ID A0A2D0RZB2_ICTPU Unreviewed; 1385 AA.
AC A0A2D0RZB2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=ca16b {ECO:0000313|RefSeq:XP_017335834.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017335834.1};
RN [1] {ECO:0000313|RefSeq:XP_017335834.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017335834.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 5 subfamily. {ECO:0000256|ARBA:ARBA00006246}.
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DR RefSeq; XP_017335834.1; XM_017480345.3.
DR Ensembl; ENSIPUT00000036891; ENSIPUP00000035495; ENSIPUG00000023782.
DR GeneID; 108272134; -.
DR KEGG; ipu:108272134; -.
DR CTD; 569183; -.
DR OrthoDB; 2903434at2759; -.
DR Proteomes; UP000221080; Chromosome 11.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd03122; alpha_CARP_receptor_like; 1.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR041887; Alpha_CARP_receptor-type.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF449; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE GAMMA; 1.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_017335834.1};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1385
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013243213"
FT TRANSMEM 712..737
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..315
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000259|PROSITE:PS51144"
FT DOMAIN 344..443
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 794..1061
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 981..1052
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1092..1350
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1267..1341
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 525..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..602
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1385 AA; 156594 MW; 72613E2FD65F3C7D CRC64;
MSVRNPHRSG LLCWGLSVLL IQSISSHPAA APPRMKHGKM SNQREKRAAG EPYWAYSGMH
GPWRWASMYP ECGEKNQSPV NIPDEHAWVS QECQELTLEG FEVKSSNKTS MKNTGKTVAI
LLKNDYFVRG AGLPGRFKAE KVEFHWGLSN GSAGSEHSIN GKRFPVEMQI FFYNSDDFDS
LNTAIKERRI IAAMAVFFQV GKKNNVAAEP IIAGLKRVVH HEKETNLAPF VLRDLLPSSL
GSYYRYAGSL TTPPCSKVVE WIILSRPVYL SYHQLEAFYS IFTTEQQDHV KSVEYLRNNF
RPTQDLHNRR VVKSAVKDAW FPDPMTDGHT SSTDTEPSRV CSSIPDNMKV RPLNRTAMVL
TWDRPSTIYH PPLVGFLVTY SWVKDDVTIE KMFTQSSEHH TRAVITHMSP DALYLFRVQA
LCQRDQRSDF SQTLLFKANT TRIFEGTRII KTGMPTVSSS SDMAPISSGS STWSSSGLPF
SFVSIATGMG PPSSGGQTTM ASLVTSTLLA GLGFSGGVIS SLPGSLWPTH SPSSGPAPTR
QPASPTSETT QNGNRPLPSE EGELTEELNK EEHKQEEDEE DDNEGERVEE KKKKEKNVTV
NEKKQEQTTL QEPADSVSPS GARGREGGLV NTEISTVSPI APEEKIYTVT LRPSRGDLSQ
TTWLQENYTT DMQLASSPTQ AIKLTNKEIH TERNSKLLVS REPASSVNRM EWIIPLMVVS
ALTLLCLIML LAVLVYWRKF FQTTHMYIED RNSPQVIHNE SLTGFLIADD LEALSVRQFI
KHVMELYSNN QQGFSQEFND IQHSVGDIEI TAEHSNHPDN KHKNRYINIV AYDHSRVKLQ
PLAGKDSKHT DYINANYVDG YNRPRAYIAA QGPLKSTFED FWRMIWEQSI SVIVMITNLV
EQGRRKCDQY WPSENTEEYG SIVVTLKSTK MLAWYTLRHF LIRNTRVTKS QKGRQNERLV
IQYHYTQWPD MGVPEYTLPV LTFISRSSAA RAPKSGPVLV HCSAGVGRTG TYIVIDSMLQ
QIKDKGMVNV LGFLKHIRTQ RNYLVQTEEQ YVFIHDALME AMLGKNTEVP ACKLHSYVNN
ILTLSPSGTT HIEKQFKLVM QCNIQKCFSA QKDCNKVKNR NSSVVPSEQA RVLLSPLRGM
KGTDYINASY ITGYYRSNEF IITQHPLPHT TMDFWRMIWD HNVQVIIMLP DNLSLTEDEF
VYWPSREQPM NCAAFTVTLI NTDTLCLCDE QQIIIHDFIL EATQDDYVLE VRHFQCPNWP
ELTGPVSNTF ELINIIKEEA MTRDGPTIVH DEFGGVSAGM LCALTTLYQQ LEIESAVDVY
QVAKMINLMR PGVFTDIEHY QYLYKAMLSL VGSTDSEIFC SYMGRHGRIL KTDKANPSES
MESLV
//
