VPTPVMEPAF VIRHFAGKVK YQIKDFREKN TDHMRPDIVA
     LLRSSDRAYV RQLIGMDPVA MFRWGILRAA IRALAAFNEA GRRWAAKTSG VVRPVSRVPL
     GELQRSNTPI ERMYRQASML DFSFDLSEER PLEAFEDIFA SYESKKKNKN TKHKQLIPKN
     LLDSRSLKFI VGLHDRTTKS LLHLHKKKRP PSISAQFQTS LSKLLETLAK AEPFFIRCLR
     SNAEKKEMCF DEALILQQLR YTGMLETVRI RRSGYGAKYT FQEFLEQFRV LLPKDASSPE
     EISTLLKNLD LDPKTYQIGK TKVYLKELER QKLHDTLHKD VMHKIVFLQR WFRDKLQRRE
     FLQMRQAAIV LQRSWRDCRE RRGRAATLIQ AAWRGFKQRA KYQNRRASVT KIQALVRGQS
     ARRRYSSLKE EKRKREEEEA LRRKEEEEEA ARRVQEEAEV ARKTQEAEEA ARQEREAAEA
     TRRAQEEAKR LRDAEEAARR EKEAKEAAAK LSEENTKKES PEMQLNNQAV IKMDGQQENQ
     QTEAGPQHEA ELQDSQIKHV HNKSFVVLEK HNEDMRAVQE ATKGSNIALP ASDNPSITVT
     ALPKTSPKLS VEDDVKSSPT GSSTANTIHS DPGRSRGPPM GKLPASRSQE KRELRRQRGL
     EHSQRESVRA AAASKDESCK ELDQYTFISQ KVEKPKKETE DKEEKVKKEA VTSPIRPLTL
     PLEVPVSNDP KRAPRTKDVP SQEKSITQHE NMLKEPRPQQ DQRTKTLKTS RSLDDVSETS
     EVPTGFQGNV PYRKCPRRRH RLDFVRNCLN DKSAEMEDVE FWMYSHTIPV QPMPRVVEGP
     HGGRVGSVKR SPQDEGPHAH PHTPERSTGF FRKILKKRPH KEAQTPEDGD LTMAAALSEK
     ESTHSVPSSH THHSEPPSGR PSRNPTIKIS RATRVTEHWN ASLDREITNA NELRHLDEFL
     GNQVNDLRSR GKQLSATEHI FITATMQFRE NIKSMYSLSK PHIGYKGLMR GYQNKVISLA
     GEQQKCEVQL VVNLFQSVLD GFIRGEIKRE EAEPVKPPKG RKKRRKKDKN TESQLDHVFS
     NFQVNIMQSC DQCSSYIWVM EKAYVCSYCK LVCHKKCLSK IVTDCNTYCS KKSEEDSGCQ
     HFGVRVCRLV DDKVPVPMVL ELMLEHVEMN GLYTEGIYRK SGSANRMKEL RQLLEADPNS
     VCLEDYPIHT VTGLVKQWLR ELPEPLMTFN HYNDFLHAVE LPEKPEQVLA IYRVIEELPT
     AHYQTLERLI FHLVRVSREE KSNRMTPNSL AIVFAPCILR GPDSADPLLS MKDVAKTTTC
     VEMLINEQMR RYIERLEEIE QLEYAETLAK NQLKLKRSNT SWPLPLRFTS PYKGVAVKEK
     PSDLRVVPEN EPLDSDTEAE RNLMERIKSI KQEKEELVCR LPDMEQPGSD QENLDSEASA
     SSESLLDDRT TCLDMEGRMT IVLQTRKTKP SSSSSLPQLT SSGSQNFSCP SSPVATSYRN
     QLQRRYPIIP CTLRLPPGVF TLVQRRPRPG RRKDSIQSLF IGSGTELDAL SSASSSSSIP
     QNLLVSSRRF SDPDIAHIQD GV
//
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