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Database: UniProt
Entry: A0A2D0RVU9_ICTPU
LinkDB: A0A2D0RVU9_ICTPU
Original site: A0A2D0RVU9_ICTPU 
ID   A0A2D0RVU9_ICTPU        Unreviewed;       478 AA.
AC   A0A2D0RVU9;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   31-JUL-2019, entry version 9.
DE   SubName: Full=gamma-aminobutyric acid receptor subunit beta-3 isoform X3 {ECO:0000313|RefSeq:XP_017334628.1};
GN   Name=gabrb3 {ECO:0000313|RefSeq:XP_017334628.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|Proteomes:UP000221080, ECO:0000313|RefSeq:XP_017334628.1};
RN   [1] {ECO:0000313|RefSeq:XP_017334628.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017334628.1};
RG   RefSeq;
RL   Submitted (NOV-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
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DR   RefSeq; XP_017334628.1; XM_017479139.1.
DR   GeneID; 108271514; -.
DR   CTD; 2562; -.
DR   OrthoDB; 480926at2759; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR002289; GABAAb_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR01160; GABAARBETA.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   TIGRFAMs; TIGR00860; LIC; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|SAAS:SAAS00457684};
KW   Complete proteome {ECO:0000313|Proteomes:UP000221080};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00766067};
KW   Ion channel {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00081334};
KW   Ion transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457623};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_017334628.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221080};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457659}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32    478       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5013130310.
FT   TRANSMEM    249    271       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    278    295       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    315    338       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    459    476       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       45    248       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      256    473       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
FT   REGION      415    435       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   478 AA;  54512 MW;  9B41FB23C2C34809 CRC64;
     MFGMFGMFGI GKRKLFGIIS VPLLVALMCC AQSVNEPGNM SFVKETVDKL LKGYDIRLRP
     DFGGAPVSVG MTIDVASIDM VSEVNMDFTL TMYFQQYWRD KRLAYTGIPL NLTLDNRVAD
     QLWVPDTYFL NDKKSFVHGV TVKNRMIRLH PDGTVLYGLR ITTTAACMMD LRRYPLDEQN
     CTLEIESYGY TTDDIQFYWN GGDNAVSGVS QIELPQFSIV DYRLVSRNVV FSTGAYPRLS
     LSFKLKRNIG YFILQTYMPS ILITILSWVS FWINYDASAA RVALGITTVL TMTTINTHLR
     ETLPKIPYVK AIDMYLMGCF VFVFLALLEY AFVNYIFFGR GPQMQKKMAE KAEKANNDRT
     KYDGNKVDSQ GNILLTTLEI HNEVAGNEIT TSVSDARNST SVMLDNSGIQ YRKASGPRRH
     SVERNAQPKK ARLRRRSSQL KIKIPDLTDV NAIDRWSRII FPAVFSLFNL IYWLYYVN
//
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