ID   A0A2D0S028_ICTPU        Unreviewed;      1047 AA.
AC   A0A2D0S028;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=E3 ubiquitin-protein ligase PDZRN3-B isoform X2 {ECO:0000313|RefSeq:XP_017335791.1};
GN   Name=pdzrn3b {ECO:0000313|RefSeq:XP_017335791.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017335791.1};
RN   [1] {ECO:0000313|RefSeq:XP_017335791.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017335791.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_017335791.1; XM_017480302.3.
DR   AlphaFoldDB; A0A2D0S028; -.
DR   GeneID; 108272110; -.
DR   CTD; 100005518; -.
DR   OrthoDB; 2879659at2759; -.
DR   Proteomes; UP000221080; Chromosome 11.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00992; PDZ_signaling; 2.
DR   Gene3D; 2.30.42.10; -; 2.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   InterPro; IPR013010; Znf_SIAH.
DR   PANTHER; PTHR15545:SF5; E3 UBIQUITIN-PROTEIN LIGASE PDZRN3; 1.
DR   PANTHER; PTHR15545; PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4; 1.
DR   Pfam; PF00595; PDZ; 2.
DR   Pfam; PF13923; zf-C3HC4_2; 1.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF50156; PDZ domain-like; 2.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   SUPFAM; SSF49599; TRAF domain-like; 1.
DR   PROSITE; PS50106; PDZ; 2.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
DR   PROSITE; PS51081; ZF_SIAH; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00455}.
FT   DOMAIN          18..53
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   DOMAIN          77..135
FT                   /note="SIAH-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51081"
FT   DOMAIN          247..337
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          417..486
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   REGION          560..594
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          740..850
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          969..993
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        565..583
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        752..776
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        823..843
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1047 AA;  117653 MW;  98D7B0ACC0ACC55D CRC64;
     MGFELERFSG AVDPDLKCNL CHKVLEEPLT TPCGHVFCAA CVLPWVAQQR SCPAQCRRRV
     SAQELHHVPP LKSLVLKLDI RCEHHARGCR QVVKLQQLAE HAEACDFAPA RCRNDGCSEV
     LNLKDVHLHM RDACEYRPAG VCEQSCGLGL THRERYLDGH CCVRSLKAHN SALQAKVTTL
     EKECKKQAMR ASKREKSLLA QLSSVHNELQ MTALRYQKKF TEYSARIDSL TKSFAPPVKG
     GESKSVTVVL HRESGSLGFN IVGGRPCLDN EDGTSNDGIF VSKIVEHGPV DKEGGIQIHD
     RIMEVNGKDL SSATHEQAVE AFRTAKEPIM VQVLRRTPRP KPAGPEADAQ LMDISTQTDI
     TFQHIMALSK LPASTPPALD QYMLPEGHSP GHEYFDPNDY LETMPQDMER EELEYEEVDL
     YRTNIQDKLG LTVCYRTDDE DETGIYVSEI DPNSIAARDG RIREGDRIIQ INGIEVQNRE
     EAVSLLTSEE NRNVCLLVAR PEIQLDDGWM EDDRNDFLDD LHMDMLEQQH HQAMQFTASM
     LQQKPVEDGG LMDTGTLLSQ QHEKDSGVGR TDESTRNDES SEQENLCDDQ TSASTTLGSH
     RRLAYSQDTL GSSDLPFSNE SFISADYTDA DFLGDFPADE CEHFRELLEL KCQVRSGGGL
     GISWPSFGID GGQGFGGAGD DDVDKELELL NAELRNIELE CLSIVRAHRT QQLRDQPWML
     HNSGFRNYNT SVDARRHELA DISELPEKSD KDSSSAYNTG ESCRSTPLTL ELSPDNSLRR
     ASEELAEASA GGTVTGPNTR VLRPLLSPVQ EASGSSRSHT SSPKEPDAGH HSEAKERKSS
     RLSHPHSPYK HAHIPAHAQH YQSYMQLIQQ KSAVEYAQSQ MSLASMCRDP VSAEPKAEWK
     VKIRSDGTRY ITKRPARDRL LKERALRIRE ERSGGMTTDD DAASELKMGR YWSKEERKQH
     AVRAKEQRQR REFMKQSRTD WLKEQSGSGT DDKKEVNIIE LSHKKMMKKR NKKIFDNWMT
     IQELLTHGAR SPDGTRVYNS LLSVTTV
//