ID A0A2D0S191_ICTPU Unreviewed; 728 AA.
AC A0A2D0S191;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN Name=stat2 {ECO:0000313|RefSeq:XP_017335980.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017335980.1};
RN [1] {ECO:0000313|RefSeq:XP_017335980.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017335980.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR RefSeq; XP_017335980.1; XM_017480491.3.
DR AlphaFoldDB; A0A2D0S191; -.
DR GeneID; 108272207; -.
DR CTD; 6773; -.
DR OrthoDB; 7823at2759; -.
DR Proteomes; UP000221080; Chromosome 11.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0060429; P:epithelium development; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF41; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 597..700
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 111..167
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 728 AA; 84000 MW; 473F30D1F5360119 CRC64;
MAQWERLKQL DSVCLQRVDE LYHTDALPMA VREFLAHWIE EQDWVGATRD SSRAVVLFQI
LLENLDNQYS RFVQENNFLM HRNFRHFKQQ FQRYQEDPCN LAETINWFLI KEREILQAAE
LTQEVQMLQV QPSSMESETQ RNLEKSIRDF KSKVQAMEHS LRCLEEQQDE FDFKYQTHKM
DGTSWSLTPR LIDSSDPHTL KNEQELGDFR GTTDETEKCE QIKVLRVMLN RLNNGRKSFL
SETASLLNSA EHLLSVLLEE LVEWKRRQEV SCIGAPEDTN LEPLEKWFTA VGDRMFQLRK
FLQKLEELKD KLSYDEDPIK TQKPKLQDQV DALLTTLLKS AFVVETQPSM PQGRGPLVLR
TNVQFSVKTR FLFKVPELNH AMKVGVSINK DVPSVKGYRR FNVLGTSSKA LNMSESMSGG
MVADFRHLTL KEQKVGGGGK GNNDLSLSVT EELHTIHFET QFNLHGLSVS LETCSLPVVV
ISNSSQQQSA WASVLWFIML STDPKNLVFF ASSPVATWSQ LGQMLSWQFQ SCAKRGLDAD
QLDTLALKLF GKQDNYENCK ISWTRFSKEN IPGQNFTLWV WLDGILNLVK VYLANMWEDG
SIMGFVSKGT EKALLKKKQS GTFLLRFSES IRDGGITFSW VEYCNKGMPN VRTVQPFTSV
DLKQIPFPEI LRNFQIMEAD NAPVYPLQFL YPNTPKDQAF GKYYNEKTGE ESPYIKYIRT
KLVFVSKE
//
