ID A0A2D0RV49_ICTPU Unreviewed; 866 AA.
AC A0A2D0RV49;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Signal peptide, CUB and EGF-like domain-containing protein 2 isoform X6 {ECO:0000313|RefSeq:XP_017334377.1};
GN Name=scube2 {ECO:0000313|RefSeq:XP_017334377.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017334377.1};
RN [1] {ECO:0000313|RefSeq:XP_017334377.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017334377.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_017334377.1; XM_017478888.2.
DR AlphaFoldDB; A0A2D0RV49; -.
DR GeneID; 108271338; -.
DR CTD; 57758; -.
DR OrthoDB; 5477406at2759; -.
DR Proteomes; UP000221080; Chromosome 10.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF3; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 5.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 11.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..866
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013062078"
FT DOMAIN 31..71
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 114..150
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 318..358
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 359..397
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 398..438
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 678..790
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 363..373
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 866 AA; 96422 MW; 0A5D796FD2CC4017 CRC64;
MRSDSFALHF CVFLLLLKCE IKSAAILRDT DVDQCSEGSD ACHIDAICQN TPTFYKCTCK
SGFKGDGTHC EDIDECDSEF NGGCVHECNN IPGNYRCTCY DGFNLAHDGH NCLDVDECLF
NNGGCQHVCV NTMGSYECRC RHGFFLSDNQ HTCIHRSVEG LSCMNKEHGC EHICRETPKG
GVSCECRPGF ELAKNQRGCI LTCNHGNGGC HHVCEDTEHG PVCRCHARYM LQTDGRSCVE
RDDVTPSSSD HNATSLAEVD KRVKRRLLMD PSVLFTSYET CAVNNGGCDS MCKDTSTGVR
CSCPVGFTLQ PDGKSCEDID ECEFHNGGCD HLCRNTIGSF ECSCRKGFKL LTDERSCQDI
DECFFERTCD QTCVNSPGSF ECVCNKGYTL YGLAHCGDIN ECSVNNGGCG HVCENTMGGF
QCRCRAGYRL HWNKKDCVAE GCDLSCVKRR SEKRLKKTLR TLRKSINREQ FHLHFGSSEY
ELAKKPARAA DGPEPCGPGQ VLRDRKCVNC GVGTYHSSEQ GRCVPCPPGT YQDEEGQLVC
EVCPGPKGRA IPRTAGARSV AECGGQCSPG HFSHDGVVPC RPCPRGSYQP EVGRTSCLPC
GGNLVTRHEG AVSFQACETK VQCSPGHYYN TSTHRCIRCP LGTYQVEFGQ NFCVSCPGNT
TTDFDGSTSV TQCKNRHCGG VIGDYTGFIE SPNYPGDYPA NVECTWTISP PPKRRILIVV
PEIFLPMEDE CGDYLVMRKS SLPNSVTTYE TCQTYERPIA FTSRSKKLWI QFKSNEGNSR
KGFQVPYVTY DEDYQELIED IVRDGRLYAS ENHQEILKDK KLMKCLFDVL AHPQNFFNYT
AQESREMFPK SFIRFLRSKV LRFLRP
//
